Zobrazeno 1 - 10
of 42
pro vyhledávání: '"R R, Tice"'
Publikováno v:
Environmental Health Perspectives
The Genetic Activity Profile (GAP) database was used to identify and compare agents showing genotoxic activity in humans. The database revealed several substances for which both human and rodent cytogenetic data existed. Based on the ratio of the low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276b5f6d560ce8f73a725881a24cb092
http://europepmc.org/articles/PMC1469649
http://europepmc.org/articles/PMC1469649
Publikováno v:
Environmental and Molecular Mutagenesis. 21:160-179
Forty-nine chemicals were tested in a mouse bone marrow micronucleus test that employed three daily exposures by intraperitoneal injection. Bone marrow samples were obtained 24 hr following the final exposure. Twenty-five rodent carcinogens and 24 no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef82f0abc3864ffdce2c0512d8dfeef
https://doi.org/10.1002/em.2850210210
https://doi.org/10.1002/em.2850210210
Autor:
A, Hartmann, E, Agurell, C, Beevers, S, Brendler-Schwaab, B, Burlinson, P, Clay, A, Collins, A, Smith, G, Speit, V, Thybaud, R R, Tice
Publikováno v:
Mutagenesis. 18(1)
The in vivo alkaline single cell gel electrophoresis assay, hereafter the Comet assay, can be used to investigate the genotoxicity of industrial chemicals, biocides, agrochemicals and pharmaceuticals. The major advantages of this assay include the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79d7e34be5c42029f915bc7e2581a242
https://pubmed.ncbi.nlm.nih.gov/12473734
https://pubmed.ncbi.nlm.nih.gov/12473734
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 34(3)
To evaluate the reliability of the murine local lymph node assay (LLNA), a test for allergic contact dermatitis activity, the inter- and intralaboratory consistency statistics (h and k, respectively) were calculated for validation studies testing mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2ca725f4d1a57cfd89074c2ca2c679c
https://pubmed.ncbi.nlm.nih.gov/11754531
https://pubmed.ncbi.nlm.nih.gov/11754531
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 34(3)
The validation status of the murine local lymph node assay (LLNA), a method for assessing the allergic contact dermatitis potential of chemicals, was evaluated by an independent peer review panel (Panel) convened by the Interagency Coordinating Commi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::afad5ede73cb8aeee5510761fdf091ed
https://pubmed.ncbi.nlm.nih.gov/11754530
https://pubmed.ncbi.nlm.nih.gov/11754530
Publikováno v:
Environmental and Molecular Mutagenesis. 17:1-3
Induction of sister chromatid exchangers (SCE) has been used as evidence of genotoxicity of test compounds administered both in vitro and in vivo. The authors have previously reported their efforts to measure SCE frequencies in colonic tissue in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4928848ad1ebe263ec7e39eed5c1903a
https://doi.org/10.1002/em.2850170102
https://doi.org/10.1002/em.2850170102
Publikováno v:
Environmental and molecular mutagenesis. 33(1)
The induction of micronucleated erythrocytes by diisopropylcarbodiimide (DIC) and dicyclohexylcarbodiimide (DCC) was investigated as part of a U.S. National Toxicology Program (NTP) evaluation of the subchronic toxicity of these chemicals. Analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b779fd7b9d24043377f1df100aab756e
https://pubmed.ncbi.nlm.nih.gov/10037325
https://pubmed.ncbi.nlm.nih.gov/10037325
Publikováno v:
Environmental and molecular mutagenesis. 31(2)
Phenolphthalein, a common ingredient in nonprescription laxatives and a multisex, multispecies rodent carcinogen, was evaluated under chronic exposure conditions for genotoxicity in transgenic female mice heterozygous for the p53 gene (heterozygous T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3137285ba1baa928a049dc5c0ccfb07
https://pubmed.ncbi.nlm.nih.gov/9544189
https://pubmed.ncbi.nlm.nih.gov/9544189
Publikováno v:
Environmental and molecular mutagenesis. 29(3)
Acrylates may be polymerized to stable surface coatings (paints, lacquers, inks, etc.) by alkylation via the Michaelis-type addition reaction. Thus, acrylates have an inherent potential as electrophiles to be genotoxic, limited in their biological ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f03f33488ac02efead921111978112f6
https://pubmed.ncbi.nlm.nih.gov/9142166
https://pubmed.ncbi.nlm.nih.gov/9142166
Publikováno v:
Environmental and molecular mutagenesis. 27(1)
Chlorination is a widely used method for disinfection of drinking water supplies. Reaction of chlorine with naturally present organic compounds can result in toxic by-products. One major disinfection by-product from the chlorination of drinking water
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5265676795ca6ccb2cf828493319a354
https://pubmed.ncbi.nlm.nih.gov/8625942
https://pubmed.ncbi.nlm.nih.gov/8625942