Zobrazeno 1 - 10
of 92
pro vyhledávání: '"R R, Osborn"'
Autor:
D C, Underwood, R R, Osborn, C J, Kotzer, J L, Adams, J C, Lee, E F, Webb, D C, Carpenter, S, Bochnowicz, H C, Thomas, D W, Hay, D E, Griswold
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(1)
The anti-inflammatory/antiallergic activity of a novel second-generation p38 mitogen-activated protein kinase inhibitor, SB 239063[trans-1-(4-hydroxycyclohexyl) -4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole], was investigated in vivo and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ad7ba37cf0e2b9aba0d71fd1b23c0b7
https://pubmed.ncbi.nlm.nih.gov/10734180
https://pubmed.ncbi.nlm.nih.gov/10734180
Autor:
D C, Underwood, S, Bochnowicz, R R, Osborn, C J, Kotzer, M A, Luttmann, D W, Hay, P D, Gorycki, S B, Christensen, T J, Torphy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(3)
We evaluated the airway activity of the novel phosphodiesterase type 4 inhibitor SB 207499 [Ariflo; c-4-cyano-4-(3-cyclopentyloxy-4-methoxyp henyl-r-1-cyclohexane carboxylic acid)], in the guinea pig. Ovalbumin (OA)-induced contractions of guinea pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a0a6446448f630e896fdf7b5a7054cf
https://pubmed.ncbi.nlm.nih.gov/9864284
https://pubmed.ncbi.nlm.nih.gov/9864284
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(3)
This study investigated the effects of the nonpeptide endothelin (ET) receptor antagonist, SB 217242, against ET-1-induced pulmonary pressor responses and in a model of hypoxia-induced pulmonary hypertension in the guinea pig. In guinea pig isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c82a62dc15baaad166bf457e82784ca
https://pubmed.ncbi.nlm.nih.gov/9399985
https://pubmed.ncbi.nlm.nih.gov/9399985
Publikováno v:
Laboratory animals. 31(4)
Prolonged exposure to hypoxia elicits a variety of time-related morphologic and physiologic changes in the pulmonary vasculature of mammals, including humans. The study of hypoxia-induced changes in rodents generally requires a prolonged exposure to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57715ee55418bd337998f450d8b4b7ae
https://pubmed.ncbi.nlm.nih.gov/9350706
https://pubmed.ncbi.nlm.nih.gov/9350706
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(1)
Selective inhibitors of the low-Km cAMP-specific phosphodiesterase (PDE4) inhibit inflammatory cell function and relax airway smooth muscle. Thus PDE4 inhibitors may be useful in the therapy of asthma. The present study was conducted to determine whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0aa83d38ce8aa4a581206ed57a71f96f
https://pubmed.ncbi.nlm.nih.gov/8996198
https://pubmed.ncbi.nlm.nih.gov/8996198
Publikováno v:
American journal of respiratory and critical care medicine. 154(4 Pt 1)
Aerosolized cysteinyl leukotrienes (CysLTs) elicit migration of eosinophils into guinea pig lungs and the airways of patients with asthma. The present studies were designed to analyze the concentration-response relationship, time course, and pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d03ee929ccf6b07d0593febbe71796f
https://pubmed.ncbi.nlm.nih.gov/8887574
https://pubmed.ncbi.nlm.nih.gov/8887574
Autor:
Lavonne D. Meunier, R. R. Osborn, David C. Underwood, Linda B. Novak, Jane K. Matthews, Steven Bochnowicz
Publikováno v:
International archives of allergy and immunology. 109(3)
The aim of the present study was to analyze the increased airway reactivity to antigen induced by beta-adrenoceptor blockade, adrenalectomy or medullectomy and to assess the contribution of circulating catecholamines to the increased reactivity. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe72f97d4779d964796be42f2dc31d4
https://pubmed.ncbi.nlm.nih.gov/8620099
https://pubmed.ncbi.nlm.nih.gov/8620099
Autor:
R R, Osborn
Publikováno v:
Radiology management. 18(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b11c47b579183a3ec8d7ebe52300e4f
https://pubmed.ncbi.nlm.nih.gov/10161323
https://pubmed.ncbi.nlm.nih.gov/10161323
Autor:
D C, Underwood, C J, Kotzer, S, Bochnowicz, R R, Osborn, M A, Luttmann, D W, Hay, T J, Torphy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(1)
Selective inhibition of phosphodiesterase (PDE) isozymes has been shown to inhibit inflammatory cell function and relax airway smooth muscle and, thus, may be useful in the therapy of asthma. In guinea pigs sensitized to ovalbumin (OA), the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6438fb69177e748cc1af68c7066d58cc
https://pubmed.ncbi.nlm.nih.gov/8035322
https://pubmed.ncbi.nlm.nih.gov/8035322
Autor:
D C, Underwood, R R, Osborn, L B, Novak, J K, Matthews, S J, Newsholme, B J, Undem, J M, Hand, T J, Torphy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(1)
Selective inhibition of the low Km cyclic AMP-specific phosphodiesterase has been shown to inhibit inflammatory cell function and relax airway smooth muscle. These studies were conducted to characterize the bronchodilator and anti-inflammatory activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc7caa2fa596bbcfb84878e0d9cc9a52
https://pubmed.ncbi.nlm.nih.gov/8392555
https://pubmed.ncbi.nlm.nih.gov/8392555