Zobrazeno 1 - 10 of 53 pro vyhledávání: '"R R, Luther"'
1
Fenoldopam, a dopamine agonist, for hypertensive emergency: a multicenter randomized trial. Fenoldopam Study Group
Autor: J A, Tumlin, L M, Dunbar, S, Oparil, V, Buckalew, C V, Ram, V, Mathur, D, Ellis, D, McGuire, J, Fellmann, R R, Luther
Publikováno v: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 7(6)
Despite successful therapies for chronic hypertension, hospital admissions for hypertensive emergency more than tripled between 1983 and 1992.To examine the safety and efficacy of fenoldopam, the first antihypertensive with selective and specific act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a669c40f24a2f866aaf0486b17061018
https://pubmed.ncbi.nlm.nih.gov/10905644
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2
Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of enalkiren (Abbott-64662, a new renin inhibitor). I: Single dose study
Autor: S K, Gupta, G R, Granneman, R S, Boger, N K, Hollenberg, R R, Luther
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 20(6)
This study describes the relationship between the measured effects (angiotensin I and renal plasma flow) and plasma drug levels using a combined pharmacokinetic-pharmacodynamic model after 90 min iv infusion of enalkiren in 15 healthy, salt-depleted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d1c58f64ddb5d5bc06ef60f53746eae
https://pubmed.ncbi.nlm.nih.gov/1362933
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3
Prolonged duration of blood pressure response to enalkiren, the novel dipeptide renin inhibitor, in essential hypertension
Autor: D Moyse, A Cohen, J H Cavanaugh, H D Kleinert, R R Luther, J Lamm, R S Boger, H N Glassman, P J Schmitz
Publikováno v: Hypertension (Dallas, Tex. : 1979). 15(6 Pt 2)
The effects of sustained renin inhibition by repeated administration of enalkiren (A-64662), the novel dipeptide renin inhibitor, were evaluated in a randomized, double-blind, placebo-controlled, parallel-group study of 32 inpatients (eight per group
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb40b5955bf0b9d6850dce51bc6846e
https://pubmed.ncbi.nlm.nih.gov/2190927
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4
Effects of terazosin on serum lipid levels in hypertensive blacks
Autor: R R, Luther, M J, Klepper, C J, Maurath, H N, Glassman, R, Achari, A R, Laddu
Publikováno v: Journal of human hypertension. 4(2)
The effects of terazosin, a new, selective, alpha 1-adrenoceptor antagonist, on the serum lipid levels were examined in 103 black patients with uncomplicated, mild to moderate essential hypertension in six randomized, double-blind, placebo-controlled
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68cfedccd0df35aa1b40ce0544bdf285
https://pubmed.ncbi.nlm.nih.gov/1971028
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6
The management of severe chronic pain with a focus on new treatment modalities
Autor: D McGuire, M DuBois, R R Luther
Publikováno v: Drugs of Today. 34:481
Pain is the most common reason for consultation with a physician, but because pain is not objectively measurable, it is often neglected or underestimated. Chronic, severe pain is a major complication of cancer and HIV-1 infection. Current therapy typ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd0bd6fca72015ce32106dfea7730d1
https://doi.org/10.1358/dot.1998.34.5.485246
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8
Pharmacologic Effects of A-49816, a New High-Ceiling Diuretic
Autor: R R, Luther, G L, Ringham, F J, Steinberg, K J, Patterson, D C, Jordan, D E, Rollins, K G, Tolman
Publikováno v: The Journal of Clinical Pharmacology. 27:794-801
The pharmacologic effects of A-49816, a high-ceiling, loop diuretic, were evaluated in a single-blind, placebo-controlled, randomized trial. Eighteen (18) normal volunteers aged 19 to 40 years were divided into three groups. The subjects in each grou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58930e61afd180b526039adf0700d1d3
https://doi.org/10.1002/j.1552-4604.1987.tb02999.x
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9
Effects of the renin inhibitor A-64662 in monkeys and rats with varying baseline plasma renin activity
Autor: J R Luly, D Martin, H. D. Kleinert, T J Perun, J J Plattner, M. A. Chekal, J. R. C. Kadam, R R Luther
Publikováno v: Hypertension. 11:613-619
The efficacy of the potent, primate selective renin inhibitor A-64662 was studied in monkeys and rats with varying baseline plasma renin activity (PRA) to elucidate the relationship between PRA and the hypotensive response induced by this compound. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a1aab9fe06635e48d79704c72d37be
https://doi.org/10.1161/01.hyp.11.6.613
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10
Effect of age on the pharmacokinetics of orally and intravenously administered terazosin
Autor: L T, Sennello, R C, Sonders, H N, Glassman, D C, Jordan, R R, Luther, K G, Tolman
Publikováno v: Clinical therapeutics. 10(5)
Terazosin, a new long-acting selective alpha 1-receptor antagonist, was studied in a crossover trial to assess the effect of age on oral and intravenous pharmacokinetics. Thirty healthy male and female volunteers between the ages of 23 and 75 years r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d7835c4232e470e30d42d679b10533d
https://pubmed.ncbi.nlm.nih.gov/2908805
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