Výsledky vyhledávání - "R R, Hantgan"

Autor: C D Webb, R R Hantgan, P D Byeff, J Owen

Publikováno v: Blood Coagulation & Fibrinolysis. 5:233-238

Routine laboratory screening identified an abnormal fibrinogen in an asymptomatic patient from New Britain, Connecticut. This paper reports the characterization of the abnormal fibrinogen. Clinical clotting studies showed marked prolongation of both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef1d2ff31b088b7f2a6137a511016c13
https://doi.org/10.1097/00001721-199404000-00012

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AlphaIIb's cytoplasmic domain is not required for ligand-induced clustering of integrin alphaIIbbeta3

Autor: R R, Hantgan, M, Stahle, V, Del Gaizo, M, Adams, T, Lasher, W G, Jerome, M, McKenzie, D S, Lyles

Publikováno v: Biochimica et biophysica acta. 1540(1)

The platelet integrin alphaIIbbeta3 exhibits bidirectional signaling, in that intracellular messengers enable adhesive macromolecules to bind to its ectodomain, while ligation promotes the association of cytoskeletal proteins with its cytoplasmic dom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a406e5a8c44b11379a873ccec1026e1
https://pubmed.ncbi.nlm.nih.gov/11476897

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Fibrinogen Longmont. A heterozygous abnormal fibrinogen with B beta Arg-166 to Cys substitution associated with defective fibrin polymerization

Autor: K C, Lounes, J B, Lefkowitz, A I, Coates, R R, Hantgan, A, Henschen-Edman, S T, Lord

Publikováno v: Annals of the New York Academy of Sciences. 936

B beta Arg166 to Cys substitution was identified in an abnormal fibrinogen named fibrinogen Longmont. The proband, a young woman, and her mother were heterozygous; both experienced episodes of severe hemorrhage at childbirth. The neo-Cys residues wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a73e0a87e921a1351fa97590c5a97895
https://pubmed.ncbi.nlm.nih.gov/11460470

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Effect of the apolipoprotein A-IV Q360H polymorphism on postprandial plasma triglyceride clearance

Autor: K J, Hockey, R A, Anderson, V R, Cook, R R, Hantgan, R B, Weinberg

Publikováno v: Journal of lipid research. 42(2)

Apolipoprotein (apo)A-IV is synthesized in the small intestine during fat absorption and is incorporated onto the surface of nascent chylomicrons. In circulation, apoA-IV is displaced from the chylomicron surface by high density lipoprotein-associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1df2ae368e5d0caed800f82924ae03fc
https://pubmed.ncbi.nlm.nih.gov/11181750

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Recombinant fibrinogen Vlissingen/Frankfurt IV. The deletion of residues 319 and 320 from the gamma chain of firbinogen alters calcium binding, fibrin polymerization, cross-linking, and platelet aggregation

Autor: K A, Hogan, O V, Gorkun, K C, Lounes, A I, Coates, J W, Weisel, R R, Hantgan, S T, Lord

Publikováno v: The Journal of biological chemistry. 275(23)

We synthesized a variant, recombinant fibrinogen modeled after the heterozygous dysfibrinogen Vlissingen/Frankfurt IV, a deletion of two residues, gammaAsn-319 and gammaAsp-320, located within the high affinity calcium-binding pocket. Turbidity studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6baa23e2029a956fdc887c9b1b61857f
https://pubmed.ncbi.nlm.nih.gov/10748039

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No effect of clot age or thrombolysis on argatroban's inhibition of thrombin

Autor: R R, Hantgan, W G, Jerome, M J, Hursting

Publikováno v: Blood. 92(6)

The purpose of this study was to establish the effects of clot age and thrombolysis, with either streptokinase or tissue-type plasminogen activator (tPA), on argatroban's ability to inhibit thrombin. The antithrombotic activity of argatroban has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7ed6a3e5a448b3eb54b80671d18b93e
https://pubmed.ncbi.nlm.nih.gov/9731064

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Platelets and endothelial cells act in concert to delay thrombolysis--evidence from an in vitro model of the human occlusive thrombus

Autor: R R, Hantgan, W G, Jerome, S, Handt

Publikováno v: Thrombosis and haemostasis. 79(3)

The molecular and cellular mechanisms that over a period of hours render a human thrombus progressively resistant to fibrinolysis have been probed with a novel in vitro model. The kinetics of clot formation and fibrinolysis were monitored by laser li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da949fb64e382ad1e0d93e1e0e8b32a4
https://pubmed.ncbi.nlm.nih.gov/9531049

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Plasminogen activator inhibitor-1 secretion of endothelial cells increases fibrinolytic resistance of an in vitro fibrin clot: evidence for a key role of endothelial cells in thrombolytic resistance

Autor: S, Handt, W G, Jerome, L, Tietze, R R, Hantgan

Publikováno v: Blood. 87(10)

Time-dependent thrombolytic resistance is a critical problem in thrombolytic therapy for acute myocardial infarction. Platelets have been regarded as the main source of plasminogen activator inhibitor-1 (PAI-1) found in occlusive platelet-rich clots.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3904d9a44d9a606f6cbb5051b2c58b9a
https://pubmed.ncbi.nlm.nih.gov/8639779

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Endothelial Cells Organize Fibrin Clots into Structures that are More Resistant to Lysis

Autor: W. Gray Jerome, Stefan Handt, P G Yancey, R R Hantgan

Publikováno v: Microscopy and Microanalysis. 10:1402-1403

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91c61c7ac7a79c06adf3f8892d5c69a6
https://doi.org/10.1017/s1431927604882904

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On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood

Autor: S C, Endenburg, R R, Hantgan, L, Lindeboom-Blokzijl, H, Lankhof, W G, Jerome, J C, Lewis, J J, Sixma, P G, de Groot

Publikováno v: Blood. 86(11)

Platelet adhesion to fibrin at high shear rates depends on both the glycoprotein (GP) IIb:IIIa complex and a secondary interaction between GPIb and von Willebrand factor (vWF). This alternative link between platelets and vWF in promoting platelet adh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e6eef8d33462aee47b87f978890543d7
https://pubmed.ncbi.nlm.nih.gov/7492773

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