Zobrazeno 1 - 10 of 128 pro vyhledávání: '"R R, French"'
1
Immunological Methods to Study Monoclonal Antibody Activity in Chronic Lymphocytic Leukaemia
Autor: M J, Carter, L N, Dahal, K L S, Cleary, M J E, Marshall, R R, French, S A, Beers, M S, Cragg
Publikováno v: Methods in molecular biology (Clifton, N.J.). 1881
Over recent decades it has become increasingly apparent that malignant cells, including chronic lymphocytic leukemia (CLL) cells, do not exist in isolation. Rather they coalesce with numerous "normal" cells of the body and, in the case of CLL, inhabi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7a690adebaddbae662c1c5b9ee5f9e6
https://pubmed.ncbi.nlm.nih.gov/30350206
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2
The application of monoclonal antibodies in the treatment of lymphoma
Autor: M J, Glennie, J, Honeychurch, R R, French, A L, Tutt
Publikováno v: Methods in molecular medicine. 40
Monoclonal antibodies (mAbs) appear to offer many benefits for the treatment of cancer and in particular lymphoma (1). They are natural products that can be made with precise specificity and in almost unlimited amounts. In addition, mAbs can be selec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0eddbc81f9ea57a61fe3ebc357ee5566
https://pubmed.ncbi.nlm.nih.gov/21337085
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3
How to make bispecific antibodies
Autor: R R, French
Publikováno v: Methods in molecular medicine. 40
This protocol describes the production of bispecific F(ab')2 antibody derivatives (BsAbs) by the linking of two Fab' fragments via their hinge region SH groups using the bifunctional crosslinker o-phenylenedimaleimide (o-PDM) as described by Glennie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3599f08649db56d9af9fcd5f3e172ea7
https://pubmed.ncbi.nlm.nih.gov/21337104
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8
Delivery of saporin to human B-cell lymphoma using bispecific antibody: targeting via CD22 but not CD19, CD37, or immunoglobulin results in efficient killing
Autor: M A, Bonardi, R R, French, P, Amlot, G, Gromo, D, Modena, M J, Glennie
Publikováno v: Cancer research. 53(13)
A panel of bispecific F(ab')2 antibodies (BsAb) have been constructed for delivering the ribosome-inactivating protein saporin to human B cell lymphoma. Each derivative was prepared with specificity for saporin and CD19, CD22, CD37, or immunoglobulin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f63de7527cf8dd247149714e7bceb6d
https://pubmed.ncbi.nlm.nih.gov/7686448
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9
Initial experience in treating human lymphoma with a combination of bispecific antibody and saporin
Autor: M A, Bonardi, A, Bell, R R, French, G, Gromo, T, Hamblin, D, Modena, A L, Tutt, M J, Glennie
Publikováno v: International journal of cancer. Supplement = Journal international du cancer. Supplement. 7
Results are presented showing the use of bispecific F(ab')2 antibodies (bsAbs) in the delivery of saporin for the treatment of 2 human B-cell malignancies. BsAbs delivering saporin through CD22, but not through CD19, were effective at inhibiting the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5dea9d3842564725f0ee024592c5422
https://pubmed.ncbi.nlm.nih.gov/1428411
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10
Cooperative mixtures of bispecific F(ab')2 antibodies for delivering saporin to lymphoma in vitro and in vivo
Autor: R R, French, A E, Courtenay, S, Ingamells, G T, Stevenson, M J, Glennie
Publikováno v: Cancer research. 51(9)
We report that selected combinations of two or more monoclonal bispecific F(ab')2 antibodies (BsAbs) far outperform single derivatives in the delivery of the ribosome-inactivating protein, saporin, to guinea pig L2C leukemic cells. Throughout the wor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::593ccb89ad6fd1bc9641400954b161ce
https://pubmed.ncbi.nlm.nih.gov/2015599
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