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Publikováno v:
Journal of Biological Chemistry. 275:27013-27020
ATF6 is a member of the basic-leucine zipper family of transcription factors. It contains a transmembrane domain and is located in membranes of the endoplasmic reticulum. ATF6 has been implicated in the endoplasmic reticulum (ER) stress response path
Autor:
Y, Wang, M, Falasca, J, Schlessinger, S, Malstrom, P, Tsichlis, J, Settleman, W, Hu, B, Lim, R, Prywes
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 9(7)
Many growth factors rapidly induce transcription of the c-fos proto-oncogene. We have investigated the pathways for induction of the c-fos promoter by serum and epidermal growth factor (EGF) in HeLa cells. Induction of the serum response element (SRE
Autor:
D J, Thuerauf, N D, Arnold, D, Zechner, D S, Hanford, K M, DeMartin, P M, McDonough, R, Prywes, C C, Glembotski
Publikováno v:
The Journal of biological chemistry. 273(32)
In various cell types certain stresses can stimulate p38 mitogen-activated protein kinase (p38 MAPK), leading to the transcriptional activation of genes that contribute to appropriate compensatory responses. In this report the mechanism of p38-activa
Publikováno v:
The Journal of biological chemistry. 272(33)
The c-Jun amino-terminal kinases (JNKs) are a subfamily of mitogen-activated protein kinases that phosphorylate c-Jun and ATF2, and it has been postulated that phosphorylated c-Jun enhances its own expression through AP-1 sites on the c-jun promoter.
Autor:
R, Prywes
Publikováno v:
Methods (San Diego, Calif.). 12(3)
Publikováno v:
The New biologist. 3(5)
Serum response factor (SRF), a transcription factor that binds to the serum response element (SRE) of the c-fos proto-oncogene, activates transcription of an SRE-containing reporter plasmid in vitro. We describe here preincubation experiments which i
Publikováno v:
Genesdevelopment. 4(6)
Serum response factor (SRF) is a mammalian transcription factor that binds to the serum response element in the enhancer of the c-fos proto-oncogene and thus may mediate serum-induction of c-fos transcription. We report here that the DNA binding acti
Publikováno v:
Molecular and Cellular Biology. 8:2302-2308
The tumor promoter phorbol ester (TPA) modulates the binding affinity and the mitogenic capacity of the epidermal growth factor (EGF) receptor. Moreover, TPA-induced kinase C phosphorylation occurs mainly on Thr-654 of the EGF receptor, suggesting th
Publikováno v:
The EMBO Journal. 5:2179-2190
Binding of epidermal growth factor (EGF) to its receptor results in a cascade of events that culminate in cell division. The receptor is present on the cell surface in two forms of high and low affinity binding for EGF. EGF binding activates the rece