Zobrazeno 1 - 10
of 1 013
pro vyhledávání: '"R Pollard"'
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 6, Iss , Pp 100065- (2022)
Epilepsy affects over 50 million people worldwide and increases the risk of death. An intrinsic state of central inflammation, mainly driven by TNFα/NFκB signaling, may contribute to the refractory nature of some epilepsies. We have therefore hypot
Externí odkaz:
https://doaj.org/article/498ae7e6baf94c7c804821f3a8df5a15
Autor:
Alyssa C. Pollard, Jorge de la Cerda, F. William Schuler, Tyler R. Pollard, Aikaterini Kotrotsou, Federica Pisaneschi, Mark D. Pagel
Publikováno v:
Biosensors, Vol 12, Iss 2, p 134 (2022)
Acidosis is a useful biomarker for tumor diagnoses and for evaluating early response to anti-cancer treatments. Despite these useful applications, there are few methods for non-invasively measuring tumor extracellular pH, and none are routinely used
Externí odkaz:
https://doaj.org/article/6f775603ae284967b008fa378f78c0f7
Publikováno v:
Perspectives: Policy and Practice in Higher Education. :1-10
Autor:
Ashraf Ali, Shatila Sarwar, Dylan R. Pollard, Zhen Wei, Ruigang Wang, Xinyu Zhang, Andrew J. Adamczyk
Publikováno v:
The Journal of Physical Chemistry C. 126:17011-17024
Publikováno v:
Medical Education. 56:1163-1173
Uncertainty is an inevitable part of medical practice. An ability to tolerate uncertainty is viewed as a key competency across many health-care systems. Poor uncertainty tolerance (UT) has been linked to negative outcomes including reduced psychologi
Autor:
Chris T. Williamson, Rowan Miller, Helen N. Pemberton, Samuel E. Jones, James Campbell, Asha Konde, Nicholas Badham, Rumana Rafiq, Rachel Brough, Aditi Gulati, Colm J. Ryan, Jeff Francis, Peter B. Vermulen, Andrew R. Reynolds, Philip M. Reaper, John R. Pollard, Alan Ashworth, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Mutations in the BAF SWI/SNF complex subunits are frequent in cancers but selective therapeutic approaches are not available yet. Here, the authors demonstrate that defects ofARID1Aand other subunits sensitizes cancer cells to the DNA checkpoint kina
Externí odkaz:
https://doaj.org/article/e641244f3cf24d9e87d1e6540b5b48bf
Autor:
Kumar Sanjiv, Anna Hagenkort, José Manuel Calderón-Montaño, Tobias Koolmeister, Philip M. Reaper, Oliver Mortusewicz, Sylvain A. Jacques, Raoul V. Kuiper, Niklas Schultz, Martin Scobie, Peter A. Charlton, John R. Pollard, Ulrika Warpman Berglund, Mikael Altun, Thomas Helleday
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3407-3416 (2016)
Externí odkaz:
https://doaj.org/article/358a7d08f38141fcb0e96d5b50776480
Autor:
Yves Pommier, James H. Doroshow, Joel Morris, John R. Pollard, Peter Charlton, Julie Jones, Christopher S. Barnes, Philip M. Reaper, Thomas D. Pfister, Pinar Ormanoglu, Rajarshi Guha, Scott E. Martin, Rozenn Jossé
Supplemental Table S2. Top Ingenuity canonical pathways enriched by genes among the top RSA candidates (42 genes, RSA p{less than or equal to} 0.001). A Benjamini-Hochberg multiple testing correction p-value < 0.05 was used as a cutoff.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469715f3a5d024f2d91d55b219cc822d
https://doi.org/10.1158/0008-5472.22401159
https://doi.org/10.1158/0008-5472.22401159
Autor:
Yves Pommier, James H. Doroshow, Joel Morris, John R. Pollard, Peter Charlton, Julie Jones, Christopher S. Barnes, Philip M. Reaper, Thomas D. Pfister, Pinar Ormanoglu, Rajarshi Guha, Scott E. Martin, Rozenn Jossé
Supplemental Figure S3. The ATR inhibitor VX-970 sensitizes COLO 205 colorectal cancer cells to SN-38. COLO 205 cells were treated with VX-970 and SN-38 for 48h and cytotoxicity was measured by MTS assay. A. Synergy was analyzed by Bliss at the 95% i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa10e9a174c5873965794cdda021aa58
https://doi.org/10.1158/0008-5472.22401165.v1
https://doi.org/10.1158/0008-5472.22401165.v1
Autor:
Yves Pommier, James H. Doroshow, Joel Morris, John R. Pollard, Peter Charlton, Julie Jones, Christopher S. Barnes, Philip M. Reaper, Thomas D. Pfister, Pinar Ormanoglu, Rajarshi Guha, Scott E. Martin, Rozenn Jossé
Camptothecin and its derivatives, topotecan and irinotecan, are specific topoisomerase I (Top1) inhibitors and potent anticancer drugs killing cancer cells by producing replication-associated DNA double-strand breaks, and the indenoisoquinoline LMP-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::297eee12d5369e297d2f3811ea11d401
https://doi.org/10.1158/0008-5472.c.6505776
https://doi.org/10.1158/0008-5472.c.6505776