Development and Optimization of a Machine-Learning Prediction Model for Acute Desquamation After Breast Radiation Therapy in the Multicenter REQUITE Cohort

Autor: Mahmoud Aldraimli, PhD, Sarah Osman, PhD, Diana Grishchuck, MSc, Samuel Ingram, MSc, Robert Lyon, PhD, Anil Mistry, MSc, Jorge Oliveira, PhD, Robert Samuel, MBChB, Leila E.A. Shelley, PhD, Daniele Soria, PhD, Miriam V. Dwek, PhD, Miguel E. Aguado-Barrera, MD, PhD, David Azria, MD, Jenny Chang-Claude, PhD, Alison Dunning, PhD, Alexandra Giraldo, MD, Sheryl Green, MD, Sara Gutiérrez-Enríquez, PhD, Carsten Herskind, PhD, Hans van Hulle, MD, Maarten Lambrecht, MD, Laura Lozza, MD, Tiziana Rancati, MSc, Victoria Reyes, MD, Barry S. Rosenstein, PhD, Dirk de Ruysscher, MD, Maria C. de Santis, MD, Petra Seibold, PhD, Elena Sperk, MD, R. Paul Symonds, MD, Hilary Stobart, Begoña Taboada-Valadares, MD, Christopher J. Talbot, PhD, Vincent J.L. Vakaet, MD, Ana Vega, PhD, Liv Veldeman, MD, PhD, Marlon R. Veldwijk, PhD, Adam Webb, PhD, Caroline Weltens, MD, Catharine M. West, PhD, Thierry J. Chaussalet, PhD, Tim Rattay, MBChB, PhD

Publikováno v: Advances in Radiation Oncology, Vol 7, Iss 3, Pp 100890- (2022)

Purpose: Some patients with breast cancer treated by surgery and radiation therapy experience clinically significant toxicity, which may adversely affect cosmesis and quality of life. There is a paucity of validated clinical prediction models for rad

Externí odkaz: https://doaj.org/article/496ce594114c42489a36163f25aae676

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Use of Angiotensin Converting Enzyme Inhibitors is Associated with Reduced Risk of Late Bladder Toxicity Following Radiotherapy for Prostate Cancer

Autor: Sarah L. Kerns, Ashley Amidon Morlang, Sharon M. Lee, Derick R. Peterson, Brian Marples, Hong Zhang, Kevin Bylund, Doug Rosenzweig, William Hall, Kim De Ruyck, Barry S. Rosenstein, Richard G. Stock, Antonio Gómez-Caamaño, Ana Vega, Paloma Sosa-Fajardo, Begoña Taboada-Valladares, Miguel E. Aguado-Barrera, Chris Parker, Liv Veldeman, Valérie Fonteyne, Renée Bultijnck, Christopher J. Talbot, R. Paul Symonds, Kerstie Johnson, Tim Rattay, Adam Webb, Maarten Lambrecht, Dirk de Ruysscher, Ben Vanneste, Ananya Choudhury, Rebecca M. Elliott, Elena Sperk, Carsten Herskind, Marlon R. Veldwijk, Tiziana Rancati, Barbara Avuzzi, Riccardo Valdagni, David Azria, Marie-Pierre Farcy Jacquet, Jenny Chang-Claude, Petra Seibold, Catharine West, Michelle Janelsins, Yuhchyau Chen, Edward Messing, Gary Morrow, Erik Briers, Alison Dunning, Rebecca M Elliott, Sara Gutiérrez-Enríquez, Dirk De Ruysscher, R Paul Symonds, Hilary Stobart, Tim Ward, Catharine M. West

Publikováno v: Radiother Oncol
Radiotherapy and Oncology, 168, 75-82. Elsevier Ireland Ltd

BACKGROUND AND PURPOSE: Genome-wide association studies (GWAS) of late hematuria following prostate cancer radiotherapy identified single nucleotide polymorphisms (SNPs) near AGT, encoding angiotensinogen. We tested the hypothesis that patients takin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0659b0fd46b11059e755f707e529ae5
https://europepmc.org/articles/PMC8986577/

Multi-centre technical evaluation of the radiation-induced lymphocyte apoptosis assay as a predictive test for radiotherapy toxicity

Autor: Carsten Herskind, Catharine M L West, Frederik Wenz, Chiara Batini, Marlon R. Veldwijk, Miriam Bierbaum, Elena Sperk, Christopher J. Talbot, R. Paul Symonds, A. Keller, Sheila Smith, Muriel Brengues, David Azria, Jenny Chang-Claude, Kerstie Johnson, Céline Bourgier

Publikováno v: Clinical and Translational Radiation Oncology, Vol 18, Iss, Pp 1-8 (2019)
Talbot, C J, Veldwijk, M R, Azria, D, Batini, C, Bierbaum, M, Brengues, M, Chang-Claude, J, Johnson, K, Keller, A, Smith, S, Sperk, E, Symonds, R P, Wenz, F, West, C M L, Herskind, C & Bourgier, C 2019, ' Multi-centre technical evaluation of the radiation-induced lymphocyte apoptosis assay as a predictive test for radiotherapy toxicity ', Clinical and translational radiation oncology, vol. 18, pp. 1-8 . https://doi.org/10.1016/j.ctro.2019.06.001
Clinical and Translational Radiation Oncology

Highlights • The RILA assay is the leading candidate biomarker for radiotherapy toxicity. • We describe work to standardise its use across multiple centres. • Patient factors including smoking and arthritis were found to affect RILA score. •

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6befbd58213940daaba84084f504fa72
http://www.sciencedirect.com/science/article/pii/S2405630819300278

Genetic Variants Predict Optimal Timing of Radiotherapy to Reduce Side-effects in Breast Cancer Patients

Autor: J. Chang-Claude, Sara Gutiérrez Enríquez, Jenny Chang-Claude, Hubert Thierens, Ana Vega, David Azria, Liv Veldeman, Karen S. Johnson, Riccardo Valdagni, Rebecca Elliott, C.J. Talbot, Alison M. Dunning, Tom Burr, Dirk De Ruysscher, R.P. Symonds, Frederik Wenz, A. Webb, Tim Rattay, Samuel Lavers, R. Paul Symonds, P. Seibold, Anthony J. Brookes, Martin Yuille, Philippe Lambin, Susan E Davidson, Barry S. Rosenstein, C. West, Tiziana Rancati, C. Kyriacou, A.-M. Critchley, Catharine M L West, Petra Seibold, Christopher J. Talbot

Publikováno v: Johnson, K, Chang-claude, J, Critchley, A, Kyriacou, C, Lavers, S, Rattay, T, Seibold, P, Webb, A, West, C, Symonds, R P, Talbot, C J, Azria, D, Brookes, A, Chang-claude, J, De Ruysscher, D, Dunning, A, Gutiérrez Enríquez, S, Lambin, P, Rancati, T, Rosenstein, B, Seibold, P, Symonds, R P, Thierens, H, Valdagni, R, Vega, A, Veldeman, L, Wenz, F & West, C 2019, ' Genetic Variants Predict Optimal Timing of Radiotherapy to Reduce Side-effects in Breast Cancer Patients ', Clinical Oncology, vol. 31, no. 1, pp. 9-16 . https://doi.org/10.1016/j.clon.2018.10.001

Aims Radiotherapy is an important treatment for many types of cancer, but a minority of patients suffer long-term side-effects of treatment. Multiple lines of evidence suggest a role for circadian rhythm in the development of radiotherapy late side-e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0796d0db8c6d3ec16489066efed382e
https://linkinghub.elsevier.com/retrieve/pii/S093665551830462X