Zobrazeno 1 - 10 of 212 pro vyhledávání: '"R Paul Robertson"'
1
Akademický článek
Islets Transplantation at a Crossroads - Need for Urgent Regulatory Update in the United States: Perspective Presented During the Scientific Sessions 2021 at the American Diabetes Association Congress
Autor: Piotr Witkowski, Louis H. Philipson, John B. Buse, R. Paul Robertson, Rodolfo Alejandro, Melena D. Bellin, Fouad Kandeel, David Baidal, Jason L. Gaglia, Andrew M. Posselt, Roi Anteby, Piotr J. Bachul, Yaser Al-Salmay, Kumar Jayant, Angelica Perez-Gutierrez, Rolf N. Barth, John J. Fung, Camillo Ricordi
Publikováno v: Frontiers in Endocrinology, Vol 12 (2022)
Clinical islet allotransplantation has been successfully regulated as tissue/organ for transplantation in number of countries and is recognized as a safe and efficacious therapy for selected patients with type 1 diabetes mellitus. However, in the Uni
Externí odkaz: https://doaj.org/article/8ce3c7aabdf24c8ebc54e4691f1ff99f
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2
Brief Review: Pancreatic Islet Transplantation for Type 1 Diabetes in Humans
Autor: R. Paul Robertson
Publikováno v: OBM Transplantation. :1-12
Pancreatic islet transplantation (ITx) has moved from the experimental phase of development to a position of an accepted and appropriate procedure to apply in clinical medicine. The primary indication for use of ITx is for management of dangerous and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92fa7647e28abe30292b9e6e3980e5ab
https://doi.org/10.21926/obm.transplant.2302184
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3
Akademický článek
Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function
Autor: Sudha S. Shankar, Douglas S. Lee, Ralph H. Raymond, Roberto A. Calle, Claudio Cobelli, Atalanta Ghosh, R. Paul Robertson, Hartmut Ruetten, Myrlene A. Staten, Darko Stefanovski, Adrian Vella, Sanya Whitaker, David A. Fryburg
Publikováno v: Contemporary Clinical Trials Communications, Vol 10, Iss , Pp 94-99 (2018)
Standard practice to minimize variability in beta cell function (BCF) measurement is to test in inpatient (IP) settings. IP testing strains trial subjects, investigators, and budgets. Outpatient (OP) testing may be a solution although there are few r
Externí odkaz: https://doaj.org/article/93654348a84b46b193cff126cf88a764
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4
Glucagon and Insulin Overview: An Odd Couple's History and Physiology
Autor: R Paul Robertson
Publikováno v: Journal of Endocrinology.
Glucagon is a peptide hormone that is produced primarily by the alpha cells in the islet of Langerhans in the pancreas, but also in intestinal enteroendocrine cells and in some neurons. Approximately 100 years ago several research groups discovered t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::963ca35fdbf310b813de6c3b568cf90f
https://doi.org/10.1530/joe-22-0224
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5
Evolution of Nrf2 Gene Expression in HIT-T15 β-Cells During Chronic Oxidative Stress and Glucose Toxicity
Autor: Tsehay Abebe, Lindsey Bogachus, Adithya Krishna Vegaraju, R Paul Robertson
Publikováno v: Journal of the Endocrine Society. 7
Context Chronic exposure of pancreatic islets to elevated glucose levels causes progressive declines in beta cell Pdx-1 and insulin gene expression, and glucose-induced insulin secretion. This has been shown to be associated with excessive islet reac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5acd3108630dfea0212a2bdbb25d7040
https://doi.org/10.1210/jendso/bvac178
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7
Nrf2 and Antioxidant Response in Animal Models of Type 2 Diabetes
Autor: R. Paul Robertson
Publikováno v: International Journal of Molecular Sciences. 24:3082
This perspective examines the proposition that chronically elevated blood glucose levels caused by type 2 diabetes (T2D) harm body tissues by locally generating reactive oxygen species (ROS). A feed-forward scenario is described in which the initial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b629bb0ba2c21dcdebbc56e36d436fbc
https://doi.org/10.3390/ijms24043082
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8
Akademický článek
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