Zobrazeno 1 - 10
of 167
pro vyhledávání: '"R Paul Johnson"'
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173929 (2017)
The live attenuated vaccine (LAV) SIVmac239Δnef (SIVΔnef) confers the best protection among all the vaccine modalities tested in rhesus macaque model of HIV-1 infection. This vaccine has a unique feature of time-dependent protection: macaques are n
Externí odkaz:
https://doaj.org/article/e3e10586a7514e319156f447e94d05ec
Autor:
Sama Adnan, R Keith Reeves, Jacqueline Gillis, Fay E Wong, Yi Yu, Jeremy V Camp, Qingsheng Li, Michelle Connole, Yuan Li, Michael Piatak, Jeffrey D Lifson, Wenjun Li, Brandon F Keele, Pamela A Kozlowski, Ronald C Desrosiers, Ashley T Haase, R Paul Johnson
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006104 (2016)
Defining the correlates of immune protection conferred by SIVΔnef, the most effective vaccine against SIV challenge, could enable the design of a protective vaccine against HIV infection. Here we provide a comprehensive assessment of immune response
Externí odkaz:
https://doaj.org/article/06b3afcb40fe45a695d045607398c274
Autor:
James M Billingsley, Premeela A Rajakumar, Michelle A Connole, Nadine C Salisch, Sama Adnan, Yury V Kuzmichev, Henoch S Hong, R Keith Reeves, Hyung-joo Kang, Wenjun Li, Qingsheng Li, Ashley T Haase, R Paul Johnson
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004740 (2015)
The onset of protective immunity against pathogenic SIV challenge in SIVΔnef-vaccinated macaques is delayed for 15-20 weeks, a process that is related to qualitative changes in CD8+ T cell responses induced by SIVΔnef. As a novel approach to charac
Externí odkaz:
https://doaj.org/article/5fbe518dbfca4582888711391c84f7e3
Autor:
Sama Adnan, Arnaud D Colantonio, Yi Yu, Jacqueline Gillis, Fay E Wong, Ericka A Becker, Michael Piatak, R Keith Reeves, Jeffrey D Lifson, Shelby L O'Connor, R Paul Johnson
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004633 (2015)
The live attenuated simian immunodeficiency virus (LASIV) vaccine SIVΔnef is one of the most effective vaccines in inducing protection against wild-type lentiviral challenge, yet little is known about the mechanisms underlying its remarkable protect
Externí odkaz:
https://doaj.org/article/8fd943c4d1fd42498617beb0f66b54b1
Autor:
Henoch Sangjoon Hong, Premeela eRajakumar, James Michael Billingsley, R. Keith eReeves, R Paul Johnson
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Human NK cells play a key role in mediating host immune responses against various infectious diseases. For practical reasons, the majority of the data on human NK cells has been generated using peripheral blood lymphocytes. In contrast, our knowledge
Externí odkaz:
https://doaj.org/article/e9a0ee9d88294603a7f1397ca7703793
Autor:
Arun K Sasikala-Appukuttan, Hyeon O Kim, Nikilyn J Kinzel, Jung Joo Hong, Anthony J Smith, Reece Wagstaff, Cavan Reilly, Michael Piatak, Jeffrey D Lifson, R Keith Reeves, R Paul Johnson, Ashley T Haase, Pamela J Skinner
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81623 (2013)
Live-attenuated SIV vaccines (LAVs) have been the most effective to date in preventing or partially controlling infection by wild-type SIV in non-human primate models of HIV-1 transmission to women acting by mechanisms of protection that are not well
Externí odkaz:
https://doaj.org/article/dab9cf6b95514747a0684e994a02c800
Autor:
Namita Rout, Justin Greene, Simon Yue, David O'Connor, R Paul Johnson, James G Else, Mark A Exley, Amitinder Kaur
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002928 (2012)
Chronic immune activation is a key determinant of AIDS progression in HIV-infected humans and simian immunodeficiency virus (SIV)-infected macaques but is singularly absent in SIV-infected natural hosts. To investigate whether natural killer T (NKT)
Externí odkaz:
https://doaj.org/article/58f62d0113d341cba13d7a99bc321c1a
Autor:
Michael D Alpert, Jackson D Harvey, W Anderson Lauer, R Keith Reeves, Michael Piatak, Angela Carville, Keith G Mansfield, Jeffrey D Lifson, Wenjun Li, Ronald C Desrosiers, R Paul Johnson, David T Evans
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002890 (2012)
Live-attenuated strains of simian immunodeficiency virus (SIV) routinely confer apparent sterilizing immunity against pathogenic SIV challenge in rhesus macaques. Understanding the mechanisms of protection by live-attenuated SIV may provide important
Externí odkaz:
https://doaj.org/article/a27a1df9350c44a1a97f7783c33d20e9
Autor:
Arnaud D Colantonio, Benjamin N Bimber, William J Neidermyer, R Keith Reeves, Galit Alter, Marcus Altfeld, R Paul Johnson, Mary Carrington, David H O'Connor, David T Evans
Publikováno v:
PLoS Pathogens, Vol 7, Iss 3, p e1001316 (2011)
Molecular interactions between killer immunoglobulin-like receptors (KIRs) and their MHC class I ligands play a central role in the regulation of natural killer (NK) cell responses to viral pathogens and tumors. Here we identify Mamu-A1*00201 (Mamu-A
Externí odkaz:
https://doaj.org/article/9c08f1e1496f4f9981d0ba1da7d7aa98
Autor:
Janine Kimpel, Stephen E Braun, Gang Qiu, Fay Eng Wong, Michelle Conolle, Jörn E Schmitz, Christian Brendel, Laurent M Humeau, Boro Dropulic, John J Rossi, Annemarie Berger, Dorothee von Laer, R Paul Johnson
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12357 (2010)
Although a variety of genetic strategies have been developed to inhibit HIV replication, few direct comparisons of the efficacy of these inhibitors have been carried out. Moreover, most studies have not examined whether genetic inhibitors are able to
Externí odkaz:
https://doaj.org/article/27adb019fa40424488d6bb9508d0c069