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Akademický článek

Pembrolizumab-induced vasculitis demonstrated by FDG-PET/CT

Autor: Tuan Vu, BS, Sophia R. O'Brien, MD, Shawn X. Ma, MD, Karthik M. Sundaram, MD, PhD, Austin R. Pantel, MD, MSTR

Publikováno v: Radiology Case Reports, Vol 19, Iss 9, Pp 3959-3961 (2024)

A 76-year-old man with a history of malignant pleural mesothelioma treated with pembrolizumab underwent FDG-PET/CT for restaging. The images demonstrated FDG uptake overlying the right hepatic and splenic artery, which were new from the previous FDG-

Externí odkaz: https://doaj.org/article/bd050e85a17d429ea7846dc8824e5c0c

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Akademický článek

Widespread micronodular hepatic metastases of neuroendocrine tumor detected by [68Ga]DOTATATE PET/CT

Autor: Julia C. D'Souza, MD, MS, Sophia R. O'Brien, MD, Zhaohai Yang, MD, PhD, Amr K. El Jack, MD, PhD, Austin R. Pantel, MD, MSTR

Publikováno v: Radiology Case Reports, Vol 18, Iss 2, Pp 481-485 (2023)

Neuroendocrine tumors (NET) encompass a diverse, heterogeneous group of neoplasms that originate from the secretory cells of the neuroendocrine system. These neoplasms typically express the somatostatin receptor (SSTR), which can be targeted by molec

Externí odkaz: https://doaj.org/article/5706b3e718554325a2f3fb07432f8b19

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Akademický článek

Novel applications of molecular imaging to guide breast cancer therapy

Autor: Christine E. Edmonds, Sophia R. O’Brien, David A. Mankoff, Austin R. Pantel

Publikováno v: Cancer Imaging, Vol 22, Iss 1, Pp 1-17 (2022)

Abstract The goals of precision oncology are to provide targeted drug therapy based on each individual’s specific tumor biology, and to enable the prediction and early assessment of treatment response to allow treatment modification when necessary.

Externí odkaz: https://doaj.org/article/a439119c34654ce38c2e2799c1a9447a

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Akademický článek

In vivo visualization of PARP inhibitor pharmacodynamics

Autor: Elizabeth S. McDonald, Austin R. Pantel, Payal D. Shah, Michael D. Farwell, Amy S. Clark, Robert K. Doot, Daniel A. Pryma, Sean D. Carlin

Publikováno v: JCI Insight, Vol 6, Iss 8 (2021)

BACKGROUND [18F]FluorThanatrace ([18F]FTT) is a radiolabeled poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi) that enables noninvasive quantification of PARP with potential to serve as a biomarker for patient selection for PARPi thera

Externí odkaz: https://doaj.org/article/d6ab613d6d334089b95b77f1f24d6e3c

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