Zobrazeno 1 - 10 of 14 pro vyhledávání: '"R P Oude Elferink"'
1
Akademický článek
Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein
Autor: R P Oude Elferink, R Ottenhoff, M van Wijland, C M Frijters, C van Nieuwkerk, A K Groen
Publikováno v: Journal of Lipid Research, Vol 37, Iss 5, Pp 1065-1075 (1996)
Mice in which the gene for mdr2 P-glycoprotein has been disrupted have a severe deficiency in biliary phospholipid and cholesterol secretion. We studied the relation between mdr2 gene expression and biliary lipid secretion with emphasis on the role o
Externí odkaz: https://doaj.org/article/85a1efec7d8740308a45863f328db40f
Zobrazit plný text záznamu
2
Akademický článek
Rapid association of unconjugated bilirubin with amorphous calcium phosphate.
Autor: C N van der Veere, B Schoemaker, R van der Meer, A K Groen, P L Jansen, R P Oude Elferink
Publikováno v: Journal of Lipid Research, Vol 36, Iss 8, Pp 1697-1707 (1995)
The association of unconjugated bilirubin (UCB) with amorphous calcium phosphate was studied in vitro. To this end UCB, solubilized in different micellar bile salt solutions, was incubated with freshly prepared calcium phosphate precipitate. It was d
Externí odkaz: https://doaj.org/article/1b2ac9cc444042e9be7af239686a7241
Zobrazit plný text záznamu
3
Role of MRP2 and GSH in intrahepatic cycling of toxins
Autor: Roelof Ottenhoff, R P Oude Elferink, D. R. de Waart, Christoph G. Dietrich
Publikováno v: Toxicology, 167(1), 73-81. Elsevier Ireland Ltd
MRP2 is a canalicular transporter in hepatocytes mediating the transport of a wide spectrum of amphipathic compounds. This includes organic anions but also compounds complexed with GSH as, e.g. alpha-naphthylisothiocyanate (ANIT) and arsenite. These
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc24812d57fe09eceac22cde423ec9f
https://doi.org/10.1016/s0300-483x(01)00459-0
Zobrazit plný text záznamu
4
Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
Autor: C C, Paulusma, M A, van Geer, R, Evers, M, Heijn, R, Ottenhoff, P, Borst, R P, Oude Elferink
Publikováno v: The Biochemical journal. 338
The canalicular multispecific organic anion transporter (cMOAT), a member of the ATP-binding cassette transporter family, mediates the transport of a broad range of non-bile salt organic anions from liver into bile. cMOAT-deficient Wistar rats (TR-)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0ce7f57727cf63eca27b3f448ea3cd8
https://pubmed.ncbi.nlm.nih.gov/10024515
Zobrazit plný text záznamu
5
Selective protein adduct formation of diclofenac glucuronide is critically dependent on the rat canalicular conjugate export pump (Mrp2)
Autor: S, Seitz, A, Kretz-Rommel, R P, Oude Elferink, U A, Boelsterli
Publikováno v: Chemical research in toxicology. 11(5)
Previous work demonstrates that the reactive acyl glucuronide of the nonsteroidal antiinflammatory drug diclofenac forms selective protein adducts in the liver, which may play a causal role in the pathogenesis of diclofenac-associated liver toxicity.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e8addea369e8d79ff7f3667663c17ad
https://pubmed.ncbi.nlm.nih.gov/9585482
Zobrazit plný text záznamu
7
Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis
Autor: T H, Mauad, C M, van Nieuwkerk, K P, Dingemans, J J, Smit, A H, Schinkel, R G, Notenboom, M A, van den Bergh Weerman, R P, Verkruisen, A K, Groen, R P, Oude Elferink
Publikováno v: The American journal of pathology. 145(5)
The mouse mdr2 gene (and its human homologue MDR3, also called MDR2) encodes a P-glycoprotein that is present in high concentration in the bile canalicular membrane of hepatocytes. The 129/OlaHsd mice with a homozygous disruption of the mdr2 gene (-/
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e01bb8e38a11a599a1af3fdd8361d2d9
https://pubmed.ncbi.nlm.nih.gov/7977654
Zobrazit plný text záznamu
8
Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter
Autor: R P, Oude Elferink, C T, Bakker, H, Roelofsen, E, Middelkoop, R, Ottenhoff, M, Heijn, P L, Jansen
Publikováno v: Hepatology (Baltimore, Md.). 17(3)
Transport of organic anions within hepatocytes and the possible involvement of intracellular vesicles were studied with fluorescence microscopy. For this purpose monochlorobimane, a nonfluorescent hydrophobic compound that readily permeates into cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54a4f8e30c16a8cc4c6ee29740e8d0c9
https://pubmed.ncbi.nlm.nih.gov/8444418
Zobrazit plný text záznamu
10
Secretion of a precursor form of lysosomal alpha-glucosidase from the brush border of human kidney proximal tubule cells
Autor: R P, Oude Elferink, J, Fransen, J, Klumperman, L A, Ginsel, J M, Tager
Publikováno v: European journal of cell biology. 50(2)
We have shown previously (R.P.J. Oude Elferink, E.M. Brouwer-Kelder, I. Surya, A. Strijland, M. Kroos, A.J.J. Reuser, J.M. Tager, Eur. J. Biochem. 139, 489-495 (1984)) that human urine contains considerable amounts of a precursor form of lysosomal al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42643bb6139031623432e97d24b8c308
https://pubmed.ncbi.nlm.nih.gov/2697557
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje