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Comparison of tethering and rolling of eosinophils and neutrophils through selectins and P-selectin glycoprotein ligand-1

Autor: K D Patel, R P McEver

Publikováno v: The Journal of Immunology. 159:4555-4565

We compared the abilities of selectins and the selectin ligand, P-selectin glycoprotein ligand-1 (PSGL-1), to support tethering and rolling of eosinophils and neutrophils under physiologic flow conditions. Eosinophils and neutrophils accumulated on P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a8e39703a06891014e172d9b0419ceb
https://doi.org/10.4049/jimmunol.159.9.4555

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L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity

Autor: L Tu, A Chen, M D Delahunty, K L Moore, S R Watson, R P McEver, T F Tedder

Publikováno v: The Journal of Immunology. 157:3995-4004

The selectins mediate cellular interactions by binding carbohydrate determinants present on a limited number of glycoprotein ligands. L-selectin binds multiple ligands expressed on endothelial cells, while P-selectin interacts exclusively with P-sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00106554918b7ec16750d08bb2fb18cb
https://doi.org/10.4049/jimmunol.157.9.3995

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P-selectin regulates platelet-activating factor synthesis and phagocytosis by monocytes

Autor: M R Elstad, T R La Pine, F S Cowley, R P McEver, T M McIntyre, S M Prescott, G A Zimmerman

Publikováno v: The Journal of Immunology. 155:2109-2122

Adhesion molecules on endothelial cells or platelets may regulate localization and activation of leukocytes at sites of tissue injury, infection, or thrombosis. In these studies, we found that human peripheral blood monocytes adhered specifically to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1db9f47e2a16f088f0a609f3331bbade
https://doi.org/10.4049/jimmunol.155.4.2109

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P-selectin mediates neutrophil rolling on histamine-stimulated endothelial cells

Autor: R. P. Mcever, C. W. Smith, O Abbassi, Larry V. McIntire, D. A. Jones

Publikováno v: Biophysical Journal. 65(4):1560-1569

In postcapillary venules, marginating neutrophils (PMNs) are often seen rolling along the vessel wall prior to stopping and emigrating. There is substantial evidence in vitro and in vivo that the adhesion receptors E- and L-selectin participate in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8596bfb6b146386fdd81e2a3fe0f6c1e

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Characterization of a specific ligand for P-selectin on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides

Autor: Sandra Diaz, Kevin L. Moore, S Ushiyama, Karin E. Norgard, N L Stults, Richard D. Cummings, R P McEver, Ajit Varki

Publikováno v: Journal of Biological Chemistry. 268:12764-12774

Lectin-carbohydrate recognition between the selectins and their ligands are among the earliest events in leukocyte recirculation, leukocyte recruitment into inflamed areas, and abnormal egress of leukocytes in diseases. Previously, we have described

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97d2a234d1cbd399a0b61e92c00d9aeb
https://doi.org/10.1016/s0021-9258(18)31454-6

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Platelet functions beyond hemostasis

Autor: S S, Smyth, R P, McEver, A S, Weyrich, C N, Morrell, M R, Hoffman, G M, Arepally, P A, French, H L, Dauerman, R C, Becker, Jeremy P, Wood

Publikováno v: Journal of thrombosis and haemostasis : JTH. 7(11)

Summary. Although their central role is in the prevention of bleeding, platelets probably contribute to diverse processes that extend beyond hemostasis and thrombosis. For example, platelets can recruit leukocytes and progenitor cells to sites of vas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7971ee576c94f25db453ffcd9cba7bc
https://pubmed.ncbi.nlm.nih.gov/19691483

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The selectin GMP-140 binds to sialylated, fucosylated lactosaminoglycans on both myeloid and nonmyeloid cells

Autor: K. L. Moore, Richard D. Cummings, Qun Zhou, Ajit Varki, David F. Smith, R. P. Mcever

Publikováno v: The Journal of Cell Biology

Granule membrane protein-140 (GMP-140) is an inducible receptor for myeloid leukocytes on activated platelets and endothelium. Like other selectins, GMP-140 recognizes specific oligosaccharide ligands. However, prior data on the nature of these ligan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0b8369d041cc185b8bf8115c39fe33
https://doi.org/10.1083/jcb.115.2.557

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