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Kinetic deuterium isotope effects on the N-demethylation of tertiary amides by cytochrome P-450

Autor: R P Hanzlik, L R Hall

Publikováno v: Journal of Biological Chemistry. 265:12349-12355

Liver microsomal cytochrome P-450 readily N-dealkylates N,N-dimethylamides. N-Methyl-N-hydroxymethyl amides were isolated as intermediates and characterized by gas chromatography-mass spectrometry as their trimethylsilyl ethers. Intramolecular kineti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6270bdf53014d4c0c08db7e2bf8ccef
https://doi.org/10.1016/s0021-9258(19)38353-x

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Selective Epoxidation of Terminal Double Bonds: 10,11-Epoxyfarnesyl Acetate

Autor: R. P. Hanzlik

Publikováno v: Organic Syntheses

Selective epoxidation of terminal double bonds: 10,11-epoxyfarnesyl acetate intermediate: Farnesyl acetate solvent: 100-ml. portions of petroleum ether intermediate: 10-Bromo-11-hydroxy-10,11-dihydrofarnesyl acetate product: 10,11-Epoxyfarnesyl aceta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::227670ac96b57343c4d4e55a47d4109d
https://doi.org/10.1002/0471264180.os056.24

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Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication

Autor: J S, Kong, S, Venkatraman, K, Furness, S, Nimkar, T A, Shepherd, Q M, Wang, J, Aubé, R P, Hanzlik

Publikováno v: Journal of medicinal chemistry. 41(14)

Human rhinovirus, the chief cause of the common cold, contains a positive-sense strand of RNA which is translated into a large polyprotein in infected cells. Cleavage of the latter to produce the mature viral proteins required for replication is cata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f28c43d007cdd1656e4a7cd06f9135e4
https://pubmed.ncbi.nlm.nih.gov/9651162

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Bromo(monohydroxy)phenyl mercapturic acids. A new class of mercapturic acids from bromobenzene-treated rats

Autor: J, Zheng, R P, Hanzlik

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 20(5)

Alkaline permethylation and GC/MS analysis of urinary mercapturic acids from rats given bromobenzene yielded several quinone-derived bromodimethoxythioanisole isomers as expected. Unexpectedly, seven bromomonomethoxythioanisole isomers were also obse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2da93223076a8ad766dbe7c283f23256
https://pubmed.ncbi.nlm.nih.gov/1358573

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Metabolism of dichlorobenzenes in organ cultured liver slices

Autor: R, Fisher, S, McCarthy, I G, Sipes, R P, Hanzlik, K, Brendel

Publikováno v: Advances in experimental medicine and biology. 283

A novel in vitro system was used to evaluate tissue specific toxicity. This system utilizes precision cut organ slices in dynamic organ culture and is viable for up to 24 hrs. The three isomers of dichlorobenzene were added to liver slices prepared f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33915c775d7198cda79b175296fd4642
https://pubmed.ncbi.nlm.nih.gov/2069046

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Metabolism of Dichlorobenzenes in Organ Cultured Liver Slices

Autor: S. McCarthy, R. P. Hanzlik, Klaus Brendel, I. G. Sipes, Robyn L. Fisher

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781468458794

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::726975c20e4d0285682288cba831c637
https://doi.org/10.1007/978-1-4684-5877-0_93

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Kinetic deuterium isotope effects on the N-demethylation of tertiary amides by cytochrome P-450

Autor: L R, Hall, R P, Hanzlik

Publikováno v: The Journal of biological chemistry. 265(21)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ba0caa82482a08efb5428ebd58fed50
https://pubmed.ncbi.nlm.nih.gov/2373695

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