Výsledky vyhledávání - "R P G van Heeswijk"

The Effect of ABCB1 Polymorphism on the Pharmacokinetics of Saquinavir Alone and in Combination with Ritonavir

Autor: C. J. L. la Porte, R P G van Heeswijk, Lizanne C. Beïque, Brian C. Foster, Gary Garber, D. W. Cameron, Y Li, Bobby M. Chauhan

Publikováno v: Clinical Pharmacology & Therapeutics. 82:389-395

This genotype panel study investigated the effect of ABCB1 polymorphism in exon 26 (C3435T), exon 21 (G2677T/A), and exon 12 (C1236T) on saquinavir pharmacokinetics and on the expression and activity of P-glycoprotein (P-gp) in peripheral blood monoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a35f45249b146757951efd0169bb36
https://doi.org/10.1038/sj.clpt.6100157

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Absence of circadian variation in the pharmacokinetics of lopinavir/ritonavir given as a once daily dosing regimen in HIV-1-infected patients

Autor: Marc Bourbeau, G. E. Garber, Isabelle Seguin, R. P. G. van Heeswijk, Pierre Giguère, D. W. Cameron

Publikováno v: British Journal of Clinical Pharmacology. 59:398-404

Aims To compare the pharmacokinetics of lopinavir/ritonavir (LPV/r) 800/200 mg administered once daily in the morning compared with the evening. Methods This was a randomized, two-way, cross-over study in HIV+ subjects. In each subject the pharmacoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375459d90d8c0f3bdc05e25fec6911fa
https://doi.org/10.1111/j.1365-2125.2005.02337.x

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Bedaquiline: a review of human pharmacokinetics and drug-drug interactions

Autor: R. P. G. van Heeswijk, Brian Dannemann, Richard M. W. Hoetelmans

Publikováno v: The Journal of antimicrobial chemotherapy. 69(9)

Bedaquiline has recently been approved for the treatment of pulmonary multidrug-resistant tuberculosis (TB) as part of combination therapy in adults. It is metabolized primarily by the cytochrome P450 isoenzyme 3A4 (CYP3A4) to a less-active N-monodes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9890eec9bdef2e9a844bfbf9ba44fd6b
https://pubmed.ncbi.nlm.nih.gov/24860154

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Combination of Protease Inhibitors for the Treatment of HIV-1-Infected Patients: A Review of Pharmacokinetics and Clinical Experience

Autor: J. H. Beijnen, R. M. W. Hoetelmans, R. P. G. Van Heeswijk, J. W. Mulder, Al Veldkamp, Pieter L. Meenhorst, J. M. A. Lange

Publikováno v: Antiviral Therapy. 6:201-229

The use of highly active antiretroviral therapy, the combination of at least three different antiretroviral drugs for the treatment of HIV-1 infection, has greatly improved the prognosis for HIV-1-infected patients. The efficacy of a combination of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b1a52711fac3e9b6fe647c80f237501
https://doi.org/10.1177/135965350200600401

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Once-daily dosing of saquinavir and low-dose ritonavir in HIV-1-infected individuals: a pharmacokinetic pilot study

Autor: R. M. W. Hoetelmans, J. W. Mulder, Pieter L. Meenhorst, R. P. G. Van Heeswijk, J. M. A. Lange, Jos H. Beijnen, A.I. Veldkamp

Publikováno v: AIDS (London, England), 14(9), F103-F110. Lippincott Williams and Wilkins

Objective: To investigate the steady-state pharmacokinetics of a once-daily dosing regimen of saquinavir soft gelatin capsules in combination with a low dose of ritonavir in HIV-1-infected individuals. Design: Open-label, multi-dose, pharmacokinetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f169ce187bfb9c5c0cc4cc166e655d9b
https://doi.org/10.1097/00002030-200006160-00003

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Paclitaxel in the treatment of human immunodeficiency virus 1-associated Kaposi's sarcoma – drug-drug interactions with protease inhibitors and a nonnucleoside reverse transcriptase inhibitor: a case report study

Autor: J. W. Mulder, R. P. G. Van Heeswijk, M. Inghels, Richard M. W. Hoetelmans, J. H. Beijnen, Pieter L. Meenhorst, V. R. Nannan Panday

Publikováno v: Cancer Chemotherapy and Pharmacology. 43:516-519

Purpose: To describe the pharmacokinetics of paclitaxel and to investigate the interaction potential with protease inhibitors (indinavir, ritonavir, saquinavir) and the nonnucleoside reverse transcriptase inhibitor nevirapine, for which strong theore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f64fcf9a506363f7524340f7ceaabb0
https://doi.org/10.1007/s002800050932

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Co-Trimoxazole and Stavudine Interference in a High-Performance Liquid Chromatographic Analysis for Didanosine in Human Plasma

Autor: R. M. W. Hoetelmans, Pieter L. Meenhorst, J. W. Mulder, Monique Profijt, Jos H. Beijnen, R. P. G. Van Heeswijk

Publikováno v: Therapeutic Drug Monitoring. 20:669-672

Recently, the authors were confronted with interference of stavudine and co-trimoxazole when analyzing the antiretroviral drug didanosine (ddI) in plasma of HIV-1-infected patients using reverse-phase high-performance liquid chromatography with ultra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8558b119e4669695da9b9648c0e41700
https://doi.org/10.1097/00007691-199812000-00015

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Differential effects of tipranavir plus ritonavir on atorvastatin or rosuvastatin pharmacokinetics in healthy volunteers

Autor: C. J. L. la Porte, Patricia Barditch-Crovo, Lawrence S. Lee, Mabrouk Elgadi, Charles Flexner, Edward J. Fuchs, Paul A. Pham, R P G van Heeswijk, Peter J. Piliero, D. W. Cameron, John P. Sabo

Publikováno v: Antimicrobial agents and chemotherapy. 53(10)

To identify pharmacokinetic (PK) drug-drug interactions between tipranavir-ritonavir (TPV/r) and rosuvastatin and atorvastatin, we conducted two prospective, open-label, single-arm, two-period studies. The geometric mean (GM) ratio was 1.37 (90% conf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7dac73d03b2a8ba58c2642802c48c3
https://pubmed.ncbi.nlm.nih.gov/19667285

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Rapid quantification of delavirdine, a novel non-nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with fluorescence detection

Autor: J. M. A. Lange, J. W. Mulder, A.I. Veldkamp, R. P. G. Van Heeswijk, Pieter L. Meenhorst, J. H. Beijnen, R. M. W. Hoetelmans

Publikováno v: Journal of chromatography. B, Biomedical sciences and applications, 727(1-2), 151-157. Elsevier BV

Delavirdine is a novel non-nucleoside reverse transcriptase inhibitor for the treatment of HIV-1-infected patients. A simple and rapid high-performance liquid chromatographic method for the quantification of delavirdine in human plasma suitable for d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824f09f4e73c51501ee3bef43217dd48
https://pubmed.ncbi.nlm.nih.gov/10360434

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