Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R P Elferink"'
Autor:
Ulrich Bolder, R P Elferink, M. J. Kothe, Piter J. Bosma, Coen C. Paulusma, Guido N. J. Tytgat, Irene van Bokhoven, Conny T. Bakker, Jan van Marle
Publikováno v:
Hepatology (Baltimore, Md.), 31(3), 684-693. John Wiley and Sons Ltd
We have studied regulation of the multidrug resistance protein 2 (mrp2) during bile duct ligation (BDL) in the rat. In hepatocytes isolated after 16, 48, and 72 hours of BDL, mrp2-mediated dinitrophenyl-glutathione (DNP-GS) transport was decreased to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288c654ac3cf0f71655bf739f0172b52
https://doi.org/10.1002/hep.510310319
https://doi.org/10.1002/hep.510310319
Publikováno v:
Journal of clinical investigation, 102(9), 1749-1757. The American Society for Clinical Investigation
The journal of clinical investigation, 102, 1749-1757. The American Society for Clinical Investigation
The journal of clinical investigation, 102, 1749-1757. The American Society for Clinical Investigation
Cholestasis is associated with hypercholesterolemia and ap- pearance of the abnormal lipoprotein X (LpX) in plasma. Using mice with a disrupted Mdr2 gene, we tested the hy- pothesis that LpX originates as a biliary lipid vesicle. Mdr2- deficient mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac2b7399a51f6a3946f3a2120871b03
https://doi.org/10.1172/jci3597
https://doi.org/10.1172/jci3597
Autor:
Frank Baas, Marcel Kool, Guido N. J. Tytgat, Coen C. Paulusma, F. Ter Borg, Piter J. Bosma, R.J. Scheper, R P Elferink, George L. Scheffer, Piet Borst
Publikováno v:
Hepatology (Baltimore, Md.), 25(6), 1539-1542. John Wiley and Sons Ltd
Hepatology, 25, 1539-1542. John Wiley and Sons Ltd
Paulusma, C C, Kool, M, Bosma, P J, Scheffer, G L, Terborg, F, Scheper, R J, Tytgat, G N J, Borst, P, Baas, F & Elferink, P J O 1997, ' A mutation in the human canalicular multispecific organic anion transportergene causes the Dubin-Johnson syndrome ', Hepatology, vol. 25, pp. 1539-1542 . https://doi.org/10.1002/hep.510250635
Hepatology, 25, 1539-1542. John Wiley and Sons Ltd
Paulusma, C C, Kool, M, Bosma, P J, Scheffer, G L, Terborg, F, Scheper, R J, Tytgat, G N J, Borst, P, Baas, F & Elferink, P J O 1997, ' A mutation in the human canalicular multispecific organic anion transportergene causes the Dubin-Johnson syndrome ', Hepatology, vol. 25, pp. 1539-1542 . https://doi.org/10.1002/hep.510250635
The human Dubin-Johnson syndrome (DJS) is a rare autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. Patients have impaired hepatobiliary transport of non-bile salt organic anions. A highly similar phenotype has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c103bf2f90b2cb4302688d16bd05e901
https://hdl.handle.net/11245/1.138381
https://hdl.handle.net/11245/1.138381
Autor:
G L, Scheffer, M, Kool, M, Heijn, M, de Haas, A C, Pijnenborg, J, Wijnholds, A, van Helvoort, M C, de Jong, J H, Hooijberg, C A, Mol, M, van der Linden, J M, de Vree, P, van der Valk, R P, Elferink, P, Borst, R J, Scheper
Publikováno v:
Cancer research. 60(18)
Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1 P-glycoprotein (P-gp) or the multidrug resistance protein 1 (MRP1). MDR3 P-gp is a close homolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ad3f3eca287171f5e83e051df87f576
https://pubmed.ncbi.nlm.nih.gov/11016657
https://pubmed.ncbi.nlm.nih.gov/11016657
Publikováno v:
Journal of lipid research. 40(11)
Class III P-glycoproteins (Pgps) mediate biliary phosphatidylcholine (PC) secretion. Recent findings that class I P-glycoproteins are able to transport several short-chain phospholipid analogues raises questions about the role of these Pgps in physio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::084c4bd273b2ce8941247a5a3e1f685b
https://pubmed.ncbi.nlm.nih.gov/10552998
https://pubmed.ncbi.nlm.nih.gov/10552998
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 11(1)
The small apical (canalicular) domains of hepatocytes form a luminal meshwork of tubules between adjacent hepatocytes and are the sites of primary bile formation. Organic compounds are transported across this membrane domain against high concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3cc0387caf6fa359618b8fd3086414d
https://pubmed.ncbi.nlm.nih.gov/9034162
https://pubmed.ncbi.nlm.nih.gov/9034162
Publikováno v:
Hepatology (Baltimore, Md.), 24(3), 620-626. John Wiley and Sons Ltd
The aim of this study was to test a possible form of therapy that could be used in the management of unconjugated hyperbilirubinemia. We hypothesized that unconjugated bilirubin (UCB) can permeate the intestinal wall and can thus be secreted with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98817929523d1e5058ca917cc59986cb
https://pubmed.ncbi.nlm.nih.gov/8781334
https://pubmed.ncbi.nlm.nih.gov/8781334
Publikováno v:
Hepatology (Baltimore, Md.). 21(6)
The hepatocanalicular transport of a large number of organic anions, such as bilirubin glucuronides and glutathione conjugates in the rat, is mediated by an adenosine triphosphate (ATP)-dependent transport system, which is termed canalicular multispe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c406a3e6be481a4b092fa244df15dc6
https://pubmed.ncbi.nlm.nih.gov/9021974
https://pubmed.ncbi.nlm.nih.gov/9021974
Publikováno v:
American journal of physiology, 265(3 Part 1), G445-G452. American Physiological Society
The in vivo biliary secretion of a number of organic anions in mutant TR- rats was studied. The secretion of bilirubin glucuronide (BG), the glutathione conjugate of bromosulfophthalein, dibromosulfophthalein, and indocyanine green was reduced to 2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a840fced7cad7f15c85275a7f930317
https://pure.amc.nl/en/publications/preserved-organic-anion-transport-in-mutant-tr-rats-with-a-hepatobiliary-secretion-defect(8893c7fc-c38f-44e1-9e14-b57f6b8c1102).html
https://pure.amc.nl/en/publications/preserved-organic-anion-transport-in-mutant-tr-rats-with-a-hepatobiliary-secretion-defect(8893c7fc-c38f-44e1-9e14-b57f6b8c1102).html
Autor:
Pulak Lahiri, Peter L. M. Jansen, Namita Roy Chowdhury, Jayanta Roy Chowdhury, H. H.G. Van Es, M. Lederstein, Piter J. Bosma, T. J. Huang, R P Elferink, Peter F. Whitington
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 6(10)
Crigler-Najjar syndrome, type I (CN-I) is a potentially lethal disorder characterized by severe unconjugated hyperbilirubinemia resulting from a recessively inherited deficiency of hepatic UDP-glucuronosyl-transferase (UGT) activity toward bilirubin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b28b6cd59500c43da3de630c3278c4
https://pubmed.ncbi.nlm.nih.gov/1634050
https://pubmed.ncbi.nlm.nih.gov/1634050