Zobrazeno 1 - 10
of 61
pro vyhledávání: '"R P Bucy"'
Autor:
Elizabeth Colston, Dennis Grasela, David Gardiner, R Pat Bucy, Blisse Vakkalagadda, Alan J Korman, Israel Lowy
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198158 (2018)
Expression of cytotoxic T-lymphocyte antigen 4 (CTLA-4), a negative regulator of T-cell function, is increased in chronic HIV-1 infection. It was hypothesized that CTLA-4 blockade may enhance immune response to HIV-1 and result in better control of v
Externí odkaz:
https://doaj.org/article/525eddc677e74f3d8d4fb079ad37dda4
Autor:
Charles O Elson, Robert P Mccabe, Kenneth W Beagley, Almaz Sharmanov, Steven L Brandwein, Ben U Ridwan, Casey Weaver, R Patrick Bucy, Jerry R Mcghee, John Sundberg, Edward Birkenmeier
Publikováno v:
Canadian Journal of Gastroenterology, Vol 10, Iss 2, Pp 105-109 (1996)
Although the etiology of inflammatory bowel disease (IBD) remains unknown, a major working hypothesis is that it represents a dysregulated immune response to common enteric bacterial antigens. Until recently there has been a relative dearth of experi
Externí odkaz:
https://doaj.org/article/72d319328af041cc9bbf7d555e7e4f62
The Potency of Allospecific Tregs Cells Appears to Correlate With T Cell Receptor Functional Avidity
Autor:
R. P. Bucy, Lesley A. Smyth, Jys Tsang, Y. Chen, Paul K.H. Tam, Giovanna Lombardi, D. Li, Robert I. Lechler, Kulachelvy Ratnasothy, Kwok-Fai Lau
Publikováno v:
American Journal of Transplantation. 11:1610-1620
CD4(+) CD25(+) regulatory T cells (T(reg) cells) are an attractive adoptive cell therapy in mediating transplantation tolerance. T-cell receptor (TcR) activation is critical for T(reg) function, suggesting that the TcR avidity of T(reg) cells used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c2dcf7d74ad95b781f31561eb3bb66
https://doi.org/10.1111/j.1600-6143.2011.03650.x
https://doi.org/10.1111/j.1600-6143.2011.03650.x
Autor:
George Spencer-Green, R. P. Bucy, W. Winn Chatham, Michael E. Weinblatt, Larry W. Moreland, K.M. Mohler
Publikováno v:
Clinical Immunology. 103:13-21
Etanercept, a recombinant human tumor necrosis factor (TNF) inhibitor that binds both soluble and cell-bound TNF, has been shown to reduce disease activity and inhibit joint destruction when administered to patients with rheumatoid arthritis (RA). Be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f51c38c9ab867e0e3c4c1f1fd6d4a96
https://doi.org/10.1006/clim.2001.5183
https://doi.org/10.1006/clim.2001.5183
Autor:
Richard D. Hockett, R. P. Bucy, Michael S. Saag, T. B. Wakefield, J. M. Kilby, Greg Sfakianos
Publikováno v:
Journal of Virological Methods. 87:1-12
HIV infection leads to loss of CD4 T cells and development of AIDS in most individuals without treatment. While disease progression during HIV infection correlates with the plasma viral load, much less is known about the levels of HIV vDNA. This pape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd51c3423734d19100f693c7268993f9
https://doi.org/10.1016/s0166-0934(00)00139-7
https://doi.org/10.1016/s0166-0934(00)00139-7
Autor:
John E. Volanakis, S B Digerness, S Niwas, Y.S. Babu, A Agrawal, J. M. Kilpatrick, Alexander J. Szalai, John F. Kearney, R P Bucy
Publikováno v:
Scopus-Elsevier
We induced reverse passive Arthus (RPA) reactions in the skin of rodents and found that the contribution of complement to immune complex-mediated inflammation is species specific. Complement was found to be necessary in rats and guinea pigs but not i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f55192f058286bc1a947a3ce4fa848c
https://doi.org/10.4049/jimmunol.164.1.463
https://doi.org/10.4049/jimmunol.164.1.463
Autor:
Daniel L. Georges, Adriana Weinberg, John L. Fahey, Howard M. Lederman, Michael M. Lederman, Y. Mizrachi, A. Craiu, R. P. Bucy, James M. Reuben, Jennifer L. Devers, John Spritzler, Joan N. Siegel, Susan Stehn, Charles A. Dinarello, Mary A Fletcher, Robert S. Wallis, Michael Wade, Savita Pahwa
Publikováno v:
Clinical Diagnostic Laboratory Immunology. 5:556-560
Measures of immune function have become increasingly important as endpoints in AIDS clinical trials, with respect to both modulation and reconstitution of immunity by experimental therapies. Measurement of immune function in this setting requires the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb95c2aabae9ea1015e04e47495b2cb
https://doi.org/10.1128/cdli.5.4.556-560.1998
https://doi.org/10.1128/cdli.5.4.556-560.1998
Publikováno v:
Transplantation. 63:876-885
BACKGROUND: Donor alloantigen-specific tolerance to vascularized allografts can be induced by several treatments, but the immunological mechanism(s) of these effects remain unclear. One hypothesis is that allograft unresponsiveness is correlated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfef2e29096532db3e2adca381d6ccfd
https://doi.org/10.1097/00007890-199703270-00014
https://doi.org/10.1097/00007890-199703270-00014
Autor:
Kazuhito Honjo, Guo-Qiang Huang, J. A. Lemons, L. Karr, Kenneth M. Murphy, Casey T. Weaver, Jimin Li, R. P. Bucy, D. Carter
Publikováno v:
Proceedings of the National Academy of Sciences. 92:7565-7569
CD4+ T cells from alpha beta-T-cell receptor transgenic mice were analyzed for coexpression of cytokine mRNAs during phenotype development using a double-label in situ hybridization technique. T cells that produced cytokines in the primary response w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a095b07db239d281b44345a2aea87870
https://doi.org/10.1073/pnas.92.16.7565
https://doi.org/10.1073/pnas.92.16.7565
Publikováno v:
The Journal of Immunology. 154:6644-6654
We compared the degrees of depletion and the rates of recovery of CD4+ T cells in young and old mice given a single injection of an anti-CD4 (GK1.5) mAb. We found that in young mice the CD4+ population of T cells was completely depleted from the peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a95a11eced3998dc823fbeda29727fc
https://doi.org/10.4049/jimmunol.154.12.6644
https://doi.org/10.4049/jimmunol.154.12.6644