Zobrazeno 1 - 10 of 65 pro vyhledávání: '"R P, Warrell"'
1
Acute promyelocytic leukemia cell line AP-1060 established as a cytokine-dependent culture from a patient clinically resistant to all-trans retinoic acid and arsenic trioxide
Autor: R. P. Warrell, Elisabeth Paietta, Linda A. Cannizzaro, Fabien Guidez, Arthur Zelent, S. H. Kim, W. Ding, Da Cheng Zhou, Robert E. Gallagher, K. H. Ramesh, Y. Sun
Publikováno v: Leukemia. 18:1258-1269
AP-1060 is a newly established acute promyelocytic leukemia (APL) cell line from a multiple-relapse patient clinically resistant to both all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). The line was initially derived as a granulocyte colony
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bc99a724de926f8b0caf4a836328ed
https://doi.org/10.1038/sj.leu.2403372
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2
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia
Autor: L Z, He, T, Tolentino, P, Grayson, S, Zhong, R P, Warrell, R A, Rifkind, P A, Marks, V M, Richon, P P, Pandolfi
Publikováno v: The Journal of clinical investigation. 108(9)
Acute promyelocytic leukemia (APL) is associated with chromosomal translocations, invariably involving the retinoic acid receptor alpha (RAR alpha) gene fused to one of several distinct loci, including the PML or PLZF genes, involved in t(15;17) or t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91b4bc8a13039d597663a3926eeebc22
https://pubmed.ncbi.nlm.nih.gov/11696570
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4
Arsenicals in hematologic cancers
Autor: S C, Novick, R P, Warrell
Publikováno v: Seminars in oncology. 27(5)
Arsenic trioxide (AT) has been the object of renewed interest as a therapeutic since studies in China in the late 1980s confirmed its efficacy in the treatment of acute promyelocytic leukemia (APL). These studies have been replicated in the West, wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb2d36e65b0da54f07d51beafa728482
https://pubmed.ncbi.nlm.nih.gov/11049017
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5
Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins
Autor: E M, Rego, L Z, He, R P, Warrell, Z G, Wang, P P, Pandolfi
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 97(18)
Acute promyelocytic leukemia (APL) is associated with chromosomal translocations always involving the RARalpha gene, which variably fuses to one of several distinct loci, including PML or PLZF (X genes) in t(15;17) or t(11;17), respectively. APL in p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8dac547296b8f62074c1fed0840899a6
https://pubmed.ncbi.nlm.nih.gov/10954752
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6
Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis
Autor: G J, Roboz, S, Dias, G, Lam, W J, Lane, S L, Soignet, R P, Warrell, S, Rafii
Publikováno v: Blood. 96(4)
Arsenic trioxide (As(2)O(3)) has recently been used successfully in the treatment of acute promyelocytic leukemia and has been shown to induce partial differentiation and apoptosis of leukemic cells in vitro. However, the mechanism by which As(2)O(3)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2f4f03e371c03f9d092549fb9ce77c0
https://pubmed.ncbi.nlm.nih.gov/10942401
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8
Initial clinical trial of a high-affinity retinoic acid receptor ligand (LGD1550)
Autor: S L, Soignet, V A, Miller, D G, Pfister, B J, Bienvenu, R, Ho, B A, Parker, S A, Amyotte, A, Cato, R P, Warrell
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(5)
Retinoids mediate their biological response by binding to specific nuclear receptors, including retinoic acid receptors and/or retinoid X receptors. LGD1550 is a high-affinity ligand for all three retinoic acid receptors (alpha, beta, and gamma isofo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4cf6c096170b4b12e5bb8c9bb091b0ce
https://pubmed.ncbi.nlm.nih.gov/10815891
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9
Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner
Autor: Z G, Wang, R, Rivi, L, Delva, A, König, D A, Scheinberg, C, Gambacorti-Passerini, J L, Gabrilove, R P, Warrell, P P, Pandolfi
Publikováno v: Blood. 92(5)
Inorganic arsenic trioxide (As2O3) and the organic arsenical, melarsoprol, were recently shown to inhibit growth and induce apoptosis in NB4 acute promyelocytic leukemia (APL) and chronic B-cell leukemia cell lines, respectively. As2O3 has been propo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0814ff0a903521b36a1774a2170a16bd
https://pubmed.ncbi.nlm.nih.gov/9716575
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10
Gallium nitrate for the treatment of bone metastases
Autor: R P, Warrell
Publikováno v: Cancer. 80
Gallium nitrate was originally developed as an antineoplastic agent; however, further studies have revealed that this drug has extremely potent effects on turnover of bone, and that low doses can be used to reduce bone resorption. Like the bisphospho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b60fb43250570908e94e757a9c8f9fbc
https://pubmed.ncbi.nlm.nih.gov/9362436
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