Association between P-pulmonale and respiratory morbidity in COPD: a secondary analysis of the BLOCK-COPD trial

Autor: R. Chad Wade, Takudzwa Mkorombindo, Sharon X. Ling, Erika. S. Helgeson, David M. MacDonald, Krystle Pew, Helen Voelker, Vera Bittner, Ken M. Kunisaki, Matthew R. Lammi, Mark. T. Dransfield

Publikováno v: BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-8 (2023)

Abstract Rationale Pulmonary hypertension (PH) in COPD confers increased risk of exacerbations (ECOPD). Electrocardiogram (ECG) indicators of PH are prognostic both in PH and COPD. In the Beta-Blockers for the Prevention of Acute Exacerbations of COP

Externí odkaz: https://doaj.org/article/6ed5fa44150a45abae40378220b57c83

BOugie or stylet in patients UnderGoing Intubation Emergently (BOUGIE): protocol and statistical analysis plan for a randomised clinical trial

Autor: Li Wang, Tamer Hudali, Megan Moore, Robert Mitchell, Wesley H Self, Todd W Rice, Matthew W Semler, Kate O’Connor, David B Page, Christopher Hughes, Swati Gulati, Jonathan D Casey, Derek W Russell, Derek J Vonderhaar, William S Stigler, John Whittle, Jason R West, Kevin W Gibbs, Janna S Landsperger, Sarah W Robison, Itay Bentov, Matthew E Prekker, Christopher John Lindsell, David Janz, John P Gaillard, Bradley Lloyd, Sheetal Gandotra, Anna Altz-Stamm, Cristina Bardita, Mary Clay Boone, Joe W Chiles, Kristina Collins, Abby Drescher, Kevin G Dsouza, Janna Dunn, Stacy Ejem, Josh Gautney, Nicole Harris, Savannah Herder, R Chad Wade, Rutwij Joshi, Daniel Kelmenson, Anne Merrill Mason, Scott R Merriman, Takudzwa Mkorombindo, Jada Nowak, Lisa Sarratt, Tabitha Stewart, Kadambari Vijaykumar, Gina White, Micah R Whitson, Christopher Barnes, Andrew M Walters, Adit A Ginde, Brian Driver, Stacy A Trent, Lane M Smith, AM Joffe, Michelle P Howell, Steven Mitchell, Andrew Latimer, Kevin Doerschug, Vikas Koppurapu, Alicia K Cupelo, Paige DeVries, Sally Dye, Andrea Fletcher, Christopher S Gray, Kevin High, Michael C Kurz, Carol L Lyle, Justin Oeth, Erika LW Rice, Alexandra Schick, Jamie Stang, Nathaniel D Westphal, Tak Watase, Vijay Krishnamoorthy, Raquel R Bartz, William C Fox, Bret D Alvis, Stephanie C Demasi, Laura E Goyack, Kristy K Ford, Trevor S Mattox, Sheylan D Patel, G Bruno Pereira, Anthony Defebio, Jennifer Friedel, Feysel Mohamed, Karina Nava, Angela Otoo, Christian Perez, Cori Withers

Publikováno v: BMJ Open, Vol 11, Iss 5 (2021)

Introduction Intubation-related complications are less frequent when intubation is successful on the first attempt. The rate of first attempt success in the emergency department (ED) and intensive care unit (ICU) is typically less than 90%. The bougi

Externí odkaz: https://doaj.org/article/aab5d5812dfa4bdeb60c4fceaa87b09e

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

Autor: M. Amaral, D. B. Kokh, J. Bomke, A. Wegener, H. P. Buchstaller, H. M. Eggenweiler, P. Matias, C. Sirrenberg, R. C. Wade, M. Frech

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

An understanding of the dynamics of drug binding and unbinding processes is important for drug discovery. Here, the authors give insights into the binding mechanism of small drug-like molecules to human Hsp90 by combining thermodynamics and kinetics

Externí odkaz: https://doaj.org/article/8cad50c6a80c4f728aa29dd8ed5e414e

Structural Basis for the Varying Propensities of Different Amino Acids To Adopt the Collagen Conformation.

Autor: Raman S. Sundar, R. Gopalakrishnan, R. C. Wade, V. Subramanian

Publikováno v: Journal of Physical Chemistry B; Mar2011, Vol. 115 Issue 11, p2593-2607, 15p

Alternative splicing generates variants in important functional domains of human slow skeletal troponin T

Autor: R, Gahlmann, A B, Troutt, R P, Wade, P, Gunning, L, Kedes

Publikováno v: The Journal of biological chemistry. 262(33)

We provide the first nucleotide sequence information for the slow isoform of troponin T (TnT). Sequence and hybridization analyses revealed that a single slow TnT gene present in the human genome gives rise to at least two different slow TnT variants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8cad5d421ba7f4410ed46b5de4ed4feb
https://pubmed.ncbi.nlm.nih.gov/2824479