Zobrazeno 1 - 10
of 60
pro vyhledávání: '"R P, Messner"'
Autor:
R R, Graham, C D, Langefeld, P M, Gaffney, W A, Ortmann, S A, Selby, E C, Baechler, K B, Shark, T C, Ockenden, K E, Rohlf, K L, Moser, W M, Brown, S E, Gabriel, R P, Messner, R A, King, P, Horak, J T, Elder, P E, Stuart, S S, Rich, T W, Behrens
Publikováno v:
Arthritis Research
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to a wide range of self-antigens. Recent genome screens have implicated numerous chromosomal regions as potential SLE susceptibility
Publikováno v:
The Journal of rheumatology. 25(3)
To recruit a large cohort of sibling pairs with systemic lupus erythematosus (SLE) as a clinical and biologic resource for genetic studies in SLE.Complementary approaches were used to identify suitable families. The study was advertised in the newsle
Autor:
R P, Messner
Publikováno v:
The Journal of rheumatology. 24(5)
Publikováno v:
The Journal of laboratory and clinical medicine. 123(3)
Mice infected with the Tucson strain of coxsackievirus B1 (CVB1T) develop chronic T cell-mediated polymyositis that is manifest as the acute infection resolves and is characterized by hindquarter weakness and muscle inflammation. This model system wa
Publikováno v:
The Journal of laboratory and clinical medicine. 122(5)
Rate constants (k1 through k4) describing complement-mediated and Fc gamma receptor-mediated components of immune clearance were serially determined in BALB/c mice fed ethanol, 10%, in drinking water, for 24 weeks. A branched series, first order reac
Publikováno v:
The Journal of rheumatology. 19(9)
The presence of antinuclear antibodies was determined in female laboratory workers with varying degrees of exposure to blood from patients with systemic lupus erythematosus (SLE). Subjects recruited from SLE research laboratories and a membership ros
Publikováno v:
The Journal of laboratory and clinical medicine. 117(3)
Although several studies have reported abnormal immune clearance in murine models of systemic lupus erythematosus (SLE), a consistent defect in mononuclear phagocyte function in SLE-prone mice has not been described. To evaluate the mechanism(s) of i
Autor:
T J, Thomas, R P, Messner
Publikováno v:
The Journal of rheumatology. 18(2)
We studied the effects of difluoromethylornithine (DFMO), an experimental drug that inhibits the biosynthesis of natural polyamines, on anti-DNA antibody production, immunoglobulin synthesis, proteinuria, and blood urea nitrogen (BUN) in lupus-prone
Publikováno v:
The Journal of laboratory and clinical medicine. 115(6)
The mechanisms of immune clearance in normal BALB/c mice were studied by kinetic analysis of the clearance of immunoglobulin-sensitized red blood cells. A rate equation, derived from a model for the clearance of sensitized cells, was used to quantita
Publikováno v:
Journal of Clinical Investigation. 80:499-506
Chronic inflammatory myositis similar to human polymyositis occurs in mice after infection with a strain of Coxsackievirus B 1 (CVB 1). To investigate the role of T cells in the pathogenesis of this disorder, we compared disease expression in T cell-