Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R P, Hertzberg"'
Autor:
S. M. Hech, Francis L. McCabe, Jeffrey C. Boehm, M. J. Caranfa, K. G. Holden, Randall K. Johnson, William D. Kingsbury, G. Gallagher, Leo F. Faucette, D. R. Jakas, R. P. Hertzberg
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::becacefba76198d61f05fc55e0783e26
https://doi.org/10.1002/chin.199122254
https://doi.org/10.1002/chin.199122254
Autor:
P B, Taylor, J S, Culp, C, Debouck, R K, Johnson, A D, Patil, D J, Woolf, I, Brooks, R P, Hertzberg
Publikováno v:
The Journal of biological chemistry. 269(9)
Inophyllums are novel non-nucleoside inhibitors of human immunodeficiency virus (HIV) type 1 reverse transcriptase identified through an enzyme screening program and isolated from the plant Calophyllum inophyllum. The kinetics of reverse transcriptas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fab018372cb5e00805119baf316b8258
https://pubmed.ncbi.nlm.nih.gov/7509800
https://pubmed.ncbi.nlm.nih.gov/7509800
Autor:
R D, Woessner, W K, Eng, G A, Hofmann, D J, Rieman, F L, McCabe, R P, Hertzberg, M R, Mattern, K B, Tan, R K, Johnson
Publikováno v:
Oncology research. 4(11-12)
A subline of P388 leukemia made 10-fold resistant to camptothecin (CPT) by serial passage in drug-treated mice was adapted to growth in tissue culture and made hyper-resistant to CPT by passage in the presence of increasing concentrations of the drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4844eab3b0692c07e775249a361df698
https://pubmed.ncbi.nlm.nih.gov/1338578
https://pubmed.ncbi.nlm.nih.gov/1338578
Autor:
R P, Hertzberg, R W, Busby, M J, Caranfa, K G, Holden, R K, Johnson, S M, Hecht, W D, Kingsbury
Publikováno v:
The Journal of biological chemistry. 265(31)
Camptothecin (CPT) binds reversibly to, and thereby stabilizes, the cleavable complex formed between DNA and topoisomerase I. The nature of the interaction of CPT with the DNA-topoisomerase I binary complex was studied by the use of two affinity labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8db79853b395231f273ac236cc3b58b8
https://pubmed.ncbi.nlm.nih.gov/2172250
https://pubmed.ncbi.nlm.nih.gov/2172250
Autor:
W K, Eng, F L, McCabe, K B, Tan, M R, Mattern, G A, Hofmann, R D, Woessner, R P, Hertzberg, R K, Johnson
Publikováno v:
Molecular pharmacology. 38(4)
A camptothecin-resistant subline of P388 leukemia (P388/CPT) was developed by repeated transplantation of P388 cells in mice treated with therapeutic doses of camptothecin. In mice bearing the resistant tumor, a maximally tolerated dose of camptothec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5c3567591d1dc3d4a8e492ca97350e5
https://pubmed.ncbi.nlm.nih.gov/2172765
https://pubmed.ncbi.nlm.nih.gov/2172765
Autor:
L H, Hurley, T, Reck, D E, Thurston, D R, Langley, K G, Holden, R P, Hertzberg, J R, Hoover, G, Gallagher, L F, Faucette, S M, Mong
Publikováno v:
Chemical research in toxicology. 1(5)
The DNA alkylation and sequence specificity of a group of natural and synthetic pyrrolo-[1,4]benzodiazepines [P(1,4)Bs] were evaluated by using an exonuclease III stop assay, and the results were compared with in vitro and in vivo biological potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef7415767c69e7e5da2ff47a8ae08a2
https://pubmed.ncbi.nlm.nih.gov/2979741
https://pubmed.ncbi.nlm.nih.gov/2979741
Publikováno v:
Chemischer Informationsdienst. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::131dd79a493228619f087f66451c6e1a
https://doi.org/10.1002/chin.198545209
https://doi.org/10.1002/chin.198545209
Autor:
R. P. HERTZBERG, P. B. DERVAN
Publikováno v:
Chemischer Informationsdienst. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d12cd88fe44f40a3b95d442efc7aaa5
https://doi.org/10.1002/chin.198216334
https://doi.org/10.1002/chin.198216334
Publikováno v:
Chemischer Informationsdienst. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::300d23dc9a4be597775f927d7214ef8f
https://doi.org/10.1002/chin.198030262
https://doi.org/10.1002/chin.198030262
Autor:
F H, Drake, G A, Hofmann, S M, Mong, J O, Bartus, R P, Hertzberg, R K, Johnson, M R, Mattern, C K, Mirabelli
Publikováno v:
Cancer research. 49(10)
Merbarone has previously been shown to have antitumor activity of unknown mechanism in P388 and L1210 tumor models (A. D. Brewer et al., Biochem. Pharmacol., 34:2047-2050, 1985) and is currently undergoing Phase I clinical trials. Here we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a78cb95becd1181d8c02f6a6ba067a0
https://pubmed.ncbi.nlm.nih.gov/2540903
https://pubmed.ncbi.nlm.nih.gov/2540903