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Akademický článek

Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D2 (300,000 IU)

Autor: A. Sankaralingam, R. Roplekar, C. Turner, R. N. Dalton, G. Hampson

Publikováno v: Journal of Osteoporosis, Vol 2014 (2014)

Background. Vitamin D is important for bone health, although high loading doses have been associated with an increase in fracture risk. The mechanisms remain uncertain. Aim. We hypothesize that supraphysiological concentrations of 1,25 (OH)2 vitamin

Externí odkaz: https://doaj.org/article/eb27113d4ba445d797d6cdc00fbb748b

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Biological variation of cardiac troponins in chronic kidney disease

Autor: Andrew Sutton, Elizabeth Brettell, Kamlesh Khunti, F S Morris, Ryan S Ottridge, Jonathan Barratt, Alice J Sitch, Tracy Pellatt-Higgins, Paul Cockwell, Gillian Eaglestone, Maarten W. Taal, R A Jones, Edmund J. Lamb, Paul E. Stevens, Jonathan J Deeks, Philip A. Kalra, R N Dalton, Claire C. Sharpe

Publikováno v: Annals of clinical biochemistry. 57(2)

Background Patients with chronic kidney disease often have increased plasma cardiac troponin concentration in the absence of myocardial infarction. Incidence of myocardial infarction is high in this population, and diagnosis, particularly of non ST-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358015f6f10ce22725b08ce94140271a
https://pubmed.ncbi.nlm.nih.gov/32024371

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Markers of renal tubular dysfunction measured annually do not predict risk of microalbuminuria in the first few years after diagnosis of Type I diabetes

Autor: R N Dalton, H. A. W. Neil, David B. Dunger, T. Konopelska-Bahu, Carl Schultz

AIMS/HYPOTHESIS: Early detection of risk of microalbuminuria could prevent early renal damage. We investigated whether urine retinol binding protein and N-acetyl-glucosaminidase could predict the risk of microalbuminuria in a large cohort of children

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04708043a8df46340b7091b2fd5f67a
https://ora.ox.ac.uk/objects/uuid:3f5a0272-6a65-4162-ade6-a1788c9c19de

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Risk of nephropathy can be detected before the onset of microalbuminuria during the early years after diagnosis of type 1 diabetes

Autor: H. A. W. Neil, R N Dalton, Carl Schultz, David B. Dunger

OBJECTIVE: The early detection of a rise in albumin excretion within the normal range could permit early intervention to prevent the development of microalbuminuria (MA) in genetically susceptible subjects with type 1 diabetes. In the Oxford Regional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cccd2ddfcc01ae589a29c6ffb6a7e4ee
https://doi.org/10.2337/diacare.23.12.1811

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Freezing method affects the concentration and variability of urine proteins and the interpretation of data on microalbuminuria

Autor: C. J. Schultz, R. N. Dalton, C. Turner, H. A. W. Neil, D. B. Dunger, for the Oxford Regional Prospective Group

Aims. Microalbuminuria and, to a lesser extent, renal tubular proteins are widely used in the early detection of incipient nephropathy in diabetes mellitus. Recent reports have indicated detrimental effects of storage at - 20°C on urine proteins. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27207cc239dd2b2d66053ce06032dc52
https://doi.org/10.1046/j.1464-5491.2000.00200.x

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Urinary markers of renal inflammation in adolescents with Type 1 diabetes mellitus and normoalbuminuria

Autor: Heather N. Reich, R. N. Dalton, Denis Daneman, Rahim Moineddin, Yesmino Elia, R. Dekker, Farid H. Mahmud, Etienne Sochett, David B. Dunger, James W. Scholey, David Z.I. Cherney

Publikováno v: Diabetic Medicine. 29:1297-1302

Diabet. Med. 29, 1297–1302 (2012) Abstract Aims Patients with the highest albumin:creatinine ratio within the normal range are at an increased risk for developing microalbuminuria. The mechanistic basis for this is unknown, but may be related to re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a4190f38cee8db04b395d0da5cff968
https://doi.org/10.1111/j.1464-5491.2012.03651.x

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Asymmetric dimethylarginine in young people with Type 1 diabetes: a paradoxical association with HbA1c

Autor: David B. Dunger, M. L. Marcovecchio, Barry Widmer, R. N. Dalton, Charles Turner

Publikováno v: Diabetic Medicine. 28:685-691

Diabet. Med. 28, 685–691 (2011) Abstract Aims Asymmetric dimethylarginine (ADMA) is an independent risk factor for cardiovascular disease and its concentrations are increased in several diseases, including diabetes. However, there is limited inform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c37daa94588ae2ac2a435982c109120
https://doi.org/10.1111/j.1464-5491.2011.03252.x

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Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes

Autor: H. A. W. Neil, John A. Todd, Julie Edge, Barry Widmer, Carlo L. Acerini, Jason D. Cooper, R. N. Dalton, A. T. Prevost, C. P. Schwarze, M. L. Marcovecchio, Timothy Barrett, David B. Dunger, Julian P.H. Shield

Publikováno v: Diabetologia. 52:1173-1181

AIMS/HYPOTHESIS: The relationship between BP and microalbuminuria in young people with type 1 diabetes is not completely clear. As microalbuminuria is preceded by a gradual rise in albumin excretion within the normal range, we hypothesised that ambul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ab6d66f223b2b3ecb97ac765a696a6
https://doi.org/10.1007/s00125-009-1327-6

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Unchanged incidence of microalbuminuria in children with type 1 diabetes since 1986: a UK based inception cohort

Autor: Barry Widmer, R N Dalton, David B. Dunger, Rakesh Amin

Publikováno v: Archives of Disease in Childhood. 94:258-262

To prospectively determine the change in prevalence of microalbuminuria in relation to changes in glycaemic control in children diagnosed with type 1 diabetes between 1986 and 1996.Prospective observational study of an inception cohort.The geographic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9879d83e0c3f0aa0d1060f28df69c81
https://doi.org/10.1136/adc.2008.144337

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Ethnicity of children with homozygous c.985A>G medium-chain acyl-CoA dehydrogenase deficiency: findings from screening approximately 1.1 million newborn infants

Autor: M. Downing, G. T. N. Besley, M Cortina-Borja, J Leonard, J Oerton, M Henderson, Carol Dezateux, A Green, R N Dalton, Javaria M Khalid, Brage S. Andresen

Publikováno v: Khalid, J M, Oerton, J, Cortina-Borja, M, Andresen, B S, Besley, G, Dalton, R N, Downing, M, Green, A, Henderson, M, Leonard, J, Dezateux, C & UK Collaborative Study of Newborn Screening for MCADD 2008, ' Ethnicity of children with homozygous c.985A >G medium-chain acyl-CoA dehydrogenase deficiency: findings from screening approximately 1.1 million newborn infants ', Journal of Medical Screening, vol. 15, no. 3, pp. 112-7 . https://doi.org/10.1258/jms.2008.008043

Objectives It has been suggested that homozygous c.985A>G medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a disease of White ethnic origin but little is known regarding its ethnic distribution. We estimated ethnic-specific homozygous c.985A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdecf89e46160c1be955eb7127f531cc
https://doi.org/10.1258/jms.2008.008043

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