Zobrazeno 1 - 10
of 22
pro vyhledávání: '"R N, Upton"'
Publikováno v:
Clinical pharmacology and therapeutics. 99(4):405-418
Dashboard systems for clinical decision support integrate data from multiple sources. These systems, the newest in a long line of dose calculators and other decision support tools, utilize Bayesian approaches to fully individualize dosing using infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c0497ca7795c84d57f3ff244afcfad
https://doi.org/10.1002/cpt.334
https://doi.org/10.1002/cpt.334
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 27:625-629
SUMMARY 1. An acute in vivo hindlimb skeletal muscle preparation was developed in anaesthetized sheep in order to facilitate studies of the effects of altered blood flow states on drug kinetics in skeletal muscle. 2. A continuous index of blood flow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca099fab17a60c5c9fac9908e9a62d94
https://doi.org/10.1046/j.1440-1681.2000.03304.x
https://doi.org/10.1046/j.1440-1681.2000.03304.x
Autor:
H H, Villesen, D J R, Foster, R N, Upton, L L, Christrup, A A, Somogyi, A, Martinez, C, Grant
Publikováno v:
British journal of pharmacology. 149(6)
At present there are few data regarding the rate and extent of brain-blood partitioning of the opioid active metabolite of morphine, morphine-6-glucuronide (M6G). In this study the cerebral kinetics of M6G were determined, after a short-term intraven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3d0898347f912bab0ad56f04e5ccd08
https://pubmed.ncbi.nlm.nih.gov/17016501
https://pubmed.ncbi.nlm.nih.gov/17016501
Publikováno v:
Anaesthesia. 56(8)
Pharmacokinetic modelling of estimated central nervous system concentrations was used to devise the optimal mixture of morphine and alfentanil for the treatment of postoperative pain. Modelling revealed that an intravenous opioid pain protocol using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9ce2859e90d2dd00336b0fc6588221a
https://pubmed.ncbi.nlm.nih.gov/11493236
https://pubmed.ncbi.nlm.nih.gov/11493236
Publikováno v:
Acta physiologica Scandinavica. 172(3)
This study evaluated the relative importance of perfusion and diffusion mechanisms in compartmental models of blood : tissue inert gas exchange in skeletal muscle. Nitrous oxide kinetics in a hind limb skeletal muscle bed were determined during and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c278e2829664b1dc7bde6fce8ea299a3
https://pubmed.ncbi.nlm.nih.gov/11472303
https://pubmed.ncbi.nlm.nih.gov/11472303
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 28(2)
The cerebral pharmacokinetics and pharmacodynamics of midazolam and diazepam were examined in chronically instrumented sheep via measurements of their arterio-venous concentration difference across the brain during and after 2-min i.v. infusions. Dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::494dd5a5787ee17b9d43c15cdce5ef60
https://pubmed.ncbi.nlm.nih.gov/11381567
https://pubmed.ncbi.nlm.nih.gov/11381567
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(3)
The temporal relationship between the systemic and myocardial concentrations of magnesium and some of its acute cardiovascular effects were examined after short i.v. infusion administration of magnesium (30 mmol over 2 min) in five awake chronically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d17582436bdcb02b022499e1ae8b9ac6
https://pubmed.ncbi.nlm.nih.gov/11356944
https://pubmed.ncbi.nlm.nih.gov/11356944
Autor:
R N, Upton
Publikováno v:
Biopharmaceuticsdrug disposition. 21(2)
The blood concentration of a drug at steady state can be calculated from the ratio of infusion rate over the total body drug clearance. When the blood is assumed to be a homogenous pool, the clearance is not usually referenced to any particular site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1724ab803cbd43dfa653fb8cc00021a6
https://pubmed.ncbi.nlm.nih.gov/11100908
https://pubmed.ncbi.nlm.nih.gov/11100908
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 27(3)
Conventional compartmental pharmacokinetic analysis may provide inaccurate prediction of drug concentrations after rapid i.v. administration. To examine this, compartment and effect compartment analysis was applied to measured arterial and brain conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93690ea84eecaacfb36c0d8b67ad9253
https://pubmed.ncbi.nlm.nih.gov/10728494
https://pubmed.ncbi.nlm.nih.gov/10728494
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 26(6)
This study aimed to evaluate the relative importance of diffusion-limited vs. perfusion-limited mechanisms in compartmental models of blood-tissue inert gas exchange in the brain. Nitrous oxide concentrations in arterial and brain efferent blood were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4cae5d3c0eefe5ef6769b30f2239e66
https://pubmed.ncbi.nlm.nih.gov/10485079
https://pubmed.ncbi.nlm.nih.gov/10485079