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Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane

Autor: G. Yanni, M Nabil, Gabriel S. Panayi, R N Poston, M R Farahat

Publikováno v: Annals of the Rheumatic Diseases. 53:315-322

OBJECTIVES--Cytokines, released from mononuclear cells (MNC) are mediators of joint destruction in rheumatoid arthritis (RA). The mechanisms of action of gold salts used in the treatment of RA are unknown. The aim of this study was to investigate cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af92760dc4fc23613c291fbbee6f18bb
https://doi.org/10.1136/ard.53.5.315

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Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis

Autor: Gabriel S. Panayi, R N Poston, M. N.M.R. Farahat, G. Yanni

Publikováno v: Annals of the Rheumatic Diseases. 52:870-875

OBJECTIVES--To compare, by immunohistochemistry, the cellular and cytokine profile in rheumatoid arthritis (RA) and osteoarthritis (OA) synovial membranes (SMs). Synovium was obtained at knee arthroplasty from 10 patients with RA and 10 with OA. METH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5130cfa1d2c6283955dc9ea5a2cac4
https://doi.org/10.1136/ard.52.12.870

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Protein nitration in cutaneous inflammation in the rat: essential role of inducible nitric oxide synthase and polymorphonuclear leukocytes

Autor: S A B, Greenacre, F A C, Rocha, A, Rawlingson, S, Meinerikandathevan, R N, Poston, E, Ruiz, B, Halliwell, S D, Brain

Publikováno v: British journal of pharmacology. 136(7)

1: We have examined the relationship between neutrophil accumulation, NO(*) production and nitrated protein levels in zymosan-mediated inflammation in rat skin in vivo. 2: Rats were anaesthetized and cutaneous inflammation was induced by zymosan (inj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b1c0e2c9e3ffdd01e99600ee342f876
https://pubmed.ncbi.nlm.nih.gov/12145098

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Plasma concentrations of reputed tumor-associated soluble CD44 isoforms (v5 and v6) in smokers are dose related and decline on smoking cessation

Autor: D A, Scott, J A, Stapleton, R M, Palmer, R F, Wilson, G, Sutherland, P Y, Coward, G, Gustavsson, E W, Odell, R N, Poston

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 9(11)

There is some evidence to suggest that smoking may affect circulating levels of CD44 (sCD44) molecules. Therefore, we investigated the effect of smoking on the circulating level of sCD44 by comparing the change in total sCD44, sCD44v5, and sCD44v6 co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff14342e9e65ca963ac3e1eb31c4dbe9
https://pubmed.ncbi.nlm.nih.gov/11097229

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Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1

Autor: R R, Johnson-Tidey, J L, McGregor, P R, Taylor, R N, Poston

Publikováno v: The American journal of pathology. 144(5)

P-selectin (GMP-140) is an adhesion molecule present within endothelial cells that is rapidly translocated to the cell membrane upon activation, where it mediates endothelial-leukocyte interactions. Immunohistochemical analysis of human atherosclerot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81a4c13aceb2054a4df1fe8436d2203b
https://pubmed.ncbi.nlm.nih.gov/7513951

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The immunohistochemical heterogeneity of atheroma macrophages: comparison with lymphoid tissues suggests that recently blood-derived macrophages can be distinguished from longer-resident cells

Autor: R N Poston, I F Hussain

Publikováno v: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 41(10)

We studied the antigenic markers of macrophages (Mphs) in atherosclerotic human arteries by immunohistochemistry and compared them with the patterns in Mph subpopulations of tonsil and lymph node, which are also described. The staining of atheroma in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b0c985f17147d1274c2dad8644e1b8
https://pubmed.ncbi.nlm.nih.gov/7504008

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Expression of vascular cell adhesion molecule-1 in normal and inflamed synovium

Autor: L S, Wilkinson, J C, Edwards, R N, Poston, D O, Haskard

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 68(1)

The intercellular adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) has been implicated in a number of interactions between leukocytes and cells of lymphoid and connective tissue, including endothelial cells. Such interactions within synov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2bb87a3aa073ac6a4086d1561f4863e5
https://pubmed.ncbi.nlm.nih.gov/7678661

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Expression of intercellular adhesion molecule-1 in atherosclerotic plaques

Autor: R N, Poston, D O, Haskard, J R, Coucher, N P, Gall, R R, Johnson-Tidey

Publikováno v: The American journal of pathology. 140(3)

Immunohistochemistry of human atherosclerotic arteries demonstrates expression of the intercellular adhesion molecule-1 (ICAM-1) on endothelial cells, macrophages, and smooth muscle cells of the plaques. Normal arterial endothelial cells and intimal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4e8b8d58b72fba37ad8515d97304de5
https://pubmed.ncbi.nlm.nih.gov/1372160

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