Zobrazeno 1 - 10
of 73
pro vyhledávání: '"R N, Pinckard"'
Publikováno v:
Journal of Lipid Research, Vol 25, Iss 7, Pp 753-757 (1984)
Silica and C18 reverse phase high performance liquid chromatography (HPLC) were used to fractionate synthetic molecular species of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC) and semi-synthetic platelet-activating factor (PAF) synthesized
Externí odkaz:
https://doaj.org/article/42a3eaed816d45669cb8ace73aac2a20
Publikováno v:
Journal of Lipid Research, Vol 25, Iss 2, Pp 198-208 (1984)
A facile route to the semi-synthesis of acetyl glycerylether phosphoethanolamine and, subsequently, its choline analogue (platelet-activating factor) has been developed. In essence, this technique takes advantage of the fact that the phosphatidyletha
Externí odkaz:
https://doaj.org/article/9b660cdf789c4ed9a3344aa76b20a8b3
Publikováno v:
Journal of Lipid Research, Vol 30, Iss 6, Pp 929-937 (1989)
A novel, facile, and sensitive method for the quantitative and complete structure-proof analysis of platelet-activating factor (PAF) and other glycerophospholipids is described. 1-O-Alkyl/acyl-2-acyl-3-glycerophospholipids were treated with heptafluo
Externí odkaz:
https://doaj.org/article/98ce17b0e55640f2980e971a3352c872
Autor:
R. N Pinckard, Thomas J. Prihoda
Publikováno v:
Journal of Leukocyte Biology. 59:219-228
Alkyl-PAF induced two components of polymorphonuclear leukocyte (PMN) pruning for enhanced fMLP- and rC5a-induced superoxide anion (O2−) production. Component A priming had a shallow, linear alkyl-PAF concentration-response slope (10 pM–1 nM), an
Publikováno v:
Biological Mass Spectrometry. 22:559-564
The electron capture mass spectrometric response of pentafluorobenzoyl ester derivatives of platelet-activating factor alkyl chain homologs has been found to be inversely proportional to their alkyl chain length. This phenomenon was observed when eit
Autor:
R N Pinckard, H J Showell, R Castillo, C Lear, R Breslow, L M McManus, D S Woodard, J C Ludwig
Publikováno v:
The Journal of Immunology. 148:3528-3535
The phlogistic actions of six molecular species of platelet-activating factor (PAF) (1-O-alkyl-PAF homologs, 16:0-, 18:0- and 18:1-alkyl-PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC) and their respective 1-acyl-PAF analog counterparts,
Autor:
R. N Pinckard, Linda M. McManus
Publikováno v:
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 11(2)
PAF, or platelet-activating factor, is a family of structurally related phospholipids (1-O-alkyl/acyl/alkenyl-2-acetylsn-glycero-3-phosphocholine) which possesses a wide spectrum of potent pro-inflammatory actions. These phospholipids are synthesized
Agonist-dependent failure of neutrophil function in diabetes correlates with extent of hyperglycemia
Publikováno v:
Journal of leukocyte biology. 70(3)
Inexplicable controversies with regard to possible functional defects of neutrophilic polymorphonuclear leukocytes (PMNs) in diabetes persist. The purpose of the present study was to elucidate the relative effectiveness of several PMN agonists in sti
Publikováno v:
Clinical reviews in allergy. 12(4)
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 69(6)
The existence and potential (patho)physiologic significance of PAF molecular heterogeneity can no longer be summarily dismissed or ignored. While significant advances in the chemistry of PAF have been made, the (patho)physiologic behaviors of most of