Zobrazeno 1 - 10
of 201
pro vyhledávání: '"R N, Maini"'
Autor:
S E Ross, R O Williams, L J Mason, C Mauri, L Marinova-Mutafchieva, A M Malfait, R N Maini, M Feldmann
Rolipram is a type IV phosphodiesterase inhibitor that suppresses inflammation and TNF-alpha production. As anti-TNF-alpha therapy is effective in rheumatoid arthritis, we investigated the effect of rolipram on collagen-induced arthritis (CIA), a mur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609b96953e854c731bc57d75d0a43f59
https://ora.ox.ac.uk/objects/uuid:f11ac8cf-3038-49c7-a826-6a1cad86707e
https://ora.ox.ac.uk/objects/uuid:f11ac8cf-3038-49c7-a826-6a1cad86707e
Cytokine expression was investigated in synovial cell cultures isolated from diseased joints of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Tumour necrosis factor alpha (TNF alpha) was produced spontaneously at high levels by bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef7433fde7dd9619a301eeeb960f047
https://ora.ox.ac.uk/objects/uuid:ae79a2a3-8206-4538-b2c9-79fe35dad7f8
https://ora.ox.ac.uk/objects/uuid:ae79a2a3-8206-4538-b2c9-79fe35dad7f8
Following many years of research using isolated human tissues and animal models, sufficient knowledge concerning rheumatoid arthritis has accumulated so that novel immunotherapies have been proposed. Biological agents are being tested in clinical tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d9c8807d9fd31a8f568865305e6d0d
https://ora.ox.ac.uk/objects/uuid:6c7559b2-b025-450a-8cf7-8ae0acc2c29c
https://ora.ox.ac.uk/objects/uuid:6c7559b2-b025-450a-8cf7-8ae0acc2c29c
Tumor necrosis factor alpha (TNF alpha) is a cytokine with many biological functions of relevance to inflammatory disease. Although only one of several inflammatory mediators produced in abundance in rheumatoid arthritis (RA), experimental data sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a53d248110f57ca4792238cb261a22
https://ora.ox.ac.uk/objects/uuid:5c8ba568-1038-4de4-b084-76a19ad80805
https://ora.ox.ac.uk/objects/uuid:5c8ba568-1038-4de4-b084-76a19ad80805
Publikováno v:
Arthritis & Rheumatism. 42:818-823
Publikováno v:
APMIS. 105:257-263
The role of the immune response in rheumatoid arthritis (RA) is a subject of debate, although it is widely believed to be a T-cell-driven disease. Progress is being hindered by lack of convincing evidence of a defined specific antigen initiating or p
Publikováno v:
British Medical Bulletin. 51:368-384
In chronic inflammatory diseases, typified by rheumatoid arthritis, we speculated that upregulation and/or disregulation of cytokine production in inflamed tissue might contribute both directly and/or indirectly to the pathology in the synovial joint
Publikováno v:
Rheumatology. 34:831-837
Thirty-four patients (24 females and 10 males) selected from 300 consecutive patients with established systemic sclerosis (SSc), with a current or past history of articular symptoms, were clinically documented and further studied using thermography a
Publikováno v:
Clinical and Experimental Immunology. 92:73-76
SUMMARY Following reports of associations between autoantibodies and living in the tropics, we have studied the seroprevalence and nature of anti-nuclear antibodies, anti-cardiolipin antibodies, antibodies to extractable nuclear antigens and anti-neu