Výsledky vyhledávání - "R N, Kolesnick"

Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis

Autor: Seamus J. Martin, Douglas R. Green, David M. Farschon, S. Mathias, John C. Reed, Hong Gang Wang, R. N. Kolesnick, Donald D. Newmeyer

Publikováno v: Scopus-Elsevier

Cell-free systems are valuable tools for the dissection of complex cellular processes. Here we show that cytoplasmic extracts from cells exposed to anti-Fas antibody or UV radiation contain an activity capable of reproducing morphological changes typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffbc3730e8f0d899ea6fe66d5d4b8f0
https://doi.org/10.1002/j.1460-2075.1995.tb00203.x

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Realizing the promise of apoptosis-based therapies: separating the living from the clinically undead

Autor: J L Tilly, R N Kolesnick

Publikováno v: Cell Death & Differentiation. 10:493-495

Realizing the promise of apoptosis-based therapies: separating the living from the clinically undead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cac376f989d8a2b1685054c91e19f75c
https://doi.org/10.1038/sj.cdd.4401217

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Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells

Autor: J L Browning, W D Jarvis, Frank A. Fornari, Steven Grant, David A. Gewirtz, R N Kolesnick

Publikováno v: Journal of Biological Chemistry. 269:31685-31692

Prior studies demonstrated that increased intracellular availability of ceramide induces apoptotic DNA degradation and cell death in the human leukemia cell lines HL-60 and U937 (Jarvis, W. D., Kolesnick, R. N., Fornari, F. A., Traylor, R. S., Gewirt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::572e93396e961cbd9408fc34f12064e6
https://doi.org/10.1016/s0021-9258(18)31750-2

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Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor signaling for human immunodeficiency virus production in chronically infected HL-60 cells

Autor: C I, Rivas, D W, Golde, J C, Vera, R N, Kolesnick

Publikováno v: Blood. 83:2191-2197

Tumor necrosis factor (TNF) is a potent inducer of human immunodeficiency virus (HIV) proviral transcription and subsequent mature virus production. Recent investigations have shown that TNF can use a signal transduction pathway in HL-60 cells involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf33d50ee5fb10311819f8db1b875ca1
https://doi.org/10.1182/blood.v83.8.2191.bloodjournal8382191

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Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency

Autor: L A, Peña, Z, Fuks, R N, Kolesnick

Publikováno v: Cancer research. 60(2)

Injury to the central nervous system (CNS) by ionizing radiation may be a consequence of damage to the vascular endothelium. Recent studies showed that radiation-induced apoptosis of endothelial cells in vitro and in the lung in vivo is mediated by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf7cb26533341b59ea6c9a2b68b1e82a
https://pubmed.ncbi.nlm.nih.gov/10667583

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Fas-mediated apoptosis and sphingomyelinase signal transduction: the role of ceramide as a second messenger for apoptosis

Autor: E W, Skowronski, R N, Kolesnick, D R, Green

Publikováno v: Cell death and differentiation. 3(2)

In this article, we review the role of sphingomyelinases and ceramide in the Fas-mediated apoptosis signal transduction cascade. Several stimuli, including ligation of Fas, have been shown to enhance either neutral and/or acidic sphingomyelinase acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e56b111b72cbcb1a35c9f9fc1663122d
https://pubmed.ncbi.nlm.nih.gov/17180079

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Ceramide and the induction of apoptosis

Autor: W D, Jarvis, S, Grant, R N, Kolesnick

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 2(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe10eadfbdb0f3f2c4b63331adf21ad3
https://pubmed.ncbi.nlm.nih.gov/9816082

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