Zobrazeno 1 - 10
of 15
pro vyhledávání: '"R N, Hines"'
Autor:
R N, Hines, Z, Luo, T, Cresteil, X, Ding, R A, Prough, J L, Fitzpatrick, S L, Ripp, K C, Falkner, N L, Ge, A, Levine, C J, Elferink
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
It is widely recognized that xenobiotic-metabolizing enzymes play a fundamental role in the basic processes of carcinogenesis and toxicity on one hand, and chemoprevention and drug efficacy on the other. Realization that different factors can profoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::708de786bba940287f80ea3e087013b5
https://pubmed.ncbi.nlm.nih.gov/11302926
https://pubmed.ncbi.nlm.nih.gov/11302926
Publikováno v:
Biochemical pharmacology. 61(4)
Carbaryl and thiabendazole, two widely used pesticides, have been shown to induce cytochrome P450 1A1 (CYP1A1) expression, but neither compound is capable of displacing [3H] 2,3,7,8-tetrachlorodibenzo-P-dioxin from its aryl hydrocarbon receptor bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3eae4be6b4013f42464c33d575e1ef6
https://pubmed.ncbi.nlm.nih.gov/11226373
https://pubmed.ncbi.nlm.nih.gov/11226373
Publikováno v:
Molecular and cellular biochemistry. 205(1-2)
We used Northern analyses, RNase protection assays and immunoblot analyses to examine the relationship among developmental age of the heart, abundance of mRNA and L-type calcium channel alpha1C subunit protein, and to establish the size of the native
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8477f89e3b1547f589894c13274ba35
https://pubmed.ncbi.nlm.nih.gov/10821427
https://pubmed.ncbi.nlm.nih.gov/10821427
Publikováno v:
Journal of biochemical and molecular toxicology. 13(3-4)
Mammalian flavin-containing monooxygenase functions in the oxygenation of numerous xenobiotics containing a soft nucleophile, usually a nitrogen or sulfur. A total of five distinct flavin monooxygenase (FMO) isoforms are expressed in mammals. Individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9322ad2e0ece6907cbf0f36641f456b
https://pubmed.ncbi.nlm.nih.gov/10098904
https://pubmed.ncbi.nlm.nih.gov/10098904
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(8)
Previous studies demonstrated that the flavin-containing monooxygenases (FMO) are expressed in a tissue-specific manner. To begin an elucidation of mechanisms regulating this expression pattern, genomic clones for rabbit FMO2 were isolated and charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39a1cb39606592e52b261d8a0e4d776c
https://pubmed.ncbi.nlm.nih.gov/8869825
https://pubmed.ncbi.nlm.nih.gov/8869825
Publikováno v:
Journal of Pediatric Gastroenterology and Nutrition. 39:S34-S35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9006b12627a47b2c45879ff7c04dbee1
https://doi.org/10.1097/00005176-200406001-00073
https://doi.org/10.1097/00005176-200406001-00073
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 272(3)
The microsomal flavin-containing monooxygenases (FMO) represent a family of xenobiotic-metabolizing enzymes with distinct tissue- and species-specific patterns of expression. Expression for two FMO isoforms (FMO1 and FMO2) in rabbit was characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::352ec2784449ae16b2360261aca6e973
https://pubmed.ncbi.nlm.nih.gov/7891346
https://pubmed.ncbi.nlm.nih.gov/7891346
Autor:
P D, Boucher, R N, Hines
Publikováno v:
Carcinogenesis. 16(2)
In previous studies, we identified a 21 bp palindrome (-794 to -774) located within the negative regulatory element of the human CYP1A1 gene consisting of an 8 bp inverted repeat and 5 bp spacer. This element specifically binds protein(s) present in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4283d9e3854aaa5ebe3a5d1f466fb268
https://pubmed.ncbi.nlm.nih.gov/7859371
https://pubmed.ncbi.nlm.nih.gov/7859371
Autor:
M P, Piechocki, R N, Hines
Publikováno v:
BioTechniques. 16(4)
We have optimized conditions for the successful execution of site-directed mutagenesis (SDM) in systems that utilize mutagenic oligonucleotide primers to direct the synthesis of mutant plasmids. In this report, we describe strategies for the design o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2953a6644d9769e9ff037585ef4d4aef
https://pubmed.ncbi.nlm.nih.gov/8024793
https://pubmed.ncbi.nlm.nih.gov/8024793
Publikováno v:
The Journal of biological chemistry. 268(23)
Employing reporter gene/CYP1A1 chimeric plasmids, we previously identified a 275-base pair (bp) cis-element (-833 to -558; NRE275) that down-regulated the CYP1A1 promoter. In the present study, this negative regulatory activity was further localized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::830249f6ba0853bcc59d000c999b1282
https://pubmed.ncbi.nlm.nih.gov/8349622
https://pubmed.ncbi.nlm.nih.gov/8349622