Discovery of ¹⁸ F Labeled AZD5213 Derivatives as Novel Positron Emission Tomography (PET) Radioligands Targeting Histamine Subtype-3 Receptor.

Autor: Song Z; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Li Y; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Dahl K; PET Science Centre, Precision Medicine and Biosamples, Oncology R&D, AstraZeneca, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden., Chaudhary A; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Sun Z; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA., Zhou X; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Chen J; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Gao Y; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Rong J; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Zhao C; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Patel JS; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA.; Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA., Collier L; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Ran C; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA., Zhai C; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Zhang L; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Haider A; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA., Mühlfenzl KS; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Pharmaceuticals, Gothenburg, 43183, Sweden., Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA., Elmore CS; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Pharmaceuticals, Gothenburg, 43183, Sweden., Schou M; PET Science Centre, Precision Medicine and Biosamples, Oncology R&D, AstraZeneca, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden., Liang SH; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, USA.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Sep 20, pp. e202400655. Date of Electronic Publication: 2024 Sep 20.

Unexpectedly high affinity of a novel histamine H(3) receptor antagonist, GSK239512, in vivo in human brain, determined using PET

Autor: S, Ashworth, A, Berges, E A, Rabiner, A A, Wilson, R A, Comley, R Y K, Lai, R, Boardley, G, Searle, R N, Gunn, M, Laruelle, V J, Cunningham

Publikováno v: British journal of pharmacology. 171(5)

This study aimed to investigate the relationship between the plasma concentration (PK) of the novel histamine H3 receptor antagonist, GSK239512, and the brain occupancy of H(3) receptors (RO) in healthy human volunteers.PET scans were obtained after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::357181e96ea9e00132b6eca411951678
https://pubmed.ncbi.nlm.nih.gov/24670146

Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195

Autor: S, Pappata, M, Levasseur, R N, Gunn, R, Myers, C, Crouzel, A, Syrota, T, Jones, G W, Kreutzberg, R B, Banati

Publikováno v: Neurology. 55(7)

Using quantitative PET, the authors studied the binding of [11C]PK11195, a marker of activated microglia, in the thalamus of patients with chronic middle cerebral artery infarcts. All patients showed increased [11C]PK11195 binding in the ipsilateral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d97cfb76e2605555da7a9d9645384ff
https://pubmed.ncbi.nlm.nih.gov/11061271

Synchronous measurements of prefrontal activity and pulse rate variability during online video game playing with functional near-infrared spectroscopy.

Autor: Zhang, Xuzhe^1,2 (AUTHOR), Long, Kehong^1,2 (AUTHOR), Wang, Ningxin¹ (AUTHOR), Zhang, Jin^1,2 (AUTHOR), Lei, Hao^1,2,3 (AUTHOR) leihao@wipm.ac.cn

Publikováno v: Journal of Innovative Optical Health Sciences. Nov2023, Vol. 16 Issue 6, p1-15. 15p.

Implications of Changes in GAAP for Business Combinations (and Goodwill) on Accounting and Finance Research.

Autor: Chaney, Paul K.¹, Gunn, Rita Nevada¹, Jeter, Debra Coleman²

Publikováno v: International Journal of Accounting (World Scientific). Jun2020, Vol. 55 Issue 2, p1-49. 49p.