Zobrazeno 1 - 10
of 24
pro vyhledávání: '"R N, Cahill"'
Publikováno v:
European journal of immunology. 31(3)
A diverse repertoire among peripheral T cells is established in early life by thymic export when the naive T cell pool is first formed. In contrast, during adult life the thymus has been thought to play only a minor role in T cell homeostasis. As ind
Publikováno v:
Immunology. 98(3)
We have studied the appearance and phenotype of recent thymic emigrants in blood, spleen and lymph nodes (LN) of neonatal lambs. Using in situ labelling of thymocytes with fluoroscein isothiocyanate (FITC), we examined the expression of the LN homing
Publikováno v:
International immunology. 7(10)
Current models of T cell migration place severe restrictions on the recirculation of virgin T cells, condemning them to migrate exclusively via high endothelial venules in lymph nodes until they either die or acquire the capacity to migrate to skin a
Publikováno v:
European journal of immunology. 25(3)
Current models of lymphocyte traffic suggest that homing specificities of T cells to tissues such as skin are generated outside the thymus as a result of activation of naive T cells by antigen in lymph nodes. Virgin T cells are thought to home to hig
Publikováno v:
International immunology. 6(12)
Tissue-selective streaming of T cells is considered to be a critical element in the integration of normal immune responses in intact animals. The results presented in this paper show that while there were major subsets of gut-homing T cells present i
Publikováno v:
European journal of immunology. 24(10)
The thymus plays an essential role in the generation and selection of T cells and exports approximately 0.5-1% of thymocytes per day in young animals and considerably fewer in older animals. To date there have been no studies directly examining fetal
Publikováno v:
European journal of immunology. 24(5)
We have used the technique of in situ intrathymic injection of fluorescein isothiocyanate to examine L-selectin expression on gamma delta and alpha beta T cells immediately after emigrating from the thymus of fetal and postnatal animals. We found tha
Publikováno v:
European journal of immunology. 24(1)
We have compared the expression of CD45RA on alpha beta and gamma delta T cells emigrating from the fetal and postnatal thymus. The fetal and postnatal thymus export both CD45RA+ and CD45RA- T cells. The number of gamma delta +CD45RA+ T cells was rem
Publikováno v:
Developmental and comparative immunology. 16(6)
We have examined the distribution of alpha beta and gamma delta T cells, together with B cells, in a range of lymph nodes and blood before and after birth. The proportions of blood-borne alpha beta and gamma delta T cells changed markedly during deve
Publikováno v:
Immunology. 72(2)
Tissue-specific and lymphocyte subset-specific lymphocyte recirculation patterns have been analysed simultaneously. Lymphocytes obtained from one lymph compartment were directly labelled with fluorochrome in vitro and returned to the blood of the sam