Zobrazeno 1 - 10
of 37
pro vyhledávání: '"R N, Batra"'
Autor:
Andrew R. Green, Samuel Aparicio, Stephen John Sammut, Alejandra Bruna, H. Raza Ali, Christopher E. Mason, Elena Provenzano, Ari Melnick, Arnie Purushotham, Suet-Feung Chin, Francine E. Garrett-Bakelman, Carlos Caldas, Aviezer Lifshitz, Amos Tanay, Leigh C. Murphy, Ankita Sati-Batra, Ana Tufegdzic Vidakovic, R N Batra, Ian O. Ellis, A. Dariush, Oscar M. Rueda
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Funder: Cancer Research UK
Funder: Wellcome Trust
DNA methylation is aberrant in cancer, but the dynamics, regulatory role and clinical implications of such epigenetic changes are still poorly understood. Here, reduced representation bisulf
Funder: Wellcome Trust
DNA methylation is aberrant in cancer, but the dynamics, regulatory role and clinical implications of such epigenetic changes are still poorly understood. Here, reduced representation bisulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbbd633e026ec06dd7cd63ac01e638c
Autor:
Maik Dahlhoff, Sacha Lebon, Diana Drago-Garcia, Carlos Caldas, Ilaria Marrocco, R N Batra, Yosef Yarden, Inpyo Choi, Mary Luz Uribe, Yasuo Tsutsumi, Oscar M. Rueda, Yuya Haga, Soma Ghosh, Itay Vaknin, Arunachalam Sekar, Lior Kramarski, Nishanth Belugali Nataraj
Publikováno v:
Sci Signal
Science Signaling
Science Signaling
Unlike early transcriptional responses to mitogens, later events are less well-characterized. Here, we identified delayed down-regulated genes (DDGs) in mammary cells after prolonged treatment with epidermal growth factor (EGF). The expression of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876a7c7ce6befe49aca0d8ead6a7f2c0
https://doi.org/10.1126/scisignal.abe6156
https://doi.org/10.1126/scisignal.abe6156
Autor:
Cristina Rueda, Andrew R. Green, Arnie Purushotham, Ali Hr, P. Pharoah, Bernard Pereira, Maurizio Callari, Leigh C. Murphy, Michelle Parisien, Christina Curtis, Carlos Caldas, Alejandra Bruna, S.J. Sammut, Joan Seoane, C. Gillett, Oscar M. Rueda, Samuel Aparicio, B Liu, Steven McKinney, R N Batra, S-F Chin, Ian O. Ellis, Jennifer L. Caswell-Jin, Elena Provenzano
Publikováno v:
Cancer Research. 79:GS3-06
Background: Recent studies have demonstrated that women with early stage ER-positive (ER+) and HER2-negative (HER2-) breast cancer have a persistent risk of recurrence and cancer related death up to 20 years post diagnosis, highlighting the chronic n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef54b3996658d70c105a703631e4b5d5
https://doi.org/10.1158/1538-7445.sabcs18-gs3-06
https://doi.org/10.1158/1538-7445.sabcs18-gs3-06
Autor:
R N Batra, Pavlo Lutsik, Clarissa Feuerstein-Akgoz, Maximilian Schönung, Daniel B. Lipka, Rocio Sotillo, Reka Toth, Joschka Hey, Kristin Köhler, Christoph Plass, Anand Mayakonda
Publikováno v:
Bioinformatics (Oxford, England).
Motivation Whole-genome bisulfite sequencing (WGBS) measures DNA methylation at base pair resolution resulting in large bedGraph like coverage files. Current options for processing such files are hindered by discrepancies in file format specification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d30db8204574458c6b63f237e947f5
https://pubmed.ncbi.nlm.nih.gov/33346800
https://pubmed.ncbi.nlm.nih.gov/33346800
Autor:
Cristina Rueda, Samuel Aparicio, R N Batra, Ian O. Ellis, Jennifer L. Caswell-Jin, Stephen John Sammut, Steven McKinney, Bin Liu, Bernard Pereira, Carlos Caldas, H. Raza Ali, Cheryl Gillett, Jose A. Seoane, Andrew R. Green, Paul D.P. Pharoah, Christina Curtis, Michelle Parisien, Maurizio Callari, Oscar M. Rueda, Elena Provenzano, Suet-Feung Chin, Arnie Purushotham, Alejandra Bruna, Leigh C. Murphy
Publikováno v:
Rueda, O M, Sammut, S-J, Seoane, J A, Chin, S-F, Caswell-Jin, J L, Callari, M, Batra, R, Pereira, B, Bruna, A, Ali, H R, Provenzano, E, Liu, B, Parisien, M, Gillett, C, McKinney, S, Green, A R, Murphy, L, Purushotham, A, Ellis, I O, Pharoah, P D, Rueda, C, Aparicio, S, Caldas, C & Curtis, C 2019, ' Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups ', Nature, vol. 567, no. 7748, pp. 399-404 . https://doi.org/10.1038/s41586-019-1007-8
The rates and routes of lethal systemic spread in breast cancer are poorly understood owing to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data. Long-term follow-up is especially important for those with oes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52213215dfad550184192361265a3cc
https://www.repository.cam.ac.uk/handle/1810/289797
https://www.repository.cam.ac.uk/handle/1810/289797
Autor:
M T, Sanchez-Santos, C, Garriga, A, Judge, R N, Batra, A J, Price, A D, Liddle, M K, Javaid, C, Cooper, D W, Murray, N K, Arden
Publikováno v:
Scientific Reports
To develop and validate a clinical prediction model of patient-reported pain and function after undergoing total knee replacement (TKR). We used data of 1,649 patients from the Knee Arthroplasty Trial who received primary TKR across 34 centres in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dcff22884a297eb53b177b9333b1d3ee
https://pubmed.ncbi.nlm.nih.gov/29467465
https://pubmed.ncbi.nlm.nih.gov/29467465
Autor:
Dimitri Livitz, Stephen J. Chanock, K Kübler, Alexandre Orthwein, Rosa Karlic, Daniel Rosebrock, Michael S. Lawrence, Alan D. D'Andrea, Hui Shen, Todd R. Golub, Eric S. Lander, Nicholas J Haradhavala, Daniel A. Haber, Leif W. Ellisen, Jaegil Kim, William D. Foulkes, Grace Tiao, Peter W. Laird, Kent W. Mouw, Paz Polak, Lior Z. Braunstein, Carlos Caldas, Yosef E. Maruvka, Atanas Kamburov, Aviad Zick, Ignaty Leshchiner, R N Batra, Gad Getz
Publikováno v:
Nat Genet
Biallelic inactivation of BRCA1 or BRCA2 is associated with a pattern of genome-wide mutations known as signature 3. By analyzing [sim]1, 000 breast cancer samples, we confirmed this association and established that germline nonsense and frameshift v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce5f6867622a36ea92842ca61220e5b
https://www.bib.irb.hr/894084
https://www.bib.irb.hr/894084
Autor:
G Thomas, R N Batra, Muhammad Javaid, David J Beard, K Peter-Guenther, Andrew Judge, David W. Murray, Nigel K Arden, K Dreinhoefer, Richard E. Field, Paul Dieppe, Cyrus Cooper
Publikováno v:
Osteoarthritis and Cartilage. 22(3):431-439
Summary Objectives To describe whether body mass index (BMI) is a clinically meaningful predictor of patient reported outcomes following primary total hip replacement (THR) surgery. Design Combined data from prospective cohort studies. We obtained in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09955bc99270eb585001f61e1d3957e8
Autor:
Nigel K Arden, Stephen Gwilym, Deborah J. Hart, Tim D. Spector, Cyrus Cooper, Irene Tracey, R N Batra, Muhammad Javaid, Anushka Soni
Publikováno v:
Arthritis & Rheumatism. 65:1942-1949
Objective Quantitative sensory testing (QST) and questionnaire-based assessments have been used to demonstrate features of neuropathic pain in subjects with musculoskeletal pain. However, their direct relationship has not been investigated in the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed188ed02a8497c8a5e90ad277cf0d0b
https://doi.org/10.1002/art.37962
https://doi.org/10.1002/art.37962
Autor:
G Thomas, R N Batra, T.C.B. Pollard, Harinderjit Gill, Andrew Judge, Bridget Watkins, Nigel K Arden, Eugene McNally, Sion Glyn-Jones, Andrew Carr
Publikováno v:
Pollard, T C B, Batra, R N, Judge, A, Watkins, B, McNally, E G, Gill, H S, Thomas, G E R, Glyn-Jones, S, Arden, N K & Carr, A J 2013, ' The hereditary predisposition to hip osteoarthritis and its association with abnormal joint morphology ', Osteoarthritis and Cartilage, vol. 21, no. 2, pp. 314-321 . https://doi.org/10.1016/j.joca.2012.10.015
Objective:Genetic factors and abnormalities of joint morphology are important in the aetiology of hip osteoarthritis (OA). The extent to which genetic influences are manifest through joint morphology has undergone limited investigation. Using a cohor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd74e306dc43ff886a5b901390df4e7
https://doi.org/10.1016/j.joca.2012.10.015
https://doi.org/10.1016/j.joca.2012.10.015