Zobrazeno 1 - 10
of 396
pro vyhledávání: '"R McDonnell"'
Autor:
W. Nie, S. V. Kumar, K. R. Arsenault, C. D. Peters-Lidard, I. E. Mladenova, K. Bergaoui, A. Hazra, B. F. Zaitchik, S. P. Mahanama, R. McDonnell, D. M. Mocko, M. Navari
Publikováno v:
Hydrology and Earth System Sciences, Vol 26, Pp 2365-2386 (2022)
The Middle East and North Africa (MENA) region has experienced more frequent and severe drought events in recent decades, leading to increasingly pressing concerns over already strained food and water security. An effective drought monitoring and ear
Externí odkaz:
https://doaj.org/article/f1b772053b834cfa955fe9c7db9ee32d
Autor:
Rohan Willis, Thomas C. R. McDonnell, Charis Pericleous, Emilio B. Gonzalez, Alvaro Schleh, Zurina Romay-Penabad, Ian P. Giles, Anisur Rahman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antiphospholipid syndrome (APS) is an autoimmune disorder in which autoantibodies cause clinical effects of vascular thrombosis and pregnancy morbidity. The only evidence-based treatments are anticoagulant medications such as warfarin and heparin. Th
Externí odkaz:
https://doaj.org/article/b1d23db02f4044e2816293b90112e7f5
Autor:
Diane M. Bunce, Maria J. Schroeder, Dianne J. Luning Prak, Melonie A. Teichert, Debra K. Dillner, Lauren R. McDonnell, Daniel P. Midgette, Regis Komperda
Publikováno v:
Journal of Chemical Education. 100:1751-1762
Autor:
Felix Nagel, Gottfried J. Palm, Norman Geist, Thomas C. R. McDonnell, Anne Susemihl, Britta Girbardt, Julia Mayerle, Markus M. Lerch, Michael Lammers, Mihaela Delcea
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3468 (2022)
(1) The serine protease inhibitor Kazal type 1 (SPINK1) inhibits trypsin activity in zymogen granules of pancreatic acinar cells. Several mutations in the SPINK1 gene are associated with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP
Externí odkaz:
https://doaj.org/article/3c82563708ff44a7a15a089819e1cb80
Autor:
Meredyth G Ll Wilkinson, Dale Moulding, Thomas C R McDonnell, Michael Orford, Chris Wincup, Joanna Y J Ting, Georg W Otto, Restuadi Restuadi, Daniel Kelberman, Charalampia Papadopoulou, Sergi Castellano, Simon Eaton, Claire T Deakin, Elizabeth C Rosser, Lucy R Wedderburn
Publikováno v:
Annals of the Rheumatic Diseases. 82:658-669
ObjectivesTo define the host mechanisms contributing to the pathological interferon (IFN) type 1 signature in Juvenile dermatomyositis (JDM).MethodsRNA-sequencing was performed on CD4+, CD8+, CD14+and CD19+cells sorted from pretreatment and on-treatm
Autor:
E. Zell, R. McDonnell
Publikováno v:
Computer Graphics Forum. 41:121-133
Autor:
James G. Christensen, Barbara Mroczkowski, Steven L. Bender, Gerrit Los, Mitchell D. Nambu, Pei-Pei Kung, Jingrong J. Cui, Gordon Alton, Tatiana B. Koudriakova, Shinji Yamazaki, Scott R. McDonnell, Maria E. Arango, Joseph H. Lee, Qiuhua Li, Helen Y. Zou
Supplementary Tables 1-2, Figures 1-3 from An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852bde0d087a4c3c60fe02218ead160a
https://doi.org/10.1158/0008-5472.22370280
https://doi.org/10.1158/0008-5472.22370280
Autor:
James G. Christensen, Barbara Mroczkowski, Steven L. Bender, Gerrit Los, Mitchell D. Nambu, Pei-Pei Kung, Jingrong J. Cui, Gordon Alton, Tatiana B. Koudriakova, Shinji Yamazaki, Scott R. McDonnell, Maria E. Arango, Joseph H. Lee, Qiuhua Li, Helen Y. Zou
The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), have been implicated in the progression of several human cancers and are attractive therapeutic targets. PF-2341066 was identified as a potent, orally bioavailable, AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d31a60f19801955af72b091c38b58ad
https://doi.org/10.1158/0008-5472.c.6496341
https://doi.org/10.1158/0008-5472.c.6496341
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Autor:
Thomas C. R. McDonnell, Rohan Willis, Charis Pericleous, Vera M. Ripoll, Ian P. Giles, David. A. Isenberg, Allan R. Brasier, Emilio B. Gonzalez, Elizabeth Papalardo, Zurina Romay-Penabad, Mohammad Jamaluddin, Yiannis Ioannou, Anisur Rahman
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
APS is an autoimmune disease in which antiphospholipid antibodies (aPL) cause vascular thrombosis and pregnancy morbidity. In patients with APS, aPL exert pathogenic actions by binding serum beta-2-glycoprotein I (β2GPI) via its N-terminal domain I
Externí odkaz:
https://doaj.org/article/5dbe595d033240e5b72049f6a3eda9b1