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Autor:
Carol A. Sattler, J Vaughan, R. McCague, Virgil Craig Jordan, Yvonne P. Dragan, Emile F. Nuwaysir, S. Fahey, Henry C. Pitot, Karlee L. Babcock
Publikováno v:
Carcinogenesis. 17:585-594
Long-term treatment of breast cancer patients with tamoxifen has prompted concern over potential toxicity of this drug with chronic administration. Since tamoxifen has estrogenic action in the rat liver and estrogenic agents can increase hepatoma inc
Publikováno v:
JNCI Journal of the National Cancer Institute. 85:806-812
Background The nonsteroidal anti-estrogen tamoxifen (TAM) is the front-line endocrine treatment for breast cancer, but disease recurrence is common. Treatment failure may occur because tumors become insensitive to TAM. Alternatively, resistance may o
Autor:
R. MCCAGUE
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 27
Autor:
S. J. C. Taylor, R. Mccague
Publikováno v:
ChemInform. 28
Autor:
B. E. Flowerdew, J. V. Barkley, M. P. Jackson, Stanley M. Roberts, Michael W. Cappi, S. Bergeron, Thomas C. Nugent, R. Mccague, B. M. Adger
Publikováno v:
ChemInform. 29
Autor:
R. McCague, Wilfried M. A. Niessen, C. E. M. Heeremans, R.A.M. van der Hoeven, J. van der Greef, G.K. Poon, M. Jarman, J.H. Davies
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 576:235-244
Liquid chromatography with thermospray mass spectrometry has proved to be an invaluable technique for the study of metabolic degradation of xenobiotics in complex biological fluids. This paper describes the detection of 4-hydroxyandrost-4-ene-3,17-di
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 572:143-157
The identification of metabolites from the pyridylglutarimide 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (PG, Rogletimide) was achieved using liquid chromatography-mass spectrometry with a thermospray interface (LC-TSP-MS). The urinary metabolites inc
Autor:
R C, Coombes, B P, Haynes, M, Dowsett, M, Quigley, J, English, I R, Judson, L J, Griggs, G A, Potter, R, McCague, M, Jarman
Publikováno v:
Cancer research. 55(5)
Idoxifene, a novel antiestrogen with reduced estrogenic activity when compared to tamoxifen, has been given to 20 women with metastatic breast cancer, 19 of whom had received tamoxifen previously, in doses between 10-60 mg. Idoxifene had an initial h