Zobrazeno 1 - 10
of 196
pro vyhledávání: '"R McAlpine"'
Autor:
Nalin Kataria, Chloe-Anne Martinez, Bernadette Kerr, Samantha S. Zaiter, Monica Morgan, Shelli R. McAlpine, Kristina M. Cook
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 3, Pp 480-495 (2019)
Externí odkaz:
https://doaj.org/article/08cc13b86d8f465b8d621a35672ff588
Autor:
Yuantao Huo, Laura K. Buckton, Jack L. Bennett, Eloise C. Smith, Frances L. Byrne, Kyle L. Hoehn, Marwa N. Rahimi, Shelli R. McAlpine
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 728-739 (2019)
The most challenging issue facing peptide drug development is producing a molecule with optimal physical properties while maintaining target binding affinity. Masking peptides with protecting groups that can be removed inside the cell, produces a cel
Externí odkaz:
https://doaj.org/article/6788bb62f2ca40478336fde2257a8a2c
Autor:
Jessica Kho, Suhyeon Kwon, Heath Ecroyd, P Chi Pham, Huixin Wang, Shelli R McAlpine, Alana Y Huang, W Alexander Donald, Joel P Rivers
Publikováno v:
ACS Med Chem Lett
[Image: see text] We report the first small molecule peptides based on the N-terminal sequence of heat shock protein 27 (Hsp27, gene HSPB1) that demonstrates chaperone-like activity. The peptide, comprising the SWDPF sequence located at Hsp27’s ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09a41c52f679fa3069245c265df54d1
https://doi.org/10.1021/acsmedchemlett.0c00609
https://doi.org/10.1021/acsmedchemlett.0c00609
Autor:
Shelli R. McAlpine, Seong Jong Kim
Publikováno v:
Molecules, Vol 18, Iss 1, Pp 1111-1121 (2013)
Comparing a solution phase route to a solid phase route in the synthesis of the cytotoxic natural product urukthapelstatin A (Ustat A) confirmed that a solid phase method is superior. The solution phase approach was tedious and involved cyclization o
Externí odkaz:
https://doaj.org/article/7398f69fc50843439a41bb6a7f850169
Publikováno v:
Chemistry – A European Journal. 27:1487-1513
Developing macrocyclic peptides that can reach intracellular targets is a significant challenge. This review discusses the most recent strategies used to develop cell permeable cyclic peptides that maintain binding to their biological target inside t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2933e3ba0e7fa9c8e5587565515f9b
https://doi.org/10.1002/chem.201905385
https://doi.org/10.1002/chem.201905385
Autor:
Robert Chapman, Shelli R. McAlpine, Shegufta N. Farazi, Raelene Boquiren, Henry Foster, Fan Chen
Publikováno v:
Polymer Chemistry. 11:425-432
Nanogels are attractive delivery vehicles for small hydrophilic cargo, such as peptides, but there is a limited understanding of how the structure of both the nanogel and cargo affect the drug loading and release properties, particularly in biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55b508164919de61e3bf5c60d584b2b8
https://doi.org/10.1039/c9py01120j
https://doi.org/10.1039/c9py01120j
Autor:
Dominique L. Baillargeon, Pooya Moradian Zadeh, Hanan Benabdalla, Mackenzie C. R. McAlpine, Bethany C. Brydges
Publikováno v:
Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal. 3:1-5
This paper explores the ability of artificial intelligence (AI) to detect or interpret emotions from information provided in the form of text. The study utilizes surveys (profiles) of 10 participants receiving palliative care. The profiles are analyz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87068fc40cb480388531199e0936e01
https://doi.org/10.26685/urncst.158
https://doi.org/10.26685/urncst.158
Autor:
Samantha S. Zaiter, Nalin Kataria, Bernadette Kerr, Monica N Morgan, Shelli R. McAlpine, Chloe-Anne Martinez, Kristina M. Cook
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 3, Pp 480-495 (2019)
Background/aims Hypoxia Inducible Factor-1α (HIF-1α) is involved in cancer progression and is stabilized by the chaperone HSP90 (Heat Shock Protein 90), preventing degradation. Previously identified HSP90 inhibitors bind to the N-terminal pocket of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb9fc6aa72d8187904ae633e604ec52
https://www.cellphysiolbiochem.com/Articles/000152/
https://www.cellphysiolbiochem.com/Articles/000152/
Publikováno v:
Chemistry – A European Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::297797424fbd2cd1e5862836087e5ec4
https://doi.org/10.1002/chem.202180561
https://doi.org/10.1002/chem.202180561
Publikováno v:
RSC Med Chem
We present the first NMR study of the interaction between heat shock protein 90 (Hsp90) and amino (N)-terminal inhibitors 17-AAG, and AUY922, and carboxy (C)-terminal modulators SM253, and LB51. We show that the two ATP mimics, 17-AAG and AUY922, bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4859f937819fa9a63946725144820c76
https://pubmed.ncbi.nlm.nih.gov/33898992
https://pubmed.ncbi.nlm.nih.gov/33898992