Výsledky vyhledávání - "R Mark, Simpson"

Akademický článek

Tongue orthotopic xenografts to study fusion-negative rhabdomyosarcoma invasion and metastasis in live animals

Autor: Sarah M. Hammoudeh, Yeap Ng, Bih-Rong Wei, Thomas D. Madsen, Mukesh P. Yadav, R. Mark Simpson, Roberto Weigert, Paul A. Randazzo

Publikováno v: Cell Reports: Methods, Vol 4, Iss 7, Pp 100802- (2024)

Summary: PAX3/7 fusion-negative rhabdomyosarcoma (FN-RMS) is a childhood mesodermal lineage malignancy with a poor prognosis for metastatic or relapsed cases. Limited understanding of advanced FN-RMS is partially attributed to the absence of sequenti

Externí odkaz: https://doaj.org/article/de21190a5a7242a48483a45be5f5303c

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Akademický článek

Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

Autor: Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Simon Zhongyuan Tian, Andy D. Tran, Debasish Paul, Steven D. Cappell, Sandra Burkett, Huaitian Liu, Maxwell P. Lee, Michael J. Kruhlak, Jennifer E. Dwyer, R. Mark Simpson, Gordon L. Hager, Yijun Ruan, Kent W. Hunter

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)

The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and chro

Externí odkaz: https://doaj.org/article/53398503c4ff4121a84866fffaede387

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Akademický článek

Pharmacokinetics and tolerability of the dual TORC1/2 inhibitor sapanisertib in combination with the MEK inhibitor trametinib in dogs

Autor: Bih-Rong Wei, Cody J. Peer, William J. Richardson, Stephen M. Hewitt, William D. Figg, R. Mark Simpson

Publikováno v: Frontiers in Veterinary Science, Vol 9 (2022)

Activation of one or both the Ras/MAPK and PI3K/Akt/mTOR signal transduction pathways are known to mediate oncogenicity of several canine and human cancers, including mucosal melanomas. Reciprocal cross activation between the two pathways can be a so

Externí odkaz: https://doaj.org/article/b3aa62de85994eb88e051c19e87a5dbd

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Akademický článek

Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence.

Autor: Vanesa C Sanchez, Howard H Yang, Alayna Craig-Lucas, Wendy Dubois, Brandi L Carofino, Justin Lack, Jennifer E Dwyer, R Mark Simpson, Christophe Cataisson, Max P Lee, Ji Luo, Kent W Hunter, Stuart H Yuspa

Publikováno v: PLoS Genetics, Vol 18, Iss 6, p e1010271 (2022)

The TGF-β-regulated Chloride Intracellular Channel 4 (CLIC4) is an essential participant in the formation of breast cancer stroma. Here, we used data available from the TCGA and METABRIC datasets to show that CLIC4 expression was higher in breast ca

Externí odkaz: https://doaj.org/article/a8c9af69453d42e7a8a1e57bff679371

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Akademický článek

CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers the opportunity to develop novel strategies to supplement and improve current therapeutics.

Externí odkaz: https://doaj.org/article/2c2a00203bef4e89885342925d64134f

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Akademický článek

cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma

Autor: Yunlong He, Wentao Zhu, Min Hwa Shin, Joy Gary, Chengyu Liu, Wendy Dubois, Shelley B. Hoover, Shunlin Jiang, Eryney Marrogi, Beverly Mock, R. Mark Simpson, Jing Huang

Publikováno v: Stem Cell Reports, Vol 8, Iss 6, Pp 1630-1644 (2017)

Bone marrow-derived mesenchymal stem cells (BMSCs) are proposed as the cells of origin of several subtypes of osteosarcoma (OS). However, signals that direct BMSCs to form different subtypes of OS are unclear. Here we show that the default tumor type

Externí odkaz: https://doaj.org/article/cf90561569b445598bdb324e83a3f4a3

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