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pro vyhledávání: '"R Mantena"'
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Autor:
Brett D. Hollingshead, Anna K. Kopec, Yutian Zhan, Timothy P. LaBranche, John W. Davis, Kyle Hayes, Srinivasa R. Mantena, Andrew W. Harrington, Laurence O. Whiteley, Zachary S. Stewart, Andrew D. Burdick
Publikováno v:
Toxicologic Pathology. 48:994-1007
Fatty liver disease is a potential risk factor for drug-induced liver injury (DILI). Despite advances in nonclinical in vitro and in vivo models to assess liver injury during drug development, the pharmaceutical industry is still plagued by idiosyncr
Autor:
Denise Wilcox, Vasudha Sehgal, Daniel H. Albert, John K. Pratt, Keith F. McDaniel, Xin Lu, Chaohong Sun, Dachun Liu, Joshua P. Plotnik, Srinivasa R. Mantena, Emily J. Faivre, Lisa A. Hasvold, George S. Sheppard, Xiaoli Huang, Le Wang, Lance J Bigelow, Stacey Fossey, Steve D. Fidanze, Lloyd T. Lam, Chang H. Park, Sanjay C. Panchal, Warren M. Kati, John J. Nicolette, Richard J. Bellin, Gaurav Mehta, Xiaoyu Lin, Mai H. Bui, Lu Zhang, Paul Hessler, Maricel Torrent, Tamar Uziel, Saul H. Rosenberg, Yu Shen, Kenton L. Longenecker
Publikováno v:
Nature. 578:306-310
Proteins of the bromodomain and extra-terminal (BET) domain family are epigenetic readers that bind acetylated histones through their bromodomains to regulate gene transcription. Dual-bromodomain BET inhibitors (DbBi) that bind with similar affinitie
Publikováno v:
BULLETIN of L.N. Gumilyov Eurasian National University. Technical Science and Technology Series. 132:127-133
Autor:
Prathap Kumar S. Mahalingaiah, Rita Ciurlionis, Bhupinder Bawa, Michael J. Liguori, Terry R. Van Vleet, Binu K. Philip, Kenneth R. Durbin, Ronnie L. Yeager, Srinivasa R. Mantena, Brian P. Enright
Publikováno v:
Pharmacology & Therapeutics. 200:110-125
Antibody-drug conjugates (ADCs) are a promising therapeutic modality for oncology indications. The concept of an ADC platform is to increase the therapeutic index (TI) of chemotherapeutics through more selective delivery of cytotoxic agents to tumor
Publikováno v:
Proceedings of the Eighth Japan-U.S. Conference on Composite Materials ISBN: 9780367812720
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a04ce479929eb68b97a51d843107829
https://doi.org/10.1201/9780367812720-99
https://doi.org/10.1201/9780367812720-99
Publikováno v:
Open Journal of Composite Materials. :43-53
This paper focuses on the dynamic tensile response of glass-graphite/epoxy composites illustrating improvement in energy absorption through hybridization. The dynamic response and energy absorption characteristics of pultruded hybrid combinations of
Autor:
Scott W. Mittelstadt, Eric A. G. Blomme, Mufeng Hu, Srinivasa R. Mantena, Mohan S. Rao, Xin Huang, Terry R. Van Vleet, Rishi R Gupta, Michael J. Liguori
Publikováno v:
Frontiers in Big Data
Most small molecule drugs interact with unintended, often unknown, biological targets and these off-target interactions may lead to both preclinical and clinical toxic events. Undesired off-target interactions are often not detected using current dru
Autor:
Laurence O. Whiteley, Lori A. Reed, Sergei S. Makarov, John W. Davis, Andrew D. Burdick, Robert V. Stanton, Ming Zeng, James A. Warneke, Srinivasa R. Mantena, Alexander V. Medvedev, Simone Sciabola, Elena Martsen, Brett D. Hollingshead
Publikováno v:
Nucleic Acids Research
Fully phosphorothioate antisense oligonucleotides (ASOs) with locked nucleic acids (LNAs) improve target affinity, RNase H activation and stability. LNA modified ASOs can cause hepatotoxicity, and this risk is currently not fully understood. In vitro
Autor:
Srinivasa R. Mantena, Cynthia M. Rohde, Dean Messing, Sharon A. Sokolowski, John W. Davis, Michael I. Jesson, Karrie A. Brenneman, Shawn P. O'Neil, Lindsay Tomlinson, Christopher G. Leonard, Laurence O. Whiteley, Steven Bailey, Deborah C. Carraher, Walter F. Bobrowski, Zachary S. Stewart, Yutian Zhan, W. Mark Vogel, Kimberly M. Shevlin, Dale L. Morris, Hungyun Lin, Shashi K. Ramaiah, Lauren M. Gauthier
Publikováno v:
Toxicologic Pathology. 42:229-242
Pancreatic toxicity commonly affects the endocrine or exocrine pancreas. However, it can also occur at the endocrine–exocrine interface (EEI), where the capillary network of the islet merges with the capillaries of the surrounding acinar tissue, th