Zobrazeno 1 - 10
of 3 200
pro vyhledávání: '"R Mackenzie"'
Autor:
Hideyuki Takahashi, Sanaea Bhagwagar, Sarah H. Nies, Hongping Ye, Xianlin Han, Marius T. Chiasseu, Guilin Wang, Ian R. Mackenzie, Stephen M. Strittmatter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Comorbid proteinopathies are observed in many neurodegenerative disorders including Alzheimer’s disease (AD), increase with age, and influence clinical outcomes, yet the mechanisms remain ill-defined. Here, we show that reduction of progra
Externí odkaz:
https://doaj.org/article/2b805bded4424ad3b625c7336380db12
Autor:
Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D’Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R. Mackenzie, Rosa Rademakers, Neil A. Ranson, Sheena E. Radford, Frederic Rousseau, Joost Schymkowitz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Tauopathies encompass a group of neurodegenerative disorders characterised by diverse tau amyloid fibril structures. The persistence of polymorphism across tauopathies suggests that distinct pathological conditions dictate the adopted polymo
Externí odkaz:
https://doaj.org/article/f3710df2103c4621bd7f36ca9c11b864
Autor:
Emily W Paolillo, Kaitlin B Casaletto, Annie L Clark, Jack C Taylor, Hilary W Heuer, Amy B Wise, Sreya Dhanam, Mark Sanderson-Cimino, Rowan Saloner, Joel H Kramer, John Kornak, Walter Kremers, Leah Forsberg, Brian Appleby, Ece Bayram, Andrea Bozoki, Danielle Brushaber, R Ryan Darby, Gregory S Day, Bradford C Dickerson, Kimiko Domoto-Reilly, Fanny Elahi, Julie A Fields, Nupur Ghoshal, Neill Graff-Radford, Matthew G H Hall, Lawrence S Honig, Edward D Huey, Maria I Lapid, Irene Litvan, Ian R Mackenzie, Joseph C Masdeu, Mario F Mendez, Carly Mester, Toji Miyagawa, Georges Naasan, Belen Pascual, Peter Pressman, Eliana Marisa Ramos, Katherine P Rankin, Jessica Rexach, Julio C Rojas, Lawren VandeVrede, Bonnie Wong, Zbigniew K Wszolek, Bradley F Boeve, Howard J Rosen, Adam L Boxer, Adam M Staffaroni
Publikováno v:
JMIR Aging, Vol 7, p e52831 (2024)
BackgroundFrontotemporal lobar degeneration (FTLD) is a leading cause of dementia in individuals aged
Externí odkaz:
https://doaj.org/article/e3a85b9c842b435281a2a70b74fac8bf
Autor:
Aykut Aytulun, Laura Sophie Grannemann, Colin R. MacKenzie, Alexandros Dimitrakopoulos, Francesca Pessanha‐Schlegel, Daniel Kamp, Leonhard Schilbach
Publikováno v:
Clinical Case Reports, Vol 12, Iss 5, Pp n/a-n/a (2024)
Key Clinical Message Recurrent depression with psychotic features is an atypical presentation of neurosyphilis. This case emphasizes the polymorphic clinical presentation of neurosyphilis and how it mimics affective disorders with psychotic symptoms.
Externí odkaz:
https://doaj.org/article/59e1d9955a524493987746c27a93f769
Autor:
Beibei Zhao, Catherine M. Cowan, Juliane A. Coutts, Darren D. Christy, Ananya Saraph, Shawn C. C. Hsueh, Stephen S. Plotkin, Ian R. Mackenzie, Johanne M. Kaplan, Neil R. Cashman
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma/Translocated in Sarcoma (FUS) are ribonucleoproteins associated with pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Under physiologic
Externí odkaz:
https://doaj.org/article/1d6e11bc4ae24e4888e214787663cda9
Publikováno v:
Atmospheric Measurement Techniques, Vol 16, Pp 4885-4898 (2023)
Pollen are hygroscopic; therefore, they have the potential to act as cloud condensation nuclei (CCN) in the atmosphere. This could have uncertain implications for cloud processes and climate as well as plant biodiversity and human health. Previous st
Externí odkaz:
https://doaj.org/article/4ccbfdc338e54201a037b88d7e177723
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 1, Pp 22-34 (1996)
Cholesteryl ester transfer protein (CETP), a 476 amino acid glycoprotein, mediates cholesteryl ester (CE), triglyceride, and phospholipid transfer among plasma lipoproteins. A monoclonal antibody (mAb), TP2, specific for an epitope within the last 26
Externí odkaz:
https://doaj.org/article/d37b7419647c48c49e35928300e023bd
Autor:
R Raffai, R Maurice, K Weisgraber, T Innerarity, X Wang, R MacKenzie, T Hirama, D Watson, E Rassart, R Milne
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 9, Pp 1905-1918 (1995)
Apolipoprotein E (apoE), a 299 amino acid protein, is a ligand for the low density lipoprotein receptor (LDLr). It has been established that basic amino acids situated between apoE residues 136 and 150 participate in the interaction of apoE with the
Externí odkaz:
https://doaj.org/article/de81621fec99440b9a23cd4f77ce14e7
Publikováno v:
Veterinary Medicine and Science, Vol 10, Iss 1, Pp n/a-n/a (2024)
Abstract Background Anal sac adenocarcinoma (ASACA) in dogs is a malignant perianal tumour that often metastasizes to the iliosacral lymph nodes. Additionally, this tumour can be associated with hypercalcemia of malignancy. To date, no study has look
Externí odkaz:
https://doaj.org/article/d8ab30ee1f7c4847aa531efd463a02fd
Autor:
F. Thalasso, B. Riquelme, A. Gómez, R. Mackenzie, F. J. Aguirre, J. Hoyos-Santillan, R. Rozzi, A. Sepulveda-Jauregui
Publikováno v:
Biogeosciences, Vol 20, Pp 3737-3749 (2023)
We present a reliable and robust open dynamic chamber for measuring greenhouse gas exchange in peatlands with minimal disturbance of the ground. This chamber, called the “skirt chamber”, is based on a transparent plastic film placed above an open
Externí odkaz:
https://doaj.org/article/fdd925d2904b4bd389a2b9e5c9e678a6