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Hplc-nmr identification of the human urinary metabolites of (—)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV)

Autor: R. D. Farrant, John P. Shockcor, John C. Lindon, Paul N. Sanderson, L W Frick, R M Wurm, B. C. Sweatman

Publikováno v: Xenobiotica. 26:189-199

1. Human urine samples from a clinical trial of the anti-HIV compound (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-cyto sin e (BW524W91) have been analysed using 19F-nmr and 1H-hplc-nmr spectroscopy. 2. The identities and relative level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba19d36b483e35168cdb8f7486bbc55d
https://doi.org/10.3109/00498259609046699

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Transient pulmonary platelet sequestration during endotoxemia in dogs

Autor: F D, Gutmann, V S, Murthy, M T, Wojciechowski, R M, Wurm, R A, Edzards

Publikováno v: Circulatory shock. 21(3)

We evaluated the time-course of regional platelet sequestration, following a bolus dose of endotoxin in anesthetized dogs. Autologous indium 111 labeled platelets, representing less than 1% of the circulating platelets, were injected 35-60 min prior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b4781c5ab74a605e89149a132faf956
https://pubmed.ncbi.nlm.nih.gov/3105907

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