Výsledky vyhledávání - "R M Steinman"

Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity

Autor: C, Trumpfheller, M P, Longhi, M, Caskey, J, Idoyaga, L, Bozzacco, T, Keler, S J, Schlesinger, R M, Steinman

Publikováno v: Journal of internal medicine. 271(2)

Current vaccines primarily work by inducing protective antibodies. However, in many infections like HIV, malaria and tuberculosis as well as cancers, there remains a need for durable and protective T-cell immunity. Here, we summarize our efforts to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::468f2b3d71a27a1c09c6b16067c46cc2
https://pubmed.ncbi.nlm.nih.gov/22126373

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Dendritic cells: translating innate to adaptive immunity

Autor: R M, Steinman, H, Hemmi

Publikováno v: Current topics in microbiology and immunology. 311

The innate immune system provides many ways to quickly resist infection. The two best-studied defenses in dendritic cells (DCs) are the production of protective cytokines-like interleukin (IL)-12 and type I interferons-and the activation and expansio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::978498cdb6e23909b84bb3d8619b1f4c
https://pubmed.ncbi.nlm.nih.gov/17048704

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The dendritic cell advantage: New focus for immune-based therapies

Autor: R M Steinman

Publikováno v: Drug newsperspectives. 13(10)

Dendritic cells (DCs) provide a much earlier and antigen-specific means for manipulating the immune response. The best-studied function of DCs is to convert antigens into immunogens for T cells. The "DC advantage" entails a myriad of functions. DCs a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205931b133ac210b889bca994d94292b
https://pubmed.ncbi.nlm.nih.gov/12879129

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The interaction of immunodeficiency viruses with dendritic cells

Autor: R M, Steinman, A, Granelli-Piperno, M, Pope, C, Trumpfheller, R, Ignatius, G, Arrode, P, Racz, K, Tenner-Racz

Publikováno v: Current topics in microbiology and immunology. 276

Dendritic cells (DCs) can influence HIV-1 and SIV pathogenesis and protective mechanisms at several levels. First, HIV-1 productively infects select populations of DCs in culture, particularly immature DCs derived from blood monocytes and skin (Lange

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4095563721680bba60a1087a6aab6f4
https://pubmed.ncbi.nlm.nih.gov/12797441

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Dendritic cells: specialized and regulated antigen processing machines

Autor: I, Mellman, R M, Steinman

Publikováno v: Cell. 106(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0c561d2a543791ad0a17338af2883b1
https://pubmed.ncbi.nlm.nih.gov/11509173

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Presentation of SIVgag to monkey T cells using dendritic cells transfected with a recombinant adenovirus

Autor: L, Zhong, A, Granelli-Piperno, M, Pope, R, Ignatius, M G, Lewis, S S, Frankel, R M, Steinman

Publikováno v: European journal of immunology. 30(11)

To pursue the capacity of monkey dendritic cells (DC) to be modified by adenoviral vectors and present the encoded antigens, we generated DC from blood monocytes and infected them with recombinant adenoviruses encoding GFP reporter and SIVgag or nef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::60b2c346ae49830e0c519d5892e6deca
https://pubmed.ncbi.nlm.nih.gov/11093144

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The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells

Autor: R, Ignatius, Y, Wei, S, Beaulieu, A, Gettie, R M, Steinman, M, Pope, S, Mojsov

Publikováno v: AIDS research and human retroviruses. 16(11)

Dendritic cells (DCs) have been shown to be important in the replication of human and simian immunodeficiency viruses (HIV and SIV, respectively) in vivo and in vitro. DCs express CD4 and several chemokine receptors, such as CCR5 and CXCR4, which are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::913aebca5096df46e10cf84de1fc7bf1
https://pubmed.ncbi.nlm.nih.gov/10933620

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DC-SIGN: a guide to some mysteries of dendritic cells

Autor: R M, Steinman

Publikováno v: Cell. 100(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf9734ca2061c557fd23dee751daa17d
https://pubmed.ncbi.nlm.nih.gov/10721995

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Presentation of epstein-barr virus latency antigens to CD8(+), interferon-gamma-secreting, T lymphocytes

Autor: M, Subklewe, A, Chahroudi, K, Bickham, M, Larsson, M G, Kurilla, N, Bhardwaj, R M, Steinman

Publikováno v: European journal of immunology. 29(12)

Epstein-Barr virus (EBV) infects more than 95 % of the human population and causes an asymptomatic life-long infection in the majority of EBV carriers. Cell-mediated immunity provides resistance to EBV, as demonstrated by the occurrence of EBV-induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ee23b5cfe375599b835e4100d7a591d
https://pubmed.ncbi.nlm.nih.gov/10602009

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