Výsledky vyhledávání - "R M Ransohoff"

TREATMENT OF FULMINANT MULTIPLE SCLEROSIS WITH INTRAVENOUS CYCLOPHOSPHAMIDE

Autor: R. P. Kinkel, Jeffrey A. Cohen, R. A. Rudick, M. Namey, Kathleen M. Schwetz, Bianca Weinstock-Guttman, R. M. Ransohoff, D. Gogol

Publikováno v: The Neurologist. 3:178-185

BACKGROUNDThe role of intravenous (IV) cyclophosphamide (CTX) for patients with progressive multiple sclerosis (MS) remains controversial, despite numerous controlled and uncontrolled clinical trials.OBJECTIVETo present the results of open label trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c501c555434a8a75a001ea1cbf461de3
https://doi.org/10.1097/00127893-199705000-00005

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TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression

Autor: Y J Lee, Y Han, H T Lu, V Nguyen, H Qin, P H Howe, B A Hocevar, J M Boss, R M Ransohoff, E N Benveniste

Publikováno v: The Journal of Immunology. 158:2065-2075

Recently, a non-DNA binding protein, class II transactivator (CIITA), has been shown to be required for constitutive and IFN-gamma-inducible class II MHC transcription. The cytokine TGF-beta inhibits IFN-gamma-induced class II MHC expression at the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8069e94aab415e03a607938ea2367acd
https://doi.org/10.4049/jimmunol.158.5.2065

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Stimulus-specific inhibition of intracellular adhesion molecule-1 gene expression by TGF-beta

Autor: P Shrikant, S J Lee, I Kalvakolanu, R M Ransohoff, E N Benveniste

Publikováno v: The Journal of Immunology. 157:892-900

Astrocytes and microglia, the two major glial cells within the central nervous system, can function as immune effector cells upon activation. Intercellular adhesion molecule-1 (ICAM-1), a cell surface glycoprotein involved in extravasation into infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e992fd025e180742730ae87308c88dbe
https://doi.org/10.4049/jimmunol.157.2.892

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Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines

Autor: S J Rosenman, P Shrikant, L Dubb, E N Benveniste, R M Ransohoff

Publikováno v: The Journal of Immunology. 154:1888-1899

Astrocytes in the central nervous system (CNS) associate intimately with vascular endothelial cells and are integral to the blood-brain barrier (BBB). Leukocyte transmigration across the BBB is a cardinal feature of CNS inflammation, as observed in e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfd01bf8f9d4767d197bce1eb7373cc9
https://doi.org/10.4049/jimmunol.154.4.1888

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