Zobrazeno 1 - 10
of 71
pro vyhledávání: '"R M Philpot"'
Publikováno v:
Journal of Biological Chemistry. 269:17525-17530
Methionine was a substrate for cDNA-expressed rabbit flavin-containing monooxygenase (FMO) 1, FMO2, and FMO3, while incubations with membrane fractions containing cDNA-expressed FMO5 did not lead to the detection of methionine sulfoxide; Km values wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20300cf07b1ea080f799d85ea4498576
https://doi.org/10.1016/s0021-9258(17)32472-9
https://doi.org/10.1016/s0021-9258(17)32472-9
Publikováno v:
Toxicology and Applied Pharmacology. 123:193-198
Inhibition of pulmonary CYP4B1 activity by pretreatment of rats with p-xylene decreased the ability of lung microsomes to N-hydroxylate 2-aminofluorene and prevented the lung damage normally seen after dosing with ipomeanol. The toxicity of ipomeanol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb4f4c6b06bbb98704e368513fb869f
https://doi.org/10.1006/taap.1993.1237
https://doi.org/10.1006/taap.1993.1237
Publikováno v:
Journal of Biological Chemistry. 266:19681-19687
The complete primary structures of two distinct rabbit alpha-class glutathione S-transferase (GST) subunits, rbGST alpha I and rbGST alpha II, have been derived from cDNA sequences. Clones encoding rbGST alpha I were isolated from both hepatic and pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9c675994726ccb1ce1ef388c1a65484
https://doi.org/10.1016/s0021-9258(18)55046-8
https://doi.org/10.1016/s0021-9258(18)55046-8
Publikováno v:
Alcoholism, clinical and experimental research. 27(4)
Alcohol abuse levels are very high in adolescents, creating a significant societal issue. It has been shown that people who begin alcohol use as adolescents are more likely to become addicts than people who initiate alcohol use as adults. It is impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71b6ef7d762cfa1c2c6ee21f2c400e59
https://pubmed.ncbi.nlm.nih.gov/12711921
https://pubmed.ncbi.nlm.nih.gov/12711921
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(1)
Flavin-containing monooxygenase (FMO) 3 is the predominant FMO isoform in adult human liver; however, little is known about its expression in common laboratory species. Studies have shown FMO3 levels to be sex-dependent in mouse liver, but not in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a24e37d62b91f210be42364aa8ea4341
https://pubmed.ncbi.nlm.nih.gov/9884308
https://pubmed.ncbi.nlm.nih.gov/9884308
Autor:
J R, Halpert, T L, Domanski, O, Adali, C P, Biagini, J, Cosme, E A, Dierks, E F, Johnson, J P, Jones, P, Ortiz de Montellano, R M, Philpot, O, Sibbesen, W K, Wyatt, Z, Zheng
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(12)
This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f3f43f7c320a9586f1387fd6bbf8a6c
https://pubmed.ncbi.nlm.nih.gov/9860932
https://pubmed.ncbi.nlm.nih.gov/9860932
Autor:
D H, Lang, C K, Yeung, R M, Peter, C, Ibarra, R, Gasser, K, Itagaki, R M, Philpot, A E, Rettie
Publikováno v:
Biochemical pharmacology. 56(8)
In the present study, we expressed human flavin-containing monooxygenase 1 (FMO1), FMO3, FMO4t (truncated), and FMO5 in the baculovirus expression vector system at levels of 0.6 to 2.4 nmol FMO/mg of membrane protein. These four isoforms, as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::043025b3e034f400186213371752d25a
https://pubmed.ncbi.nlm.nih.gov/9776311
https://pubmed.ncbi.nlm.nih.gov/9776311
Publikováno v:
Journal of biochemical and molecular toxicology. 12(4)
Full-length cDNA clones encoding FMO1 and FMO5 have been isolated from a library constructed with mRNA from the liver of a female CD-1 mouse. The derived sequence of FMO1 contains 2310 bases: 1596 in the coding region, 301 in the 5'-flanking region,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d715d04e56ee80c97f383a34902a82da
https://pubmed.ncbi.nlm.nih.gov/9580872
https://pubmed.ncbi.nlm.nih.gov/9580872
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(7)
The baculovirus expression vector system was used to overexpress human FMO3 in insect cells for catalytic, structural, and immunochemical studies. Membranes prepared from infected Trichoplusia ni cell suspensions catalyzed NADPH-dependent metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e73f230098734cd00af0420d1661fb10
https://pubmed.ncbi.nlm.nih.gov/9224773
https://pubmed.ncbi.nlm.nih.gov/9224773
Publikováno v:
Molecular pharmacology. 51(3)
Rabbit liver microsomes catalyzed the highly stereoselective, NADPH- and time-dependent S-oxidation of S-benzyl-L-cysteine (SBC), S-allyl-L-cysteine (SAC), S-(1,2-dichlorovinyl)-L-cysteine (DCVC), and S-(1,2,2-trichlorovinyl)-L-cysteine (TCVC) to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9d42933af43576daff34814e005fa3d
https://pubmed.ncbi.nlm.nih.gov/9058607
https://pubmed.ncbi.nlm.nih.gov/9058607