Zobrazeno 1 - 10
of 53
pro vyhledávání: '"R M Perlmutter"'
Publikováno v:
The Journal of Experimental Medicine
The nonreceptor protein tyrosine kinase p56lck (Lck) serves as a fundamental regulator of thymocyte development by delivering signals from the pre-T cell receptor (pre-TCR) that permit subsequent maturation. However, considerable evidence supports th
Publikováno v:
The Journal of Immunology. 155:1286-1295
The lymphocyte-specific proto-oncogene lck is transcribed from two developmentally regulated, independently functioning promoters. The proximal promoter is used in thymocytes, but not in peripheral T lymphocytes. The distal promoter operates in all s
Autor:
S Dziennis, C M Blosch, Daniel G. Tenen, H. L. Pahl, R M Perlmutter, Thomas L. Rothstein, D L Morris, R A Van Etten
Publikováno v:
Blood. 85:319-329
CD11b is the alpha chain of the Mac-1 integrin and is preferentially expressed in myeloid cells (neutrophils, monocytes, and macrophages). We have previously shown that the CD11b promoter directs cell-type- specific expression in myeloid lines using
Publikováno v:
International Immunology. 7:1529-1533
Engagement of CD40 by its ligand induces transcription of unrearranged Ig heavy chain genes, an initial step in switch recombination. The following studies were undertaken to understand the molecular basis of this response. Co-culture of S19 cells ex
Autor:
S, Takaki, K, Sauer, B M, Iritani, S, Chien, Y, Ebihara, K, Tsuji, K, Takatsu, R M, Perlmutter
Publikováno v:
Immunity. 13(5)
Lnk is an SH2 domain-containing adaptor protein expressed preferentially in lymphocytes. To illuminate the importance of Lnk, we generated lnk(-/-) mice. Whereas T cell development was unaffected, pre-B and immature B cells accumulated in the spleens
Publikováno v:
Methods in enzymology. 327
Autor:
S D, Levin, R M, Koelling, S L, Friend, D E, Isaksen, S F, Ziegler, R M, Perlmutter, A G, Farr
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(2)
A novel cytokine from a thymic stromal cell line (thymic stromal lymphopoietin (TSLP)) promotes the development of B220+/IgM+ immature B cells when added to fetal liver cultures, long term bone marrow cultures, or bone marrow cells plated in semisoli
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(5)
The tyrosine kinase Jak3 plays a key role in transducing signals from the IL-2, -4, -7, -9, and -15 receptors. Mice lacking Jak3 exhibit a profound, early block in both B and T cell development. To examine the mechanisms whereby Jak3 influences T cel
Autor:
S, Takaki, J D, Watts, K A, Forbush, N T, Nguyen, J, Hayashi, J, Alberola-Ila, R, Aebersold, R M, Perlmutter
Publikováno v:
The Journal of biological chemistry. 272(23)
Stimulation of the T cell antigen receptor (TCR) activates a set of non-receptor protein tyrosine kinases that assist in delivering signals to the cell interior. Among the presumed substrates for these kinases, adaptor proteins, which juxtapose effec
Autor:
H J, Fehling, B M, Iritani, A, Krotkova, K A, Forbush, C, Laplace, R M, Perlmutter, H, von Boehmer
Publikováno v:
Immunity. 6(6)
Mice deficient for the pre-TCR alpha (pT alpha) chain cannot form a pre-T cell receptor (TCR) and exhibit a severe defect in early T cell development, characterized by lack of "beta selection" and impaired generation of double-positive (DP) thymocyte