Výsledky vyhledávání

Complete regression of human fibrosarcoma xenografts after local Newcastle disease virus therapy

Autor: R M, Lorence, B B, Katubig, K W, Reichard, H M, Reyes, A, Phuangsab, M D, Sassetti, R J, Walter, M E, Peeples

Publikováno v: Cancer research. 54(23)

We have recently demonstrated that a single local injection of the avian pathogen Newcastle disease virus (NDV; strain 73-T) causes complete regression of human neuroblastoma xenografts in athymic mice (R. M. Lorence, K. W. Reichard, B. B. Katubig, H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::477d98cb3f19543e798f4fade270f538
https://pubmed.ncbi.nlm.nih.gov/7954437

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A phase II trial of afatinib (BIBW 2992) in patients (pts) with advanced non-small cell lung cancer previously treated with erlotinib (E) or gefitinib (G)

Publikováno v: Journal of Clinical Oncology. 29:7524-7524

7524 Background: An unmet medical need exists in NSCLC pts after failure of E or G [reversible EGFR tyrosine kinase inhibitors (TKIs)], particularly in pts with T790M EGFR mutations, the most common mechanism of acquired resistance. Afatinib (A), an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c426d9231e54d0a9da60f9728226e2c
https://doi.org/10.1200/jco.2011.29.15_suppl.7524

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In vivo administration of recombinant growth hormone or gamma interferon activities macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with generation of reactive oxygen intermediates

Autor: Libby M. Yunger, Keith W. Kelley, Sean Arkins, Carl K. Edwards, Robert Dantzer, S.M. Ghiasuddin, R. M. Lorence

Publikováno v: Scopus-Elsevier
Infection and Immunity
Infection and Immunity, American Society for Microbiology, 1992, 60 (6), pp.2514-2521

Purified and recombinant forms of growth hormone (GH) as well as of recombinant rat gamma interferon (IFN-gamma) enhance the survival of rats deprived of endogenous pituitary GH secretion by hypophysectomy (HX rats) and infected with virulent Salmone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d918c20792be95194f7af09ef45a9de0
https://europepmc.org/articles/PMC257190/

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Newcastle Disease Virus as an Antineoplastic Agent: Induction of Tumor Necrosis Factor- and Augmentation of Its Cytotoxicity2

Autor: Keith W. Kelley, Pamela A. Rood, R. M. Lorence

Publikováno v: JNCI Journal of the National Cancer Institute. 80:1305-1312

The oncolytic strain 73-T of Newcastle disease virus (NDV) has been reported to be beneficial in the treatment of cancer patients, but little is known about its mechanism of action. In this study, NDV strain 73-T and a wild-type isolate of NDV were f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdbd1396bcf6d763e22f396169f170fe
https://doi.org/10.1093/jnci/80.16.1305

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Use of an azido-ubiquinone derivative to identify subunit I as the ubiquinol binding site of the cytochrome d terminal oxidase complex of Escherichia coli

Autor: Linda Yu, Fu-De Yang, R M Lorence, Chang-An Yu, R B Gennis

Publikováno v: Journal of Biological Chemistry. 261:14987-14990

The radiolabeled, photoreactive azido-ubiquinone derivative (azido-Q), 3-azido-2-methyl-5-methoxy-6-(3,7-dimethyl-[3H]octyl)- 1,4-benzoquinone, was used to investigate the active site of ubiquinol oxidase activity of the cytochrome d complex, a two-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75456fc8749cd4fec98480e107750605
https://doi.org/10.1016/s0021-9258(18)66817-6

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Trypsin proteolysis of the cytochrome d complex of Escherichia coli selectively inhibits ubiquinol oxidase activity while not affecting N,N,N',N'-tetramethyl-p-phenylenediamine oxidase activity

Autor: R. M. Lorence, K. Carter, H. R. Kaback, K. Matsushita, Robert B. Gennis

Publikováno v: Journal of Biological Chemistry. 263:5271-5276

The cytochrome d complex is one of two membrane-bound terminal oxidases of the Escherichia coli aerobic respiratory chain. Previous studies have shown that this enzyme reconstituted into proteoliposomes rapidly oxidizes ubiquinol-8 as well as the sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e34bae837cbc82ae655f06a7c401c15
https://doi.org/10.1016/s0021-9258(18)60711-2

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Respiratory proteins from the extremely thermophilic aerobic bacterium, Thermus thermophilus. Purification procedures for cytochromes c552, c555,549, and c1aa3 and chemical evidence for a single subunit cytochrome aa3

Autor: Karen L. Findling, James A. Fee, R. M. Lorence, George E. Tarr, Tatsuro Yoshida, M G Choc

Publikováno v: Journal of Biological Chemistry. 259:112-123

We have developed a chemically defined, minimal growth medium for Thermus thermophilus which is suitable for nutritional studies, isotopic enrichment, and genetic manipulation of the organism. Reliable procedures are described for the large scale pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::054feeb1b07336f6a9e068d64275dfba
https://doi.org/10.1016/s0021-9258(17)43629-5

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Specific overproduction and purification of the cytochrome b558 component of the cytochrome d complex from Escherichia coli

Autor: Robert B. Gennis, George N. Green, R. M. Lorence

Publikováno v: Biochemistry. 25:2309-2314

In Escherichia coli strain GR84N[pNG10], the cloned gene for subunit I of the membrane-bound cytochrome d complex resulted in the overproduction of cytochrome b558 and facilitated purification of this cytochrome. Extracting membranes with 1% Triton X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e230b164d877e143560dcdd8c99920
https://doi.org/10.1021/bi00357a002

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