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Prostaglandins mediate the effects of 1,25-(OH)2D3 and 24,25-(OH)2D3 on growth plate chondrocytes in a metabolite-specific and cell maturation-dependent manner

Autor: Barbara D. Boyan, Victor L. Sylvia, David D Dean, R. M. Gilley, Zvi Schwartz

Publikováno v: Bone. 24:475-484

Prior studies have shown that 1,25-(OH)2D3 stimulates alkaline phosphatase, phospholipase A2 (PLA2), and protein kinase C (PKC)-specific activities, and production of prostaglandin E2 (PGE2) in growth zone chondrocytes. In contrast, 24,25-(OH)2D3 sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31d27fc2c560adac304c4a91238c1d5
https://doi.org/10.1016/s8756-3282(99)00014-9

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The Effect of Prostaglandin E2on Costochondral Chondrocyte Differentiation Is Mediated by Cyclic Adenosine 3′,5′-Monophosphate and Protein Kinase C1

Autor: David D Dean, R. M. Gilley, Zvi Schwartz, Barbara D. Boyan, Victor L. Sylvia

Publikováno v: Endocrinology. 139:1825-1834

Recent studies indicate that vitamin D metabolites exert rapid effects on growth plate chondrocytes via changes in PG production and protein kinase C (PKC) activity. This suggests that these two products of vitamin D action may be interrelated. To te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a534b3c8b7147fa10daeaf4993e68450
https://doi.org/10.1210/endo.139.4.5919

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Biodegradable and biocompatible poly(DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies

Autor: J A Meulbroek, R M Gilley, J K Staas, T T R Tice, John H. Eldridge

Publikováno v: Infection and Immunity. 59:2978-2986

Microspheres composed of biocompatible, biodegradable poly(DL-lactide-co-glycolide) (DL-PLG) and staphylococcal enterotoxin B (SEB) toxoid were evaluated as a vaccine delivery system when subcutaneously injected into mice. As measured by circulating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd192611d979867295d0dc5f6067a53f
https://doi.org/10.1128/iai.59.9.2978-2986.1991

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The effect of prostaglandin E2 on costochondral chondrocyte differentiation is mediated by cyclic adenosine 3',5'-monophosphate and protein kinase C

Autor: Z, Schwartz, R M, Gilley, V L, Sylvia, D D, Dean, B D, Boyan

Publikováno v: Endocrinology. 139(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e08f3091875be820d9fe3e0606414f27
https://pubmed.ncbi.nlm.nih.gov/9528968

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New advances in vaccine delivery systems

Autor: J H, Eldridge, J K, Staas, D, Chen, P A, Marx, T R, Tice, R M, Gilley

Publikováno v: Seminars in hematology. 30(4 Suppl 4)

Successful application of the next generation of vaccines will require that protection be induced with a minimal number of administrations, and that a practical approach to inducing immunity at mucosal surfaces be developed. For these reasons, vaccin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a95a1e011eed397a49c217d296d4d81
https://pubmed.ncbi.nlm.nih.gov/8303306

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Pharmacokinetics and pharmacodynamics of a parenteral testosterone microsphere formulation in the male rat. Demonstration of dose dependence and controlled release

Autor: N R, Peacock, R S, Swerdloff, N, Berman, R M, Gilley, T R, Tice, S, Bhasin

Publikováno v: Journal of andrology. 14(1)

This study examined the pharmacokinetics (the time course and pattern of testosterone release) and pharmacodynamics (effects on accessory sex organ weights, and serum LH and FSH levels) of a biodegradable testosterone microsphere formulation in the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8699dea060db0cd10c082d20f8381be4
https://pubmed.ncbi.nlm.nih.gov/8473236

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Release of human serum albumin from poly(lactide-co-glycolide) microspheres

Autor: M S, Hora, R K, Rana, J H, Nunberg, T R, Tice, R M, Gilley, M E, Hudson

Publikováno v: Pharmaceutical research. 7(11)

Human serum albumin (HSA) was encapsulated in a 50:50 copolymer of DL-lactide/glycolide in the form of microspheres. These microspheres were used as a model formulation to study the feasibility of controlling the release of large proteins over a 20-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b0852accd37c18f3414f40d42f788a7
https://pubmed.ncbi.nlm.nih.gov/2293220

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Vaccine-containing biodegradable microspheres specifically enter the gut-associated lymphoid tissue following oral administration and induce a disseminated mucosal immune response

Autor: J H, Eldridge, J A, Meulbroek, J K, Staas, T R, Tice, R M, Gilley

Publikováno v: Advances in experimental medicine and biology. 251

Biodegradable and biocompatible microspheres have been investigated for their usefulness as a vaccine delivery system for both parenteral and enteral immunization. Microspheres composed of poly(DL-lactide-co-glycolide) which contained a toxoid vaccin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f1b58e12a06234974a8a916fef37bf5
https://pubmed.ncbi.nlm.nih.gov/2610110

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Reversible inhibition of testicular androgen secretion by 3-, 5- and 6-month controlled-release microsphere formulations of the LH-RH agonist [D-Trp6, des-Gly-NH10(2)] LH-RH ethylamide in the dog

Autor: D, Lacoste, F, Labrie, D, Dubé, A, Bélanger, T, Tice, R M, Gilley, K L, Pledger

Publikováno v: Journal of steroid biochemistry. 33(5)

This study examines the effect of treatment with controlled-release poly(DL-lactide-coglycolide) microsphere formulations of the LH-RH agonist [D-Trp6, des-Gly-NH10(2)]-LH-RH ethylamide (LH-RH-A) designed to release about 100 or 200 micrograms of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49fed51134b35400cae8696604888aef
https://pubmed.ncbi.nlm.nih.gov/2689791

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