Zobrazeno 1 - 10
of 15
pro vyhledávání: '"R M Ferris"'
Publikováno v:
Early Phase Drug Evaluation in Man ISBN: 9781349107070
The pharmacological studies that must be conducted on a new chemical entity (NCE) to support the application for an CTX/IND or an MAA/NDA are not defined precisely by the regulatory authorities. Although most readers are probably familiar with the ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a478efda3106a864c079b439937fe
https://doi.org/10.1201/9780367812454-3
https://doi.org/10.1201/9780367812454-3
Autor:
J A, Ascher, J O, Cole, J N, Colin, J P, Feighner, R M, Ferris, H C, Fibiger, R N, Golden, P, Martin, W Z, Potter, E, Richelson
Publikováno v:
The Journal of clinical psychiatry. 56(9)
The mechanism of action of the novel antidepressant bupropion remains unclear after many years of study. A review of the relevant biochemical, in vivo brain microdialysis, electrophysiologic, behavioral, and clinical data clarifies what is known abou
Publikováno v:
Lipids. 7:20-25
The isolated perfused rat liver technique was utilized to study the effect of biliary obstruction on the rates of uptake, synthesis and secretion of14C-labeled cholesterol in an effort to elucidate the mechanism of hypercholesterolemia in this condit
Publikováno v:
Advances in biochemical psychopharmacology. 31
In the present study, bupropion has been shown to be effective in several behavioral models predictive of antidepressant activity suggesting that it should be an effective antidepressant in man. Furthermore, the data also show that the antidepressant
Publikováno v:
Molecular pharmacology. 17(3)
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 209(3)
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 191(3)
Autor:
O J Beaman, R M Ferris
Publikováno v:
Neuropharmacology. 22(11)
The present experiments were undertaken to determine: (1) whether bupropion had any direct effects on receptors present in rat brain; (2) whether the drug could down-regulate postsynaptic beta-adrenergic, alpha 2-adrenergic, serotonergic, imipramine
Publikováno v:
The Journal of clinical psychiatry. 44(5 Pt 2)
The data obtained in these studies show that the antidepressant activity of bupropion cannot be explained by its ability to inhibit MAO present in brain or to increase the release of biogenic amines from nerve endings, since the drug possesses neithe
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 241(1)
The pharmacology of the enantiomers of threo-methylphenidate (MPH) was evaluated in the rat to assess the relative contribution of each isomer to central and peripheral actions of the racemic drug. Fractional recrystallization of binaphthyl phosphate