Zobrazeno 1 - 10
of 15
pro vyhledávání: '"R M Ferris"'
Publikováno v:
Early Phase Drug Evaluation in Man ISBN: 9781349107070
The pharmacological studies that must be conducted on a new chemical entity (NCE) to support the application for an CTX/IND or an MAA/NDA are not defined precisely by the regulatory authorities. Although most readers are probably familiar with the ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a478efda3106a864c079b439937fe
https://doi.org/10.1201/9780367812454-3
https://doi.org/10.1201/9780367812454-3
Autor:
J A, Ascher, J O, Cole, J N, Colin, J P, Feighner, R M, Ferris, H C, Fibiger, R N, Golden, P, Martin, W Z, Potter, E, Richelson
Publikováno v:
The Journal of clinical psychiatry. 56(9)
The mechanism of action of the novel antidepressant bupropion remains unclear after many years of study. A review of the relevant biochemical, in vivo brain microdialysis, electrophysiologic, behavioral, and clinical data clarifies what is known abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3610c29d3ffa1586c0733fb4dd8626df
https://pubmed.ncbi.nlm.nih.gov/7665537
https://pubmed.ncbi.nlm.nih.gov/7665537
Publikováno v:
Lipids. 7:20-25
The isolated perfused rat liver technique was utilized to study the effect of biliary obstruction on the rates of uptake, synthesis and secretion of14C-labeled cholesterol in an effort to elucidate the mechanism of hypercholesterolemia in this condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8383fd6705ecfb5af2dad766f3da671
https://doi.org/10.1007/bf02531264
https://doi.org/10.1007/bf02531264
Publikováno v:
The Journal of clinical psychiatry. 44(5 Pt 2)
The data obtained in these studies show that the antidepressant activity of bupropion cannot be explained by its ability to inhibit MAO present in brain or to increase the release of biogenic amines from nerve endings, since the drug possesses neithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2c8657978c108eaa0e2f9377a84ed1e
https://pubmed.ncbi.nlm.nih.gov/6406468
https://pubmed.ncbi.nlm.nih.gov/6406468
Publikováno v:
Advances in biochemical psychopharmacology. 31
In the present study, bupropion has been shown to be effective in several behavioral models predictive of antidepressant activity suggesting that it should be an effective antidepressant in man. Furthermore, the data also show that the antidepressant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed5195cf57871e4834ab624711e6c62c
https://pubmed.ncbi.nlm.nih.gov/6282058
https://pubmed.ncbi.nlm.nih.gov/6282058
Publikováno v:
Molecular pharmacology. 17(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a93da3e5b71a6c70014814ef6fae9817
https://pubmed.ncbi.nlm.nih.gov/7393212
https://pubmed.ncbi.nlm.nih.gov/7393212
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 209(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5c689fcbac6317231220fb05975ddb4
https://pubmed.ncbi.nlm.nih.gov/220408
https://pubmed.ncbi.nlm.nih.gov/220408
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 191(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63e4c44e0d5992fbd7d54151abb01bd0
https://pubmed.ncbi.nlm.nih.gov/4427288
https://pubmed.ncbi.nlm.nih.gov/4427288
Autor:
O J Beaman, R M Ferris
Publikováno v:
Neuropharmacology. 22(11)
The present experiments were undertaken to determine: (1) whether bupropion had any direct effects on receptors present in rat brain; (2) whether the drug could down-regulate postsynaptic beta-adrenergic, alpha 2-adrenergic, serotonergic, imipramine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95e777aa642fb8e5a2d897296b61253
https://pubmed.ncbi.nlm.nih.gov/6320035
https://pubmed.ncbi.nlm.nih.gov/6320035
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 241(1)
The pharmacology of the enantiomers of threo-methylphenidate (MPH) was evaluated in the rat to assess the relative contribution of each isomer to central and peripheral actions of the racemic drug. Fractional recrystallization of binaphthyl phosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca9f502e02dc3fdb7edfb50797fa4e87
https://pubmed.ncbi.nlm.nih.gov/3572779
https://pubmed.ncbi.nlm.nih.gov/3572779