Zobrazeno 1 - 10
of 18
pro vyhledávání: '"R M Buller"'
Autor:
Lewis C. Cantley, Lynda A. Morrison, T Sarma, David A. Fruman, B Hemmings, R M Buller, C Prejean, Oscar R. Colamonici, O Kurnasov, Anna Usacheva
Publikováno v:
The Journal of Immunology. 167:4553-4559
The Janus kinase/STAT pathway has emerged as the paradigm of IFN-induced protection from viral infections. However, the possible participation of other signaling proteins in this protection is not clearly understood. In this report, we demonstrate th
Autor:
R M, Buller, G J, Palumbo
Publikováno v:
Microbiological Reviews. 55:80-122
Poxviruses are a highly successful family of pathogens, with variola virus, the causative agent of smallpox, being the most notable member. Poxviruses are unique among animal viruses in several respects. First, owing to the cytoplasmic site of virus
Autor:
Nanhai Chen, M K Spriggs, Lydia G. Thebeau, R M Buller, David J. Esteban, Lynda A. Morrison, T VandenBos, T L Born, John E. Sims
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 164(6)
IL-18 induces IFN-γ and NK cell cytotoxicity, making it a logical target for viral antagonism of host defense. We demonstrate that the ectromelia poxvirus p13 protein, bearing homology to the mammalian IL-18 binding protein, binds IL-18, and inhibit
Autor:
E J, Dick, C L, Kittell, H, Meyer, P L, Farrar, S L, Ropp, J J, Esposito, R M, Buller, H, Neubauer, Y H, Kang, A E, McKee
Publikováno v:
Laboratory animal science. 46(6)
Mousepox was diagnosed in and eradicated from a laboratory mouse colony at the Naval Medical Research Institute. The outbreak began with increased mortality in a single room; subsequently, small numbers of animals in separate cages in other rooms wer
Autor:
G R, Peplinski, A K, Tsung, M J, Casey, J B, Meko, T N, Fredrickson, R M, Buller, J A, Norton
Publikováno v:
The cancer journal from Scientific American. 2(1)
This study investigates the feasibility of systemic gene delivery in a tumor-bearing host using a vaccinia virus-based in vivo gene delivery and expression system.A recombinant vaccinia virus encoding human interleukin-1beta (hIL-1beta) was construct
Publikováno v:
The Journal of biological chemistry. 267(35)
Recent studies indicate that viruses may influence polyphosphoinositide levels. This study has examined the effects of vaccinia virus infection on phospholipase C activity. Infection of BS-C-1 cells, an African Green Monkey kidney cell line, or A431
Publikováno v:
Journal of Virology. 61:383-387
Strain C57BL/6 (B6) mice infected with LP-BM5 murine leukemia virus (MuLV) develop a disease which combines abnormal lymphoproliferation with profound immunosuppression and has many features in common with human acquired immunodeficiency syndrome ind
Publikováno v:
Journal of Clinical Microbiology. 18:1220-1225
Ectromelia virus, an orthopoxvirus that can cause extensive morbidity and mortality (mousepox) in colonized mice, has been epizootically responsible for serious disruption of biomedical research since 1930. The lack of a sensitive and specific serolo
Publikováno v:
Nature. 328:77-79
Cytotoxic T lymphocytes (CTL) seem to provide the major line of defence against many viruses. CTL effector functions are mediated primarily by cells carrying the CD8 (Ly-2) antigen (CD8+ cells) and are triggered by interactions of the T-cell receptor
Role of lymphokine-secreting CD8+ T cells in cytotoxic T lymphocyte responses against vaccinia virus
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 142(1)
The present study has examined the relative role of CD4+ and CD8+ Th cells in the generation and reactivation of antivaccinia virus memory CTL responses. We show that mice primed in vivo to vaccinia virus generate in vitro antivaccinia virus memory C