Výsledky vyhledávání

ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia

Autor: R. M. Baldwin, Federico Innocenti, Jacqueline Ramírez, Megan Li, Deanna L. Kroetz, Mark J. Ratain, Eric L. Seiser

Publikováno v: The Pharmacogenomics Journal. 18:35-42

Neutropenia is a common dose-limiting toxicity associated with irinotecan treatment. Although UGT1A1 variants have been associated with neutropenia, a fraction of neutropenia risk remains unaccounted for. To identify additional genetic markers contri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ce93fcbf379b956ca159ed701ae137
https://doi.org/10.1038/tpj.2016.75

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Synthesis and in vivo Evaluation of Fluorine-18 and Iodine-123 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as PET and SPECT Radiotracers for Mapping A2AReceptors

Autor: H. Sharon Lee, R. M. Baldwin, David Alagille, Caroline Papin, Christine Vala, Vincent M. Carroll, Adriana Tavares, Thomas J. Morley, Xuechun Zhang, Gilles Tamagnan, Cristian Constantinescu, Olivier Barret

Publikováno v: ChemMedChem. 11:1936-1943

Imaging agents that target adenosine type 2A (A2A ) receptors play an important role in evaluating new pharmaceuticals targeting these receptors, such as those currently being developed for the treatment of movement disorders like Parkinson's disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e73d8c59c92dc61a3450dce95116123
https://doi.org/10.1002/cmdc.201600219

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Convenient synthesis of18F-radiolabeled R-(−)-N-n-propyl-2-(3-fluoropropanoxy-11-hydroxynoraporphine

Autor: David Alagille, Gilles Tamagnan, Shaohui Zhang, John L. Neumeyer, R. M. Baldwin, Thomas J. Morley, Vamsidhar Akurathi, Wei Li, Anna W. Sromek, Alan B. Packard

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 57:725-729

Aporphines are attractive candidates for imaging D2 receptor function because, as agonists rather than antagonists, they are selective for the receptor in the high affinity state. In contrast, D2 antagonists do not distinguish between the high and lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2536422dcef868d9cf3930f360342093
https://doi.org/10.1002/jlcr.3246

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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance)

Autor: Joel Mefford, John S. Witte, Robert M. Plenge, Megan Li, Aparna Chhibber, Eric P. Winer, Michiaki Kubo, R. M. Baldwin, Deanna L. Kroetz, Marylyn D. Ritchie, Sarah A. Pendergrass, Kouros Owzar, Clifford A. Hudis, Mark J. Ratain, Howard L. McLeod, Lawrence N. Shulman, Yusuke Nakamura, Eli A. Stahl, Hitoshi Zembutsu

Publikováno v: The pharmacogenomics journal

Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals, there are no known risk factors that predispose patients to the adverse event, and pathogenesis for paclitaxel-induced peripheral neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b2cbe2a7d9fba4eae53b4938b750a0
https://doi.org/10.1038/tpj.2014.2

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Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression

Autor: M Habashian, Jason M. Gow, Mary V. Relling, Deanna L. Kroetz, Mark J. Ratain, Wanqing Liu, R. M. Baldwin, Svetlana Markova, Tan D. Nguyen

Publikováno v: The pharmacogenomics journal

Multidrug resistance protein 2 (MRP2, ABCC2) is an efflux membrane transporter highly expressed in liver, kidney and intestine with important physiological and pharmacological roles. The goal of this study was to investigate the functional significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c895673cc72e736c5209e85850e33337
https://doi.org/10.1038/tpj.2012.20

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Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Cι-mediated attenuation of p38 MAP kinase signaling

Autor: M A Andrade, M Garratt-Lalonde, P M Krzyzanowski, Doris A. E. Parolin, Ian A. J. Lorimer, R M Baldwin

Publikováno v: Oncogene. 25:2909-2919

Glioblastoma multiforme is an aggressive form of brain cancer that responds poorly to chemotherapy and is generally incurable. The basis for the poor response of this cancer to chemotherapy is not well understood. The atypical protein kinases C (PKCi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f2678fbd41ff05681bcaea7e7ade48
https://doi.org/10.1038/sj.onc.1209312

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Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects

Autor: John Seibyl, C H van Dyck, John H. Krystal, R. M. Baldwin, Marc Laruelle, Roberto Gil, Robert B. Innis, Cyril D'Souza, Anissa Abi-Dargham, W Rosenblatt, Elinore McCance, Dennis S. Charney, Christine L Fingado, Joseph Erdos, Sami S. Zoghbi

Publikováno v: Proceedings of the National Academy of Sciences. 93:9235-9240

The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic transmission is associated with this illness, but direct observation of abnormalities of dopamine function in schizophrenia has remained elusive. We used a newly dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc496e579e23144844587475c15be53
https://doi.org/10.1073/pnas.93.17.9235

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Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2.beta.-carbomethoxy-3.beta.-(4-iodophenyl)tropane (.beta.-CIT) to monoamine transporters

Autor: S. Wang, John L. Neumeyer, B E Scanley, Yigong Gao, R. M. Baldwin, Robert B. Innis, Marc Laruelle

Publikováno v: Journal of Medicinal Chemistry. 36:1914-1917

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3426dc9c6d9e0b9849d339495b915673
https://doi.org/10.1021/jm00065a014

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Preparation of [123I]- and [125I]epidepride: A dopamine D-2 receptor antagonist radioligand

Autor: T. De Paulis, Robert M. Kessler, Dennis E. Schmidt, Jeffery A. Clanton, R. M. Baldwin, Mohammed Ansari, Ronald G. Manning

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 29:745-751

(S)-(−)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[123I]iodo-2,3-dimethoxybenzamide (TDP 517) (proposed generic name, [123I]epidepride) is the iodine-123 substituted analogue of isoremoxipride (FLB 457), both of which are very potent dopamine D-2 antago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2d7079bd08fc715833feb1cd41a9a34
https://doi.org/10.1002/jlcr.2580290703

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Regulation of glioblastoma cell invasion by PKC iota and RhoB

Autor: Doris A. E. Parolin, Ian A. J. Lorimer, R M Baldwin

Publikováno v: Oncogene. 27(25)

Glioblastoma multiforme is the most aggressive form of primary brain tumor and remains largely incurable, in large part, due to its highly invasive nature. The phosphoinositide (PI) 3-kinase pathway is often constitutively active in these tumors due

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec251970261e458cc7ff6297a128ef71
https://pubmed.ncbi.nlm.nih.gov/18212741

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