Výsledky vyhledávání - "R M, de Wildt"

Somatic insertions and deletions shape the human antibody repertoire

Autor: R M, de Wildt, W J, van Venrooij, G, Winter, R M, Hoet, I M, Tomlinson

Publikováno v: Journal of molecular biology. 294(3)

We have sequenced the heavy and light chain genes from 365 IgG(+) B cells and found that 24 (6.5 %) contain somatically introduced insertions or deletions. These insertions and deletions are clustered at "hot-spots" in the antigen-binding site and fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fa9bc5c754ea7c223785eb1c5cc95d2
https://pubmed.ncbi.nlm.nih.gov/10610790

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Comparable heavy and light chain pairings in normal and systemic lupus erythematosus IgG(+) B cells

Autor: R M, de Wildt, I M, Tomlinson, W J, van Venrooij, G, Winter, R M, Hoet

Publikováno v: European journal of immunology. 30(1)

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the presence of high immunoglobulin serum titers, but the mechanism by which these arise remains unclear. It has been suggested that the disease is associated with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be9c91eb11caf76497170281ea693284
https://pubmed.ncbi.nlm.nih.gov/10602048

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