Zobrazeno 1 - 10 of 31 pro vyhledávání: '"R M, Woodward"'
1
Gut peptide regulation of food intake - evidence for the modulation of hedonic feeding
Autor: Frank Reimann, Fiona M. Gribble, Jo E. Lewis, Orla R. M. Woodward
Publikováno v: The Journal of physiologyReferences. 600(5)
The number of people living with obesity has tripled worldwide since 1975 with serious implications for public health, as obesity is linked to a significantly higher chance of early death from associated comorbidities (metabolic syndrome, type 2 diab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b318c584e2afceaf03731f5241b887e4
https://pubmed.ncbi.nlm.nih.gov/34152020
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2
Selective stimulation of colonic L cells improves metabolic outcomes in mice
Autor: Orla R. M. Woodward, Rachel E. Foreman, Frank Reimann, Jo E. Lewis, Deborah A. Goldspink, Fiona M. Gribble, Richard G. Kay, Emily L. Miedzybrodzka
Publikováno v: Diabetologia
Aims/hypothesis Insulin-like peptide-5 (INSL5) is found only in distal colonic L cells, which co-express glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). GLP-1 is a well-known insulin secretagogue, and GLP-1 and PYY are anorexigenic, whereas INS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9e44de7d35c9b625a89a0afe16545c
https://www.repository.cam.ac.uk/handle/1810/303048
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3
P5-17-07: HER2+ Metastatic Breast Cancer Patient Experiences on Treatment in the Biologic Era: Findings from a Community Web-Based Survey
Autor: Melissa Brammer, Joseph Menzin, Deepa Lalla, Musa Mayer, K Lang, JF Doan, Sara A. Hurvitz, R. M. Woodward, Debu Tripathy
Publikováno v: Cancer Research. 71:P5-17
Background: HER2−directed biologic therapy is part of recommended treatment for women with HER2+ metastatic breast cancer (MBC). However, little is known regarding the quality of life (QoL) experience and symptom burden in these women outside of cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ad86066e563ba1340c54d0a904c4dfb
https://doi.org/10.1158/0008-5472.sabcs11-p5-17-07
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4
Synthesis and in Vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor
Autor: Michael B. Bolger, Catherine L. Kimbrough, S. Hasan Tahir, R. M. Woodward, Edward R. Whittemore, Ravi Upasani, Derk J. Hogenkamp, Manuel Acosta-Burruel, Mian Alauddin, Nancy C. Lan, Kelvin W. Gee, Jon E. Hawkinson
Publikováno v: Journal of Medicinal Chemistry. 40:61-72
Two naturally occurring metabolites of progesterone, 3 alpha-hydroxy-5 alpha- and 5 beta-pregnan-20-one (1 and 2), are potent allosteric modulators of the GABAA receptor. Their therapeutic potential as anxiolytics, anticonvulsants, and sedative/hypno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6841119f97b78b98679f20860850959a
https://doi.org/10.1021/jm960021x
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5
Terahertz pulsed imaging of skin cancer in the time and frequency domain
Autor: R M, Woodward, V P, Wallace, D D, Arnone, E H, Linfield, M, Pepper
Publikováno v: Journal of biological physics. 29(2-3)
Terahertz Pulsed Imaging(TPI) is a new medical imaging modality forthe detection of epithelial cancers. Overthe last two years this technique has beenapplied to the study of in vitrobasal cell carcinoma (BCC). Usingtime-domain analysis the contrast b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e61dc881342b8afb6faac58e78875fb
https://pubmed.ncbi.nlm.nih.gov/23345842
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7
Expression of mammalian gamma-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes
Autor: Ricardo Miledi, L Polenzani, R. M. Woodward
Publikováno v: Proceedings of the National Academy of Sciences. 88:4318-4322
Gamma-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in mammalian brain, is known to interact with two classes of GABA receptors denoted GABAA and GABAB. Using Xenopus oocytes, we compared the electrical and pharmacological propertie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad90551931a70c987bbed0a141f578c
https://doi.org/10.1073/pnas.88.10.4318
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9
Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys
Autor: P J, Blanchet, S, Konitsiotis, E R, Whittemore, Z L, Zhou, R M, Woodward, T N, Chase
Publikováno v: The Journal of pharmacology and experimental therapeutics. 290(3)
The antiparkinsonian and antidyskinetic profile of two N-methyl-D-aspartate (NMDA) receptor antagonists, a competitive antagonist, (R)-4-oxo-5-phosphononorvaline (MDL 100,453), and a novel noncompetitive allosteric site antagonist, 4-hydroxy-N-[2-(4-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c3b3e134e09e25c154210d9b4dff932
https://pubmed.ncbi.nlm.nih.gov/10454475
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10
Structure-activity relationship for a series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles: potent subtype-selective inhibitors of N-methyl-D-aspartate (NMDA) receptors
Autor: A P, Tamiz, E R, Whittemore, R M, Woodward, R B, Upasani, J F, Keana
Publikováno v: Bioorganicmedicinal chemistry letters. 9(11)
A series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles was synthesized as potential antagonists for the NR1A/2B subtype of N-methyl-D-aspartate (NMDA) receptors. Assayed by electrical recording under steady-state conditions, 7-hydroxy-2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3aa0ae826bc92da45915457b66c9d37c
https://pubmed.ncbi.nlm.nih.gov/10386947
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