Výsledky vyhledávání - "R M, Van Den Wijngaard"

Reversal of visceral hypersensitivity in rat by Menthacarin

Autor: S, Botschuijver, O, Welting, E, Levin, D, Maria-Ferreira, E, Koch, R C, Montijn, J, Seppen, T B M, Hakvoort, F H J, Schuren, W J, de Jonge, R M, van den Wijngaard

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 30(6)

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder associated with altered gastrointestinal microflora and increased nociception to colonic distension. This visceral hypersensitivity can be reversed in our rat maternal separation mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be46f792057695a9046e481e59047117
https://pubmed.ncbi.nlm.nih.gov/29383802

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Altered brain activation to colorectal distention in visceral hypersensitive maternal-separated rats

Autor: M M, Wouters, S, Van Wanrooy, C, Casteels, A, Nemethova, A, de Vries, L, Van Oudenhove, R M, Van den Wijngaard, K, Van Laere, G, Boeckxstaens

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 24(7)

Early life trauma can predispose to increased visceral pain perception. Human neuroimaging studies emphasize that altered brain processing may contribute to increased visceral sensitivity. The aim of our study was to evaluate brain responses to painf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42f808faa1a6e1529848d96e88c645a1
https://pubmed.ncbi.nlm.nih.gov/22709237

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Peripheral α-helical CRF (9-41) does not reverse stress-induced mast cell dependent visceral hypersensitivity in maternally separated rats

Autor: R M, van den Wijngaard, O I, Stanisor, S A, van Diest, O, Welting, M M, Wouters, W J, de Jonge, G E, Boeckxstaens

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 24(3)

Acute stress-induced hypersensitivity to colorectal distention was shown to depend on corticotropin releasing factor (CRF)-induced mast cell degranulation. At present it remains unclear whether CRF also induces chronic poststress activation of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::247c228905a1f65d634681b7dc4e43b4
https://pubmed.ncbi.nlm.nih.gov/22316289

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Mast cells trigger epithelial barrier dysfunction, bacterial translocation and postoperative ileus in a mouse model

Autor: S A, Snoek, S, Dhawan, S H, van Bree, C, Cailotto, S A, van Diest, J M, Duarte, O I, Stanisor, F W, Hilbers, L, Nijhuis, A, Koeman, R M, van den Wijngaard, C J, Zuurbier, G E, Boeckxstaens, W J, de Jonge

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 24(2)

Abdominal surgery involving bowel manipulation commonly results in inflammation of the bowel wall, which leads to impaired intestinal motility and postoperative ileus (POI). Mast cells have shown to play a key role in the pathogenesis of POI in mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d68f1e5ab83047956db356cc8e00161
https://pubmed.ncbi.nlm.nih.gov/22122661

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Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study

Autor: B, Braak, T K, Klooker, M M, Wouters, A, Lei, R M, van den Wijngaard, G E, Boeckxstaens

Publikováno v: Alimentary pharmacologytherapeutics. 34(6)

Functional dyspepsia is one of the most prevalent (15-40%) functional gastrointestinal disorders. Antidepressants such as amitriptyline are often used in these patients, but clinical studies are currently lacking.To evaluate the effect of 8 weeks of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::933d417347bfcab81dba2c7c49f093a2
https://pubmed.ncbi.nlm.nih.gov/21767283

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The cannabinoid receptor agonist delta-9-tetrahydrocannabinol does not affect visceral sensitivity to rectal distension in healthy volunteers and IBS patients

Autor: T K, Klooker, K E M, Leliefeld, R M, Van Den Wijngaard, G E E, Boeckxstaens

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 23(1)

Visceral hypersensitivity to distension is thought to play an important role in the pathophysiology of the irritable bowel syndrome (IBS). Cannabinoids are known to decrease somatic pain perception, but their effect on visceral sensitivity in IBS rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be68b4090102ef571fb37d3b2de70127
https://pubmed.ncbi.nlm.nih.gov/20718944

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Intestinal handling-induced mast cell activation and inflammation in human postoperative ileus

Autor: F O The, R J Bennink, W M Ankum, M R Buist, O R C Busch, D J Gouma, S van der Heide, R M van den Wijngaard, W J de Jonge, G E Boeckxstaens

Publikováno v: Gut, 57(1), 33-40. BMJ Publishing Group
Gut, 57(1), 33-40. BMJ PUBLISHING GROUP

Background: Murine postoperative ileus results from intestinal inflammation triggered by manipulation-induced mast cell activation. As its extent depends on the degree of handling and subsequent inflammation, it is hypothesised that the faster recove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7269d659103f026c2dda9313d26df7
https://pure.amc.nl/en/publications/intestinal-handlinginduced-mast-cell-activation-and-inflammation-in-human-postoperative-ileus(ee6ab12a-d654-439d-b9b3-7a7e6d49ac5b).html

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Expression and modulation of apoptosis regulatory molecules in human melanocytes: significance in vitiligo

Autor: R M, van den Wijngaard, J, Aten, A, Scheepmaker, I C, Le Poole, A J, Tigges, W, Westerhof, P K, Das

Publikováno v: The British journal of dermatology. 143(3)

Although the aetiology of the hypopigmentary disorder vitiligo is ill understood, it is clear that pigment producing cells are absent from vitiliginous lesional skin. The present study was designed to investigate the possible role of melanocyte-expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ce24581df23c2779547f549aefc6aa6
https://pubmed.ncbi.nlm.nih.gov/10971331

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A novel, antigen-presenting function of melanocytes and its possible relationship to hypopigmentary disorders

Autor: I C, Le Poole, T, Mutis, R M, van den Wijngaard, W, Westerhof, T, Ottenhoff, R R, de Vries, P K, Das

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 151(12)

It is now well established that cultured human melanocytes are capable of expressing immunologically important cell surface molecules and that they can produce cytokines. Not all cells with the ability to express MHC class II molecules are capable of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b1b83f5c710446822632b227e392a98
https://pubmed.ncbi.nlm.nih.gov/8258725

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